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Dynamic PET reveals compartmentalized brain and lung tissue antibiotic exposures of tuberculosis drugs.

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Title: Dynamic PET reveals compartmentalized brain and lung tissue antibiotic exposures of tuberculosis drugs.
Authors: Chen X; Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Arun B; Center for Translational Medicine, University of Maryland School of Pharmacy, Baltimore, MD, USA., Nino-Meza OJ; Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Sarhan MO; Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Singh M; Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Jeon B; Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Mane K; Department of Pharmacology, Physiology, and Neuroscience, Rutgers New Jersey Medical School, Newark, NJ, USA., Shah M; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Tucker EW; Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Carroll LS; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Freundlich JS; Department of Pharmacology, Physiology, and Neuroscience, Rutgers New Jersey Medical School, Newark, NJ, USA., Peloquin CA; Infectious Disease Pharmacokinetics Laboratory, Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, Gainesville, FL, USA., Ivaturi VD; Center for Translational Medicine, University of Maryland School of Pharmacy, Baltimore, MD, USA.; Centre for Pharmacometrics, Manipal University, Manipal, Karnataka, India., Jain SK; Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA. sjain5@jhmi.edu.; Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA. sjain5@jhmi.edu.; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA. sjain5@jhmi.edu.; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA. sjain5@jhmi.edu.
Source: Nature communications [Nat Commun] 2024 Aug 14; Vol. 15 (1), pp. 6657. Date of Electronic Publication: 2024 Aug 14.
Publication Type: Journal Article; Observational Study; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Dynamic PET reveals compartmentalized brain and lung tissue antibiotic exposures of tuberculosis drugs.
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