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A single-dose intranasal live-attenuated codon deoptimized vaccine provides broad protection against SARS-CoV-2 and its variants.

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Title: A single-dose intranasal live-attenuated codon deoptimized vaccine provides broad protection against SARS-CoV-2 and its variants.
Authors: Liu X; Emerging Viruses, Inflammation and Therapeutics Group, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, Australia.; Global Virus Network (GVN) Centre of Excellence in Arboviruses, Griffith University, Gold Coast, QLD, Australia.; School of Pharmacy and Medical Sciences, Griffith University, Gold Coast, QLD, Australia., Ng WH; Emerging Viruses, Inflammation and Therapeutics Group, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, Australia.; Global Virus Network (GVN) Centre of Excellence in Arboviruses, Griffith University, Gold Coast, QLD, Australia.; School of Pharmacy and Medical Sciences, Griffith University, Gold Coast, QLD, Australia., Zusinaite E; Institute of Technology, University of Tartu, 50411, Tartu, Estonia., Freitas J; Emerging Viruses, Inflammation and Therapeutics Group, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, Australia.; Global Virus Network (GVN) Centre of Excellence in Arboviruses, Griffith University, Gold Coast, QLD, Australia.; School of Pharmacy and Medical Sciences, Griffith University, Gold Coast, QLD, Australia., Taylor A; Emerging Viruses, Inflammation and Therapeutics Group, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, Australia.; Global Virus Network (GVN) Centre of Excellence in Arboviruses, Griffith University, Gold Coast, QLD, Australia.; School of Pharmacy and Medical Sciences, Griffith University, Gold Coast, QLD, Australia., Yerragunta V; Indian Immunologicals Ltd (IIL), Rakshapuram, Gachibowli Post, Hyderabad, 500032, Telangana, India., Aavula SM; Indian Immunologicals Ltd (IIL), Rakshapuram, Gachibowli Post, Hyderabad, 500032, Telangana, India., Gorriparthi S; Indian Immunologicals Ltd (IIL), Rakshapuram, Gachibowli Post, Hyderabad, 500032, Telangana, India., Ponsekaran S; Indian Immunologicals Ltd (IIL), Rakshapuram, Gachibowli Post, Hyderabad, 500032, Telangana, India., Bonda RL; Indian Immunologicals Ltd (IIL), Rakshapuram, Gachibowli Post, Hyderabad, 500032, Telangana, India., Mani P; Indian Immunologicals Ltd (IIL), Rakshapuram, Gachibowli Post, Hyderabad, 500032, Telangana, India., Nimmagadda SV; Indian Immunologicals Ltd (IIL), Rakshapuram, Gachibowli Post, Hyderabad, 500032, Telangana, India., Wang S; Institute of Technology, University of Tartu, 50411, Tartu, Estonia., Lello LS; Institute of Technology, University of Tartu, 50411, Tartu, Estonia., Zaid A; Emerging Viruses, Inflammation and Therapeutics Group, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, Australia.; Global Virus Network (GVN) Centre of Excellence in Arboviruses, Griffith University, Gold Coast, QLD, Australia.; School of Pharmacy and Medical Sciences, Griffith University, Gold Coast, QLD, Australia., Dua U; Emerging Viruses, Inflammation and Therapeutics Group, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, Australia.; Griffith Enterprise, Griffith University, Brisbane, QLD, Australia., Taft-Benz SA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Anderson E; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Baxter VK; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Sarkar S; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Ling ZL; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia., Ashhurst TM; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia.; Sydney Cytometry Core Research Facility, The University of Sydney and Centenary Institute, Sydney, NSW, Australia., Cheng SMS; School of Public Health, The University of Hong Kong, Special Administrative Region of Hong Kong, Hong Kong, China., Pattnaik P; Indian Immunologicals Ltd (IIL), Rakshapuram, Gachibowli Post, Hyderabad, 500032, Telangana, India., Kanakasapapathy AK; Indian Immunologicals Ltd (IIL), Rakshapuram, Gachibowli Post, Hyderabad, 500032, Telangana, India., Baric RS; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Burt FJ; Division of Virology, National Health Laboratory Service and Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa., Peiris M; School of Public Health, The University of Hong Kong, Special Administrative Region of Hong Kong, Hong Kong, China.; HKU-Pasteur Research Pole, The University of Hong Kong, Special Administrative Region of Hong Kong, Hong Kong, China., Heise MT; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., King NJC; Emerging Viruses, Inflammation and Therapeutics Group, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, Australia.; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia.; Viral Immunopathology Laboratory, The Charles Perkins Centre, The University of Sydney, Sydney, NSW 2006, Australia.; Sydney Institute for Infectious Diseases, The University of Sydney, Sydney, NSW 2006, Australia.; Sydney Nano, The University of Sydney, Sydney, NSW 2006, Australia., Merits A; Institute of Technology, University of Tartu, 50411, Tartu, Estonia., Lingala R; Indian Immunologicals Ltd (IIL), Rakshapuram, Gachibowli Post, Hyderabad, 500032, Telangana, India., Mahalingam S; Emerging Viruses, Inflammation and Therapeutics Group, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, Australia. s.mahalingam@griffith.edu.au.; Global Virus Network (GVN) Centre of Excellence in Arboviruses, Griffith University, Gold Coast, QLD, Australia. s.mahalingam@griffith.edu.au.; School of Pharmacy and Medical Sciences, Griffith University, Gold Coast, QLD, Australia. s.mahalingam@griffith.edu.au.
Source: Nature communications [Nat Commun] 2024 Aug 26; Vol. 15 (1), pp. 7225. Date of Electronic Publication: 2024 Aug 26.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-024-51535-y