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Identification and multimodal characterization of a specialized epithelial cell type associated with Crohn's disease.

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Title: Identification and multimodal characterization of a specialized epithelial cell type associated with Crohn's disease.
Authors: Li J; Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., Simmons AJ; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Hawkins CV; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Chiron S; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Ramirez-Solano MA; Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., Tasneem N; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Kaur H; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Program in Chemical and Physical Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Xu Y; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Revetta F; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Vega PN; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Bao S; Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, USA., Cui C; Department of Computer Science, Vanderbilt University, Nashville, TN, USA., Tyree RN; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Raber LW; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Conner AN; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Pilat JM; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Jacobse J; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., McNamara KM; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Allaman MM; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Raffa GA; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Gobert AP; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, USA., Asim M; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Goettel JA; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, USA., Choksi YA; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, USA.; Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN, USA., Beaulieu DB; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Dalal RL; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Horst SN; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Pabla BS; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Huo Y; Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, USA.; Department of Computer Science, Vanderbilt University, Nashville, TN, USA., Landman BA; Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, USA.; Department of Computer Science, Vanderbilt University, Nashville, TN, USA., Roland JT; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA., Scoville EA; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, USA., Schwartz DA; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Washington MK; Program in Chemical and Physical Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, USA., Shyr Y; Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., Wilson KT; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. keith.wilson@vumc.org.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA. keith.wilson@vumc.org.; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, USA. keith.wilson@vumc.org.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, USA. keith.wilson@vumc.org.; Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN, USA. keith.wilson@vumc.org., Coburn LA; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. lori.coburn@vumc.org.; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, USA. lori.coburn@vumc.org.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, USA. lori.coburn@vumc.org.; Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN, USA. lori.coburn@vumc.org., Lau KS; Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN, USA. ken.s.lau@vanderbilt.edu.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA. ken.s.lau@vanderbilt.edu.; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA. ken.s.lau@vanderbilt.edu.; Program in Chemical and Physical Biology, Vanderbilt University School of Medicine, Nashville, TN, USA. ken.s.lau@vanderbilt.edu.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, USA. ken.s.lau@vanderbilt.edu.; Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA. ken.s.lau@vanderbilt.edu., Liu Q; Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN, USA. qi.liu@vumc.org.; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA. qi.liu@vumc.org.
Source: Nature communications [Nat Commun] 2024 Aug 22; Vol. 15 (1), pp. 7204. Date of Electronic Publication: 2024 Aug 22.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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