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Integrating molecular dynamics simulation with small- and wide-angle X-ray scattering to unravel the flexibility, antigen-blocking, and protease-restoring functions in a hindrance-based pro-antibody.

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Title: Integrating molecular dynamics simulation with small- and wide-angle X-ray scattering to unravel the flexibility, antigen-blocking, and protease-restoring functions in a hindrance-based pro-antibody.
Authors: Liao JM; Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan., Hong ST; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan., Wang YT; Department of Biochemistry, Kaohsiung Medical University, Kaohsiung, Taiwan., Cheng YA; Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, Taiwan.; Precisemab Biotech Co. Ltd, Taipei, Taiwan., Ho KW; Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan., Toh SI; Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan., Shih O; National Synchrotron Radiation Research Center, Hsinchu Science Park, Hsinchu, Taiwan., Jeng US; National Synchrotron Radiation Research Center, Hsinchu Science Park, Hsinchu, Taiwan.; Department of Chemical Engineering &College of Semiconductor Research, National Tsing Hua University, Hsinchu, Taiwan., Lyu PC; Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, Taiwan., Hu IC; Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, Taiwan., Huang MY; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Radiation Oncology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan., Chang CY; Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan.; Center for Intelligent Drug Systems and Smart Bio-devices, National Yang Ming Chiao Tung University, Hsinchu, Taiwan., Cheng TL; Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan.; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, Taiwan.; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Source: Protein science : a publication of the Protein Society [Protein Sci] 2024 Sep; Vol. 33 (9), pp. e5124.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9211750 Publication Model: Print Cited Medium: Internet ISSN: 1469-896X (Electronic) Linking ISSN: 09618368 NLM ISO Abbreviation: Protein Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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