An autoimmune transcriptional circuit drives FOXP3+ regulatory T cell dysfunction.
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| Title: | An autoimmune transcriptional circuit drives FOXP3+ regulatory T cell dysfunction. |
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| Authors: | Sumida TS; Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Lincoln MR; Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON M6R 1B5, Canada.; Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON M6R 1B5, Canada., He L; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge, MA 02139, USA.; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC 27705, USA., Park Y; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge, MA 02139, USA., Ota M; Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo 113-8655, Japan., Oguchi A; RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.; Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto 606-8303, Japan., Son R; RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.; Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto 606-8303, Japan., Yi A; Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA., Stillwell HA; Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA., Leissa GA; Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA., Fujio K; Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo 113-8655, Japan., Murakawa Y; RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.; Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto 606-8303, Japan., Kulminski AM; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC 27705, USA., Epstein CB; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Bernstein BE; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA., Kellis M; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge, MA 02139, USA., Hafler DA; Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. |
| Source: | Science translational medicine [Sci Transl Med] 2024 Aug 28; Vol. 16 (762), pp. eadp1720. Date of Electronic Publication: 2024 Aug 28. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1946-6242 |
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| DOI: | 10.1126/scitranslmed.adp1720 |
