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mTOR activation induces endolysosomal remodeling and nonclassical secretion of IL-32 via exosomes in inflammatory reactive astrocytes.

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Title: mTOR activation induces endolysosomal remodeling and nonclassical secretion of IL-32 via exosomes in inflammatory reactive astrocytes.
Authors: Leng K; Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA. kun.leng@ucsf.edu.; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA. kun.leng@ucsf.edu.; Medical Scientist Training Program, University of California, San Francisco, San Francisco, CA, USA. kun.leng@ucsf.edu., Rooney B; Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA., McCarthy F; Chan Zuckerberg Biohub, San Francisco, CA, USA., Xia W; Departments of Neurology and Pediatrics, School of Medicine, University of California, San Francisco, CA, USA., Rose IVL; Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA.; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA, USA.; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA., Bax S; Chan Zuckerberg Biohub, San Francisco, CA, USA., Chin M; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.; Small Molecule Discovery Center, Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA., Fathi S; Medical Scientist Training Program, University of California, San Francisco, San Francisco, CA, USA., Herrington KA; Center for Advanced Microscopy, University of California, San Francisco, San Francisco, CA, USA., Leonetti M; Chan Zuckerberg Biohub, San Francisco, CA, USA., Kao A; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA., Fancy SPJ; Departments of Neurology and Pediatrics, School of Medicine, University of California, San Francisco, CA, USA., Elias JE; Chan Zuckerberg Biohub, San Francisco, CA, USA., Kampmann M; Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA. martin.kampmann@ucsf.edu.; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA. martin.kampmann@ucsf.edu.; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA. martin.kampmann@ucsf.edu.
Source: Journal of neuroinflammation [J Neuroinflammation] 2024 Aug 08; Vol. 21 (1), pp. 198. Date of Electronic Publication: 2024 Aug 08.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101222974 Publication Model: Electronic Cited Medium: Internet ISSN: 1742-2094 (Electronic) Linking ISSN: 17422094 NLM ISO Abbreviation: J Neuroinflammation Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: mTOR activation induces endolysosomal remodeling and nonclassical secretion of IL-32 via exosomes in inflammatory reactive astrocytes.
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  Data: <searchLink fieldCode="AU" term="%22Leng+K%22">Leng K</searchLink>; Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA. kun.leng@ucsf.edu.; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA. kun.leng@ucsf.edu.; Medical Scientist Training Program, University of California, San Francisco, San Francisco, CA, USA. kun.leng@ucsf.edu.<br /><searchLink fieldCode="AU" term="%22Rooney+B%22">Rooney B</searchLink>; Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22McCarthy+F%22">McCarthy F</searchLink>; Chan Zuckerberg Biohub, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Xia+W%22">Xia W</searchLink>; Departments of Neurology and Pediatrics, School of Medicine, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rose+IVL%22">Rose IVL</searchLink>; Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA.; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA, USA.; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bax+S%22">Bax S</searchLink>; Chan Zuckerberg Biohub, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chin+M%22">Chin M</searchLink>; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.; Small Molecule Discovery Center, Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Fathi+S%22">Fathi S</searchLink>; Medical Scientist Training Program, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Herrington+KA%22">Herrington KA</searchLink>; Center for Advanced Microscopy, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Leonetti+M%22">Leonetti M</searchLink>; Chan Zuckerberg Biohub, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kao+A%22">Kao A</searchLink>; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Fancy+SPJ%22">Fancy SPJ</searchLink>; Departments of Neurology and Pediatrics, School of Medicine, University of California, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Elias+JE%22">Elias JE</searchLink>; Chan Zuckerberg Biohub, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kampmann+M%22">Kampmann M</searchLink>; Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA. martin.kampmann@ucsf.edu.; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA. martin.kampmann@ucsf.edu.; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA. martin.kampmann@ucsf.edu.
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  Data: <searchLink fieldCode="JN" term="%22101222974%22">Journal of neuroinflammation</searchLink> [J Neuroinflammation] 2024 Aug 08; Vol. 21 (1), pp. 198. <i>Date of Electronic Publication: </i>2024 Aug 08.
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