Sotrovimab lost neutralization efficacy against SARS-CoV-2 subvariants but remained clinically effective: Were monoclonal antibodies against COVID-19 rejected too early?

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Title: Sotrovimab lost neutralization efficacy against SARS-CoV-2 subvariants but remained clinically effective: Were monoclonal antibodies against COVID-19 rejected too early?
Authors: Bang LL; Department of Clinical Microbiology, Odense University Hospital, and Research Unit of Clinical Microbiology, University of Southern Denmark, Odense, Denmark. Electronic address: llbang@health.sdu.dk., Madsen LW; Department of Infectious Diseases, Odense University Hospital and Research Unit for Infectious Diseases, University of Southern Denmark, Odense, Denmark; Unit for Infectious Diseases, Department of Medicine, Sygehus Lillebælt, Kolding, Denmark; Department of Regional Health Research, University of Southern Denmark, Denmark. Electronic address: Lone.Wulff.Madsen@rsyd.dk., Pedersen RM; Department of Clinical Microbiology, Odense University Hospital, and Research Unit of Clinical Microbiology, University of Southern Denmark, Odense, Denmark. Electronic address: rune.pedersen@rsyd.dk., Nilsson AC; Department of Clinical Immunology, Odense University Hospital, and Research Unit for Clinical Immunology, University of Southern Denmark, Odense, Denmark. Electronic address: christine.nilsson@rsyd.dk., Johansen IS; Department of Infectious Diseases, Odense University Hospital and Research Unit for Infectious Diseases, University of Southern Denmark, Odense, Denmark. Electronic address: Isik.Somuncu.Johansen@rsyd.dk., Andersen TE; Department of Clinical Microbiology, Odense University Hospital, and Research Unit for Clinical Microbiology, University of Southern Denmark, Odense, Denmark. Electronic address: thandersen@health.sdu.dk.
Source: Journal of infection and public health [J Infect Public Health] 2024 Sep; Vol. 17 (9), pp. 102512. Date of Electronic Publication: 2024 Aug 07.
Publication Type: Letter
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101487384 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-035X (Electronic) Linking ISSN: 18760341 NLM ISO Abbreviation: J Infect Public Health Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Sotrovimab lost neutralization efficacy against SARS-CoV-2 subvariants but remained clinically effective: Were monoclonal antibodies against COVID-19 rejected too early?
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  Data: <searchLink fieldCode="AU" term="%22Bang+LL%22">Bang LL</searchLink>; Department of Clinical Microbiology, Odense University Hospital, and Research Unit of Clinical Microbiology, University of Southern Denmark, Odense, Denmark. Electronic address: llbang@health.sdu.dk.<br /><searchLink fieldCode="AU" term="%22Madsen+LW%22">Madsen LW</searchLink>; Department of Infectious Diseases, Odense University Hospital and Research Unit for Infectious Diseases, University of Southern Denmark, Odense, Denmark; Unit for Infectious Diseases, Department of Medicine, Sygehus Lillebælt, Kolding, Denmark; Department of Regional Health Research, University of Southern Denmark, Denmark. Electronic address: Lone.Wulff.Madsen@rsyd.dk.<br /><searchLink fieldCode="AU" term="%22Pedersen+RM%22">Pedersen RM</searchLink>; Department of Clinical Microbiology, Odense University Hospital, and Research Unit of Clinical Microbiology, University of Southern Denmark, Odense, Denmark. Electronic address: rune.pedersen@rsyd.dk.<br /><searchLink fieldCode="AU" term="%22Nilsson+AC%22">Nilsson AC</searchLink>; Department of Clinical Immunology, Odense University Hospital, and Research Unit for Clinical Immunology, University of Southern Denmark, Odense, Denmark. Electronic address: christine.nilsson@rsyd.dk.<br /><searchLink fieldCode="AU" term="%22Johansen+IS%22">Johansen IS</searchLink>; Department of Infectious Diseases, Odense University Hospital and Research Unit for Infectious Diseases, University of Southern Denmark, Odense, Denmark. Electronic address: Isik.Somuncu.Johansen@rsyd.dk.<br /><searchLink fieldCode="AU" term="%22Andersen+TE%22">Andersen TE</searchLink>; Department of Clinical Microbiology, Odense University Hospital, and Research Unit for Clinical Microbiology, University of Southern Denmark, Odense, Denmark. Electronic address: thandersen@health.sdu.dk.
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  Data: <searchLink fieldCode="JN" term="%22101487384%22">Journal of infection and public health</searchLink> [J Infect Public Health] 2024 Sep; Vol. 17 (9), pp. 102512. <i>Date of Electronic Publication: </i>2024 Aug 07.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101487384 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1876-035X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2218760341%22">18760341 </searchLink><i>NLM ISO Abbreviation: </i>J Infect Public Health <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.jiph.2024.102512
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        Text: English
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        StartPage: 102512
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      – TitleFull: Sotrovimab lost neutralization efficacy against SARS-CoV-2 subvariants but remained clinically effective: Were monoclonal antibodies against COVID-19 rejected too early?
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              M: 09
              Text: 2024 Sep
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              Y: 2024
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