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Passive infusion of an S2-Stem broadly neutralizing antibody protects against SARS-CoV-2 infection and lower airway inflammation in rhesus macaques.

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Title: Passive infusion of an S2-Stem broadly neutralizing antibody protects against SARS-CoV-2 infection and lower airway inflammation in rhesus macaques.
Authors: Edwards CT; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Karunakaran KA; Department of Pathology, Microbiology & Immunology, Vanderbilt University, Nashville, TN 37235, USA., Garcia E; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Mayo Clinic Medical Scientist Training Program, Mayo Clinic College of Medicine and Science, 200 First Street SW, Rochester, Minnesota 55356, USA., Beutler N; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA., Gagne M; Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Golden N; Tulane National Primate Research Center, Covington, LA, USA., Aoued H; Emory National Primate Research Center Genomics Core, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Pellegrini KL; Emory National Primate Research Center Genomics Core, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Burnett MR; Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Honeycutt CC; Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Lapp SA; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Ton T; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Lin MC; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Metz A; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Bombin A; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA., Goff K; Tulane National Primate Research Center, Covington, LA, USA., Scheuermann SE; Tulane National Primate Research Center, Covington, LA, USA., Wilkes A; Division of Animal Resources, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Wood JS; Division of Animal Resources, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Ehnert S; Division of Animal Resources, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Weissman S; Division of Animal Resources, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Curran EH; Division of Pathology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Roy M; Division of Pathology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Dessasau E; Division of Histology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Paiardini M; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Emory Vaccine Center, Emory National Primate Research Center, Atlanta, Georgia, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA., Upadhyay AA; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Moore I; Division of Pathology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA., Maness NJ; Tulane National Primate Research Center, Covington, LA, USA., Douek DC; Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Piantadosi A; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.; Emory Vaccine Center, Emory National Primate Research Center, Atlanta, Georgia, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA., Andrabi R; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA., Rogers TR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Division of Infectious Diseases, Department of Medicine, University of California, San Diego, La Jolla, CA 92037, USA., Burton DR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA., Bosinger SE; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Emory Vaccine Center, Emory National Primate Research Center, Atlanta, Georgia, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jul 30. Date of Electronic Publication: 2024 Jul 30.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Label: Title
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  Data: Passive infusion of an S2-Stem broadly neutralizing antibody protects against SARS-CoV-2 infection and lower airway inflammation in rhesus macaques.
– Name: Author
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  Data: <searchLink fieldCode="AU" term="%22Edwards+CT%22">Edwards CT</searchLink>; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.<br /><searchLink fieldCode="AU" term="%22Karunakaran+KA%22">Karunakaran KA</searchLink>; Department of Pathology, Microbiology & Immunology, Vanderbilt University, Nashville, TN 37235, USA.<br /><searchLink fieldCode="AU" term="%22Garcia+E%22">Garcia E</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Mayo Clinic Medical Scientist Training Program, Mayo Clinic College of Medicine and Science, 200 First Street SW, Rochester, Minnesota 55356, USA.<br /><searchLink fieldCode="AU" term="%22Beutler+N%22">Beutler N</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Gagne+M%22">Gagne M</searchLink>; Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Golden+N%22">Golden N</searchLink>; Tulane National Primate Research Center, Covington, LA, USA.<br /><searchLink fieldCode="AU" term="%22Aoued+H%22">Aoued H</searchLink>; Emory National Primate Research Center Genomics Core, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.<br /><searchLink fieldCode="AU" term="%22Pellegrini+KL%22">Pellegrini KL</searchLink>; Emory National Primate Research Center Genomics Core, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.<br /><searchLink fieldCode="AU" term="%22Burnett+MR%22">Burnett MR</searchLink>; Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Honeycutt+CC%22">Honeycutt CC</searchLink>; Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Lapp+SA%22">Lapp SA</searchLink>; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.<br /><searchLink fieldCode="AU" term="%22Ton+T%22">Ton T</searchLink>; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.<br /><searchLink fieldCode="AU" term="%22Lin+MC%22">Lin MC</searchLink>; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.<br /><searchLink fieldCode="AU" term="%22Metz+A%22">Metz A</searchLink>; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.<br /><searchLink fieldCode="AU" term="%22Bombin+A%22">Bombin A</searchLink>; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Goff+K%22">Goff K</searchLink>; Tulane National Primate Research Center, Covington, LA, USA.<br /><searchLink fieldCode="AU" term="%22Scheuermann+SE%22">Scheuermann SE</searchLink>; Tulane National Primate Research Center, Covington, LA, USA.<br /><searchLink fieldCode="AU" term="%22Wilkes+A%22">Wilkes A</searchLink>; Division of Animal Resources, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.<br /><searchLink fieldCode="AU" term="%22Wood+JS%22">Wood JS</searchLink>; Division of Animal Resources, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.<br /><searchLink fieldCode="AU" term="%22Ehnert+S%22">Ehnert S</searchLink>; Division of Animal Resources, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.<br /><searchLink fieldCode="AU" term="%22Weissman+S%22">Weissman S</searchLink>; Division of Animal Resources, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.<br /><searchLink fieldCode="AU" term="%22Curran+EH%22">Curran EH</searchLink>; Division of Pathology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.<br /><searchLink fieldCode="AU" term="%22Roy+M%22">Roy M</searchLink>; Division of Pathology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.<br /><searchLink fieldCode="AU" term="%22Dessasau+E%22">Dessasau E</searchLink>; Division of Histology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.<br /><searchLink fieldCode="AU" term="%22Paiardini+M%22">Paiardini M</searchLink>; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Emory Vaccine Center, Emory National Primate Research Center, Atlanta, Georgia, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Upadhyay+AA%22">Upadhyay AA</searchLink>; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.<br /><searchLink fieldCode="AU" term="%22Moore+I%22">Moore I</searchLink>; Division of Pathology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Maness+NJ%22">Maness NJ</searchLink>; Tulane National Primate Research Center, Covington, LA, USA.<br /><searchLink fieldCode="AU" term="%22Douek+DC%22">Douek DC</searchLink>; Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Piantadosi+A%22">Piantadosi A</searchLink>; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.; Emory Vaccine Center, Emory National Primate Research Center, Atlanta, Georgia, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Andrabi+R%22">Andrabi R</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Rogers+TR%22">Rogers TR</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Division of Infectious Diseases, Department of Medicine, University of California, San Diego, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Burton+DR%22">Burton DR</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Bosinger+SE%22">Bosinger SE</searchLink>; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA.; Emory Vaccine Center, Emory National Primate Research Center, Atlanta, Georgia, USA.; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.
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