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NAD+ precursors prolong survival and improve cardiac phenotypes in a mouse model of Friedreich's Ataxia.

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Title: NAD+ precursors prolong survival and improve cardiac phenotypes in a mouse model of Friedreich's Ataxia.
Authors: Perry CE; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Halawani SM; Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Mukherjee S; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Ngaba LV; Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Lieu M; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Lee WD; Department of Chemistry, Princeton University, Princeton, New Jersey, USA., Davis JG; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Adzika GK; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Bebenek AN; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Bazianos DD; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Chen B; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Mercado-Ayon E; Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Flatley LP; Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Suryawanshi AP; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Ho I; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Rabinowitz JD; Department of Chemistry, Princeton University, Princeton, New Jersey, USA., Serai SD; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Department of Radiology and., Biko DM; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Department of Radiology and., Tamaroff J; Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Division of Pediatric Endocrinology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., DeDio A; Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Wade K; Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Lin KY; Division of Pediatric Cardiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Livingston DJ; Metro International Biotech, Worcester, Massachusetts, USA., McCormack SE; Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Lynch DR; Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Baur JA; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Source: JCI insight [JCI Insight] 2024 Jul 18; Vol. 9 (16). Date of Electronic Publication: 2024 Jul 18.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: NAD+ precursors prolong survival and improve cardiac phenotypes in a mouse model of Friedreich's Ataxia.
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  Data: <searchLink fieldCode="AU" term="%22Perry+CE%22">Perry CE</searchLink>; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Halawani+SM%22">Halawani SM</searchLink>; Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Mukherjee+S%22">Mukherjee S</searchLink>; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Ngaba+LV%22">Ngaba LV</searchLink>; Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Lieu+M%22">Lieu M</searchLink>; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Lee+WD%22">Lee WD</searchLink>; Department of Chemistry, Princeton University, Princeton, New Jersey, USA.<br /><searchLink fieldCode="AU" term="%22Davis+JG%22">Davis JG</searchLink>; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Adzika+GK%22">Adzika GK</searchLink>; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Bebenek+AN%22">Bebenek AN</searchLink>; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Bazianos+DD%22">Bazianos DD</searchLink>; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Chen+B%22">Chen B</searchLink>; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Mercado-Ayon+E%22">Mercado-Ayon E</searchLink>; 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Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Livingston+DJ%22">Livingston DJ</searchLink>; Metro International Biotech, Worcester, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22McCormack+SE%22">McCormack SE</searchLink>; Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Lynch+DR%22">Lynch DR</searchLink>; Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Baur+JA%22">Baur JA</searchLink>; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
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