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Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4.

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Title: Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4.
Authors: Ashton TD; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia., Calic PPS; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia., Dans MG; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia., Ooi ZK; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia., Zhou Q; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia., Palandri J; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia., Loi K; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia., Jarman KE; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia., Qiu D; Research School of Biology, Australian National University, Canberra 2601, Australia., Lehane AM; Research School of Biology, Australian National University, Canberra 2601, Australia., Maity BC; TCG Lifesciences, Kolkata, West Bengal 700091, India., De N; TCG Lifesciences, Kolkata, West Bengal 700091, India., Giannangelo C; Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia., MacRaild CA; Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia., Creek DJ; Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia., Mao EY; Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide 5005, Australia., Gancheva MR; Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide 5005, Australia., Wilson DW; Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide 5005, Australia., Chowdury M; School of Medicine, Deakin University, Waurn Ponds, Victoria 3216, Australia.; Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, Victoria 3216, Australia., de Koning-Ward TF; School of Medicine, Deakin University, Waurn Ponds, Victoria 3216, Australia.; Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, Victoria 3216, Australia., Famodimu MT; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, U.K., Delves MJ; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, U.K., Pollard H; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, U.K., Sutherland CJ; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, U.K., Baud D; MMV Medicines for Malaria Venture, ICC, Route de Pré-Bois 20, Geneva 1215, Switzerland., Brand S; MMV Medicines for Malaria Venture, ICC, Route de Pré-Bois 20, Geneva 1215, Switzerland., Jackson PF; Emerging Science & Innovation, Discovery Sciences, Janssen R&D LLC, La Jolla, California 92121, United States., Cowman AF; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia., Sleebs BE; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.
Source: Journal of medicinal chemistry [J Med Chem] 2024 Aug 22; Vol. 67 (16), pp. 14493-14523. Date of Electronic Publication: 2024 Aug 12.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Ashton+TD%22">Ashton TD</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Calic+PPS%22">Calic PPS</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Dans+MG%22">Dans MG</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Ooi+ZK%22">Ooi ZK</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Zhou+Q%22">Zhou Q</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Palandri+J%22">Palandri J</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Loi+K%22">Loi K</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Jarman+KE%22">Jarman KE</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Qiu+D%22">Qiu D</searchLink>; Research School of Biology, Australian National University, Canberra 2601, Australia.<br /><searchLink fieldCode="AU" term="%22Lehane+AM%22">Lehane AM</searchLink>; Research School of Biology, Australian National University, Canberra 2601, Australia.<br /><searchLink fieldCode="AU" term="%22Maity+BC%22">Maity BC</searchLink>; TCG Lifesciences, Kolkata, West Bengal 700091, India.<br /><searchLink fieldCode="AU" term="%22De+N%22">De N</searchLink>; TCG Lifesciences, Kolkata, West Bengal 700091, India.<br /><searchLink fieldCode="AU" term="%22Giannangelo+C%22">Giannangelo C</searchLink>; Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.<br /><searchLink fieldCode="AU" term="%22MacRaild+CA%22">MacRaild CA</searchLink>; Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Creek+DJ%22">Creek DJ</searchLink>; Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.<br /><searchLink fieldCode="AU" term="%22Mao+EY%22">Mao EY</searchLink>; Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide 5005, Australia.<br /><searchLink fieldCode="AU" term="%22Gancheva+MR%22">Gancheva MR</searchLink>; Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide 5005, Australia.<br /><searchLink fieldCode="AU" term="%22Wilson+DW%22">Wilson DW</searchLink>; Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide 5005, Australia.<br /><searchLink fieldCode="AU" term="%22Chowdury+M%22">Chowdury M</searchLink>; School of Medicine, Deakin University, Waurn Ponds, Victoria 3216, Australia.; Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, Victoria 3216, Australia.<br /><searchLink fieldCode="AU" term="%22de+Koning-Ward+TF%22">de Koning-Ward TF</searchLink>; School of Medicine, Deakin University, Waurn Ponds, Victoria 3216, Australia.; Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, Victoria 3216, Australia.<br /><searchLink fieldCode="AU" term="%22Famodimu+MT%22">Famodimu MT</searchLink>; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, U.K.<br /><searchLink fieldCode="AU" term="%22Delves+MJ%22">Delves MJ</searchLink>; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, U.K.<br /><searchLink fieldCode="AU" term="%22Pollard+H%22">Pollard H</searchLink>; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, U.K.<br /><searchLink fieldCode="AU" term="%22Sutherland+CJ%22">Sutherland CJ</searchLink>; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, U.K.<br /><searchLink fieldCode="AU" term="%22Baud+D%22">Baud D</searchLink>; MMV Medicines for Malaria Venture, ICC, Route de Pré-Bois 20, Geneva 1215, Switzerland.<br /><searchLink fieldCode="AU" term="%22Brand+S%22">Brand S</searchLink>; MMV Medicines for Malaria Venture, ICC, Route de Pré-Bois 20, Geneva 1215, Switzerland.<br /><searchLink fieldCode="AU" term="%22Jackson+PF%22">Jackson PF</searchLink>; Emerging Science & Innovation, Discovery Sciences, Janssen R&D LLC, La Jolla, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Cowman+AF%22">Cowman AF</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Sleebs+BE%22">Sleebs BE</searchLink>; The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2024 Aug 22; Vol. 67 (16), pp. 14493-14523. <i>Date of Electronic Publication: </i>2024 Aug 12.
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