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Engineered cytokine/antibody fusion proteins improve IL-2 delivery to pro-inflammatory cells and promote antitumor activity.

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Title: Engineered cytokine/antibody fusion proteins improve IL-2 delivery to pro-inflammatory cells and promote antitumor activity.
Authors: Leonard EK; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Tomala J; Institute of Biotechnology of the Academy of Sciences of the Czech Republic, Vestec, Czech Republic.; Department of Chemical & Biomolecular Engineering and., Gould JR; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Leff MI; Department of Biology, Johns Hopkins University, Baltimore, Maryland, USA., Lin JX; Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health (NIH), Bethesda, Maryland, USA., Li P; Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health (NIH), Bethesda, Maryland, USA., Porter MJ; Department of Chemistry, Johns Hopkins University, Baltimore, Maryland, USA., Johansen ER; Department of Chemistry, Johns Hopkins University, Baltimore, Maryland, USA., Thompson L; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Cao SD; Department of Chemical & Biomolecular Engineering and., Hou S; Department of Plastic & Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Henclova T; Institute of Biotechnology of the Academy of Sciences of the Czech Republic, Vestec, Czech Republic., Huliciak M; Institute of Biotechnology of the Academy of Sciences of the Czech Republic, Vestec, Czech Republic.; Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA., Sargunas PR; Department of Chemical & Biomolecular Engineering and., Fabilane CS; Program in Molecular Biophysics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Vaněk O; Department of Biochemistry, Faculty of Science, Charles University, Prague, Czech Republic., Kovar M; Laboratory of Tumor Immunology, Institute of Microbiology of the Academy of Sciences of the Czech Republic, Prague, Czech Republic., Schneider B; Institute of Biotechnology of the Academy of Sciences of the Czech Republic, Vestec, Czech Republic., Raimondi G; Vascularized Composite Allotransplantation Laboratory, Department of Plastic and Reconstructive Surgery., Leonard WJ; Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health (NIH), Bethesda, Maryland, USA., Spangler JB; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Chemical & Biomolecular Engineering and.; Translational Tissue Engineering Center.; Department of Oncology.; Bloomberg-Kimmel Institute for Cancer Immunotherapy.; Sidney Kimmel Comprehensive Cancer Center; and.; Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Source: JCI insight [JCI Insight] 2024 Sep 24; Vol. 9 (18). Date of Electronic Publication: 2024 Sep 24.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Engineered cytokine/antibody fusion proteins improve IL-2 delivery to pro-inflammatory cells and promote antitumor activity.
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  Data: <searchLink fieldCode="AU" term="%22Leonard+EK%22">Leonard EK</searchLink>; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Tomala+J%22">Tomala J</searchLink>; Institute of Biotechnology of the Academy of Sciences of the Czech Republic, Vestec, Czech Republic.; Department of Chemical & Biomolecular Engineering and.<br /><searchLink fieldCode="AU" term="%22Gould+JR%22">Gould JR</searchLink>; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Leff+MI%22">Leff MI</searchLink>; Department of Biology, Johns Hopkins University, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Lin+JX%22">Lin JX</searchLink>; Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health (NIH), Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Li+P%22">Li P</searchLink>; Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health (NIH), Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Porter+MJ%22">Porter MJ</searchLink>; Department of Chemistry, Johns Hopkins University, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Johansen+ER%22">Johansen ER</searchLink>; Department of Chemistry, Johns Hopkins University, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Thompson+L%22">Thompson L</searchLink>; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Cao+SD%22">Cao SD</searchLink>; Department of Chemical & Biomolecular Engineering and.<br /><searchLink fieldCode="AU" term="%22Hou+S%22">Hou S</searchLink>; Department of Plastic & Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Henclova+T%22">Henclova T</searchLink>; Institute of Biotechnology of the Academy of Sciences of the Czech Republic, Vestec, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Huliciak+M%22">Huliciak M</searchLink>; Institute of Biotechnology of the Academy of Sciences of the Czech Republic, Vestec, Czech Republic.; Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Sargunas+PR%22">Sargunas PR</searchLink>; Department of Chemical & Biomolecular Engineering and.<br /><searchLink fieldCode="AU" term="%22Fabilane+CS%22">Fabilane CS</searchLink>; Program in Molecular Biophysics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Vaněk+O%22">Vaněk O</searchLink>; Department of Biochemistry, Faculty of Science, Charles University, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Kovar+M%22">Kovar M</searchLink>; Laboratory of Tumor Immunology, Institute of Microbiology of the Academy of Sciences of the Czech Republic, Prague, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Schneider+B%22">Schneider B</searchLink>; Institute of Biotechnology of the Academy of Sciences of the Czech Republic, Vestec, Czech Republic.<br /><searchLink fieldCode="AU" term="%22Raimondi+G%22">Raimondi G</searchLink>; Vascularized Composite Allotransplantation Laboratory, Department of Plastic and Reconstructive Surgery.<br /><searchLink fieldCode="AU" term="%22Leonard+WJ%22">Leonard WJ</searchLink>; Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health (NIH), Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Spangler+JB%22">Spangler JB</searchLink>; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Chemical & Biomolecular Engineering and.; Translational Tissue Engineering Center.; Department of Oncology.; Bloomberg-Kimmel Institute for Cancer Immunotherapy.; Sidney Kimmel Comprehensive Cancer Center; and.; Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
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  Data: <searchLink fieldCode="JN" term="%22101676073%22">JCI insight</searchLink> [JCI Insight] 2024 Sep 24; Vol. 9 (18). <i>Date of Electronic Publication: </i>2024 Sep 24.
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