A First-in-Class Pyrazole-isoxazole Enhanced Antifungal Activity of Voriconazole: Synergy Studies in an Azole-Resistant Candida albicans Strain, Computational Investigation and in Vivo Validation in a Galleria mellonella Fungal Infection Model.
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| Title: | A First-in-Class Pyrazole-isoxazole Enhanced Antifungal Activity of Voriconazole: Synergy Studies in an Azole-Resistant Candida albicans Strain, Computational Investigation and in Vivo Validation in a Galleria mellonella Fungal Infection Model. |
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| Authors: | Pelliccia S; Department of Pharmacy (DoE 2023-2027), University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy., Russomanno P; Magnetic Resonance Centre (CERM), Consorzio Interuniversitario Risonanze Magnetiche di Metallo Proteine (CIRMMP) and Department of Chemistry 'Ugo Schiff', University of Florence, Via L. Sacconi 6, Sesto Fiorentino 50019, Italy., Barone S; Department of Pharmacy (DoE 2023-2027), University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy., Mateu B; Department of Pharmacy (DoE 2023-2027), University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy., Alfano AI; Department of Pharmacy (DoE 2023-2027), University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy., Miranda M; Department of Pharmaceutical and Cell Biological Chemistry, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany., Coretti L; Department of Pharmacy (DoE 2023-2027), University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy., Lembo F; Department of Pharmacy (DoE 2023-2027), University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy., Piccolo M; BioChemLab, Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy., Irace C; BioChemLab, Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy., Friggeri L; Department of Cell and Development Biology, U4225 Medical Research Building III, 465 21st Avenue South Room 4160 MRB III Nashville, Tennessee 37232, United States., Hargrove TY; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States., Curtis A; Department of Biology, Maynooth University, W23 F2H6 Maynooth, Co. Kildare, Ireland., Lepesheva GI; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States., Kavanagh K; Department of Biology, Maynooth University, W23 F2H6 Maynooth, Co. Kildare, Ireland., Buommino E; Department of Pharmacy (DoE 2023-2027), University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy., Brindisi M; Department of Pharmacy (DoE 2023-2027), University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy. |
| Source: | Journal of medicinal chemistry [J Med Chem] 2024 Aug 22; Vol. 67 (16), pp. 14256-14276. Date of Electronic Publication: 2024 Aug 08. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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