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Modified C-type natriuretic peptide normalizes tumor vasculature, reinvigorates antitumor immunity, and improves solid tumor therapies.

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Title: Modified C-type natriuretic peptide normalizes tumor vasculature, reinvigorates antitumor immunity, and improves solid tumor therapies.
Authors: Lu Z; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Verginadis I; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Kumazoe M; Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 819-0395, Japan., Castillo GM; PharmaIN Corp., Bothell, WA 98011, USA., Yao Y; PharmaIN Corp., Bothell, WA 98011, USA., Guerra RE; PharmaIN Corp., Bothell, WA 98011, USA., Bicher S; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., You M; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., McClung G; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Qiu R; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Xiao Z; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Miao Z; Department of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA., George SS; Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Beiting DP; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Nojiri T; Department of General Thoracic Surgery, Higashiosaka City Medical Center, Higashiosaka 578-8588, Japan., Tanaka Y; Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 819-0395, Japan., Fujimura Y; Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 819-0395, Japan., Onda H; Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 819-0395, Japan., Hatakeyama Y; Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 819-0395, Japan., Nishimoto-Ashfield A; PharmaIN Corp., Bothell, WA 98011, USA., Bykova K; PharmaIN Corp., Bothell, WA 98011, USA., Guo W; Department of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA., Fan Y; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Buynov NM; PharmaIN Corp., Bothell, WA 98011, USA., Diehl JA; Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA., Stanger BZ; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Tachibana H; Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 819-0395, Japan., Gade TP; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Puré E; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Koumenis C; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Bolotin EM; PharmaIN Corp., Bothell, WA 98011, USA., Fuchs SY; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Source: Science translational medicine [Sci Transl Med] 2024 Aug 21; Vol. 16 (761), pp. eadn0904. Date of Electronic Publication: 2024 Aug 21.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
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  Data: Modified C-type natriuretic peptide normalizes tumor vasculature, reinvigorates antitumor immunity, and improves solid tumor therapies.
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Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 819-0395, Japan.<br /><searchLink fieldCode="AU" term="%22Hatakeyama+Y%22">Hatakeyama Y</searchLink>; Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 819-0395, Japan.<br /><searchLink fieldCode="AU" term="%22Nishimoto-Ashfield+A%22">Nishimoto-Ashfield A</searchLink>; PharmaIN Corp., Bothell, WA 98011, USA.<br /><searchLink fieldCode="AU" term="%22Bykova+K%22">Bykova K</searchLink>; PharmaIN Corp., Bothell, WA 98011, USA.<br /><searchLink fieldCode="AU" term="%22Guo+W%22">Guo W</searchLink>; Department of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Fan+Y%22">Fan Y</searchLink>; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Buynov+NM%22">Buynov NM</searchLink>; PharmaIN Corp., Bothell, WA 98011, USA.<br /><searchLink fieldCode="AU" term="%22Diehl+JA%22">Diehl JA</searchLink>; Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.<br /><searchLink fieldCode="AU" term="%22Stanger+BZ%22">Stanger BZ</searchLink>; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Tachibana+H%22">Tachibana H</searchLink>; Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 819-0395, Japan.<br /><searchLink fieldCode="AU" term="%22Gade+TP%22">Gade TP</searchLink>; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Puré+E%22">Puré E</searchLink>; Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Koumenis+C%22">Koumenis C</searchLink>; 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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2024 Aug 21; Vol. 16 (761), pp. eadn0904. <i>Date of Electronic Publication: </i>2024 Aug 21.
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