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Neoadjuvant cabozantinib restores CD8+ T cells in patients with locally advanced non-metastatic clear cell renal cell carcinoma: a phase 2 trial.

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Title: Neoadjuvant cabozantinib restores CD8+ T cells in patients with locally advanced non-metastatic clear cell renal cell carcinoma: a phase 2 trial.
Authors: Bilen MA; Winship Cancer Institute, Emory University, Atlanta, GA, USA.; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA., Vo BT; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA., Liu Y; Winship Cancer Institute, Emory University, Atlanta, GA, USA.; Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Greenwald R; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA., Davarpanah AH; Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, USA., McGuire D; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.; Emory Vaccine Center, Emory University, Atlanta, GA, USA., Shiradkar R; Winship Cancer Institute, Emory University, Atlanta, GA, USA.; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA., Li L; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA., Nazha B; Winship Cancer Institute, Emory University, Atlanta, GA, USA.; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA., Brown JT; Winship Cancer Institute, Emory University, Atlanta, GA, USA.; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA., Williams S; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA., Session W; Winship Cancer Institute, Emory University, Atlanta, GA, USA., Russler G; Winship Cancer Institute, Emory University, Atlanta, GA, USA., Caulfield S; Winship Cancer Institute, Emory University, Atlanta, GA, USA.; Department of Pharmaceutical Services, Emory University School of Medicine, Atlanta, GA, USA., Joshi SS; Winship Cancer Institute, Emory University, Atlanta, GA, USA.; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA., Narayan VM; Winship Cancer Institute, Emory University, Atlanta, GA, USA.; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA., Filson CP; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA., Ogan K; Winship Cancer Institute, Emory University, Atlanta, GA, USA.; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA., Kucuk O; Winship Cancer Institute, Emory University, Atlanta, GA, USA.; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA., Carthon BC; Winship Cancer Institute, Emory University, Atlanta, GA, USA.; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA., Del Balzo L; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA., Cohen A; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA., Boyanton A; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA., Prokhnevska N; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA., Cardenas MA; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA., Sobierajska E; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA., Jansen CS; Winship Cancer Institute, Emory University, Atlanta, GA, USA.; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA., Patil DH; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA., Nicaise E; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA., Osunkoya AO; Winship Cancer Institute, Emory University, Atlanta, GA, USA.; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA.; Department of Pathology, Emory University School of Medicine, Atlanta, GA, USA., Kissick H; Winship Cancer Institute, Emory University, Atlanta, GA, USA.; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA.; Emory Vaccine Center, Emory University, Atlanta, GA, USA., Master VA; Winship Cancer Institute, Emory University, Atlanta, GA, USA.; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA.
Source: Research square [Res Sq] 2024 Aug 08. Date of Electronic Publication: 2024 Aug 08.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Neoadjuvant cabozantinib restores CD8+ T cells in patients with locally advanced non-metastatic clear cell renal cell carcinoma: a phase 2 trial.
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  Data: <searchLink fieldCode="AU" term="%22Bilen+MA%22">Bilen MA</searchLink>; Winship Cancer Institute, Emory University, Atlanta, GA, USA.; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Vo+BT%22">Vo BT</searchLink>; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Winship Cancer Institute, Emory University, Atlanta, GA, USA.; Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Greenwald+R%22">Greenwald R</searchLink>; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Davarpanah+AH%22">Davarpanah AH</searchLink>; Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22McGuire+D%22">McGuire D</searchLink>; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.; Emory Vaccine Center, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Shiradkar+R%22">Shiradkar R</searchLink>; Winship Cancer Institute, Emory University, Atlanta, GA, USA.; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Nazha+B%22">Nazha B</searchLink>; Winship Cancer Institute, Emory University, Atlanta, GA, USA.; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Brown+JT%22">Brown JT</searchLink>; Winship Cancer Institute, Emory University, Atlanta, GA, USA.; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Williams+S%22">Williams S</searchLink>; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Session+W%22">Session W</searchLink>; Winship Cancer Institute, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Russler+G%22">Russler G</searchLink>; Winship Cancer Institute, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Caulfield+S%22">Caulfield S</searchLink>; Winship Cancer Institute, Emory University, Atlanta, GA, USA.; Department of Pharmaceutical Services, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Joshi+SS%22">Joshi SS</searchLink>; Winship Cancer Institute, Emory University, Atlanta, GA, USA.; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Narayan+VM%22">Narayan VM</searchLink>; Winship Cancer Institute, Emory University, Atlanta, GA, USA.; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Filson+CP%22">Filson CP</searchLink>; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Ogan+K%22">Ogan K</searchLink>; Winship Cancer Institute, Emory University, Atlanta, GA, USA.; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Kucuk+O%22">Kucuk O</searchLink>; Winship Cancer Institute, Emory University, Atlanta, GA, USA.; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Carthon+BC%22">Carthon BC</searchLink>; Winship Cancer Institute, Emory University, Atlanta, GA, USA.; Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Del+Balzo+L%22">Del Balzo L</searchLink>; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Cohen+A%22">Cohen A</searchLink>; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Boyanton+A%22">Boyanton A</searchLink>; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Prokhnevska+N%22">Prokhnevska N</searchLink>; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Cardenas+MA%22">Cardenas MA</searchLink>; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Sobierajska+E%22">Sobierajska E</searchLink>; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Jansen+CS%22">Jansen CS</searchLink>; Winship Cancer Institute, Emory University, Atlanta, GA, USA.; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Patil+DH%22">Patil DH</searchLink>; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Nicaise+E%22">Nicaise E</searchLink>; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Osunkoya+AO%22">Osunkoya AO</searchLink>; Winship Cancer Institute, Emory University, Atlanta, GA, USA.; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA.; Department of Pathology, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Kissick+H%22">Kissick H</searchLink>; Winship Cancer Institute, Emory University, Atlanta, GA, USA.; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA.; Emory Vaccine Center, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Master+VA%22">Master VA</searchLink>; Winship Cancer Institute, Emory University, Atlanta, GA, USA.; Department of Urology, Emory University School of Medicine, Atlanta, GA, USA.
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