mTOR activation induces endolysosomal remodeling and nonclassical secretion of IL-32 via exosomes in inflammatory reactive astrocytes.
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| Title: | mTOR activation induces endolysosomal remodeling and nonclassical secretion of IL-32 via exosomes in inflammatory reactive astrocytes. |
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| Authors: | Leng K; Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA. kun.leng@ucsf.edu.; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA. kun.leng@ucsf.edu.; Medical Scientist Training Program, University of California, San Francisco, San Francisco, CA, USA. kun.leng@ucsf.edu., Rooney B; Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA., McCarthy F; Chan Zuckerberg Biohub, San Francisco, CA, USA., Xia W; Departments of Neurology and Pediatrics, School of Medicine, University of California, San Francisco, CA, USA., Rose IVL; Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA.; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA, USA.; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA., Bax S; Chan Zuckerberg Biohub, San Francisco, CA, USA., Chin M; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.; Small Molecule Discovery Center, Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA., Fathi S; Medical Scientist Training Program, University of California, San Francisco, San Francisco, CA, USA., Herrington KA; Center for Advanced Microscopy, University of California, San Francisco, San Francisco, CA, USA., Leonetti M; Chan Zuckerberg Biohub, San Francisco, CA, USA., Kao A; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA., Fancy SPJ; Departments of Neurology and Pediatrics, School of Medicine, University of California, San Francisco, CA, USA., Elias JE; Chan Zuckerberg Biohub, San Francisco, CA, USA., Kampmann M; Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA. martin.kampmann@ucsf.edu.; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA. martin.kampmann@ucsf.edu.; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA. martin.kampmann@ucsf.edu. |
| Source: | Journal of neuroinflammation [J Neuroinflammation] 2024 Aug 08; Vol. 21 (1), pp. 198. Date of Electronic Publication: 2024 Aug 08. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101222974 Publication Model: Electronic Cited Medium: Internet ISSN: 1742-2094 (Electronic) Linking ISSN: 17422094 NLM ISO Abbreviation: J Neuroinflammation Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1742-2094 |
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| DOI: | 10.1186/s12974-024-03165-w |
