A First-in-Class Pyrazole-isoxazole Enhanced Antifungal Activity of Voriconazole: Synergy Studies in an Azole-Resistant Candida albicans Strain, Computational Investigation and in Vivo Validation in a Galleria mellonella Fungal Infection Model.
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| Title: | A First-in-Class Pyrazole-isoxazole Enhanced Antifungal Activity of Voriconazole: Synergy Studies in an Azole-Resistant Candida albicans Strain, Computational Investigation and in Vivo Validation in a Galleria mellonella Fungal Infection Model. |
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| Authors: | Pelliccia S; Department of Pharmacy (DoE 2023-2027), University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy., Russomanno P; Magnetic Resonance Centre (CERM), Consorzio Interuniversitario Risonanze Magnetiche di Metallo Proteine (CIRMMP) and Department of Chemistry 'Ugo Schiff', University of Florence, Via L. Sacconi 6, Sesto Fiorentino 50019, Italy., Barone S; Department of Pharmacy (DoE 2023-2027), University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy., Mateu B; Department of Pharmacy (DoE 2023-2027), University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy., Alfano AI; Department of Pharmacy (DoE 2023-2027), University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy., Miranda M; Department of Pharmaceutical and Cell Biological Chemistry, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany., Coretti L; Department of Pharmacy (DoE 2023-2027), University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy., Lembo F; Department of Pharmacy (DoE 2023-2027), University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy., Piccolo M; BioChemLab, Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy., Irace C; BioChemLab, Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy., Friggeri L; Department of Cell and Development Biology, U4225 Medical Research Building III, 465 21st Avenue South Room 4160 MRB III Nashville, Tennessee 37232, United States., Hargrove TY; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States., Curtis A; Department of Biology, Maynooth University, W23 F2H6 Maynooth, Co. Kildare, Ireland., Lepesheva GI; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States., Kavanagh K; Department of Biology, Maynooth University, W23 F2H6 Maynooth, Co. Kildare, Ireland., Buommino E; Department of Pharmacy (DoE 2023-2027), University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy., Brindisi M; Department of Pharmacy (DoE 2023-2027), University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy. |
| Source: | Journal of medicinal chemistry [J Med Chem] 2024 Aug 22; Vol. 67 (16), pp. 14256-14276. Date of Electronic Publication: 2024 Aug 08. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 39115219 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A First-in-Class Pyrazole-isoxazole Enhanced Antifungal Activity of Voriconazole: Synergy Studies in an Azole-Resistant Candida albicans Strain, Computational Investigation and in Vivo Validation in a Galleria mellonella Fungal Infection Model. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Pelliccia+S%22">Pelliccia S</searchLink>; Department of Pharmacy (DoE 2023-2027), University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Russomanno+P%22">Russomanno P</searchLink>; Magnetic Resonance Centre (CERM), Consorzio Interuniversitario Risonanze Magnetiche di Metallo Proteine (CIRMMP) and Department of Chemistry 'Ugo Schiff', University of Florence, Via L. Sacconi 6, Sesto Fiorentino 50019, Italy.<br /><searchLink fieldCode="AU" term="%22Barone+S%22">Barone S</searchLink>; Department of Pharmacy (DoE 2023-2027), University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Mateu+B%22">Mateu B</searchLink>; Department of Pharmacy (DoE 2023-2027), University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Alfano+AI%22">Alfano AI</searchLink>; Department of Pharmacy (DoE 2023-2027), University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Miranda+M%22">Miranda M</searchLink>; Department of Pharmaceutical and Cell Biological Chemistry, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Coretti+L%22">Coretti L</searchLink>; Department of Pharmacy (DoE 2023-2027), University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Lembo+F%22">Lembo F</searchLink>; Department of Pharmacy (DoE 2023-2027), University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Piccolo+M%22">Piccolo M</searchLink>; BioChemLab, Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Irace+C%22">Irace C</searchLink>; BioChemLab, Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Friggeri+L%22">Friggeri L</searchLink>; Department of Cell and Development Biology, U4225 Medical Research Building III, 465 21st Avenue South Room 4160 MRB III Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22Hargrove+TY%22">Hargrove TY</searchLink>; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22Curtis+A%22">Curtis A</searchLink>; Department of Biology, Maynooth University, W23 F2H6 Maynooth, Co. Kildare, Ireland.<br /><searchLink fieldCode="AU" term="%22Lepesheva+GI%22">Lepesheva GI</searchLink>; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.<br /><searchLink fieldCode="AU" term="%22Kavanagh+K%22">Kavanagh K</searchLink>; Department of Biology, Maynooth University, W23 F2H6 Maynooth, Co. Kildare, Ireland.<br /><searchLink fieldCode="AU" term="%22Buommino+E%22">Buommino E</searchLink>; Department of Pharmacy (DoE 2023-2027), University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Brindisi+M%22">Brindisi M</searchLink>; Department of Pharmacy (DoE 2023-2027), University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2024 Aug 22; Vol. 67 (16), pp. 14256-14276. <i>Date of Electronic Publication: </i>2024 Aug 08. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=39115219 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1021/acs.jmedchem.4c01109 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 14256 Titles: – TitleFull: A First-in-Class Pyrazole-isoxazole Enhanced Antifungal Activity of Voriconazole: Synergy Studies in an Azole-Resistant Candida albicans Strain, Computational Investigation and in Vivo Validation in a Galleria mellonella Fungal Infection Model. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Pelliccia S – PersonEntity: Name: NameFull: Russomanno P – PersonEntity: Name: NameFull: Barone S – PersonEntity: Name: NameFull: Mateu B – PersonEntity: Name: NameFull: Alfano AI – PersonEntity: Name: NameFull: Miranda M – PersonEntity: Name: NameFull: Coretti L – PersonEntity: Name: NameFull: Lembo F – PersonEntity: Name: NameFull: Piccolo M – PersonEntity: Name: NameFull: Irace C – PersonEntity: Name: NameFull: Friggeri L – PersonEntity: Name: NameFull: Hargrove TY – PersonEntity: Name: NameFull: Curtis A – PersonEntity: Name: NameFull: Lepesheva GI – PersonEntity: Name: NameFull: Kavanagh K – PersonEntity: Name: NameFull: Buommino E – PersonEntity: Name: NameFull: Brindisi M IsPartOfRelationships: – BibEntity: Dates: – D: 22 M: 08 Text: 2024 Aug 22 Type: published Y: 2024 Identifiers: – Type: issn-electronic Value: 1520-4804 Numbering: – Type: volume Value: 67 – Type: issue Value: 16 Titles: – TitleFull: Journal of medicinal chemistry Type: main |
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