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An autoimmune transcriptional circuit drives FOXP3+ regulatory T cell dysfunction.

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Title: An autoimmune transcriptional circuit drives FOXP3+ regulatory T cell dysfunction.
Authors: Sumida TS; Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Lincoln MR; Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON M6R 1B5, Canada.; Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON M6R 1B5, Canada., He L; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge, MA 02139, USA.; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC 27705, USA., Park Y; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge, MA 02139, USA., Ota M; Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo 113-8655, Japan., Oguchi A; RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.; Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto 606-8303, Japan., Son R; RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.; Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto 606-8303, Japan., Yi A; Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA., Stillwell HA; Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA., Leissa GA; Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA., Fujio K; Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo 113-8655, Japan., Murakawa Y; RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.; Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto 606-8303, Japan., Kulminski AM; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC 27705, USA., Epstein CB; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Bernstein BE; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA., Kellis M; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge, MA 02139, USA., Hafler DA; Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Source: Science translational medicine [Sci Transl Med] 2024 Aug 28; Vol. 16 (762), pp. eadp1720. Date of Electronic Publication: 2024 Aug 28.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: An autoimmune transcriptional circuit drives FOXP3<superscript>+</superscript> regulatory T cell dysfunction.
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  Data: <searchLink fieldCode="AU" term="%22Sumida+TS%22">Sumida TS</searchLink>; Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Lincoln+MR%22">Lincoln MR</searchLink>; Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON M6R 1B5, Canada.; Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON M6R 1B5, Canada.<br /><searchLink fieldCode="AU" term="%22He+L%22">He L</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge, MA 02139, USA.; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC 27705, USA.<br /><searchLink fieldCode="AU" term="%22Park+Y%22">Park Y</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Ota+M%22">Ota M</searchLink>; Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo 113-8655, Japan.<br /><searchLink fieldCode="AU" term="%22Oguchi+A%22">Oguchi A</searchLink>; RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.; Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto 606-8303, Japan.<br /><searchLink fieldCode="AU" term="%22Son+R%22">Son R</searchLink>; RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.; Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto 606-8303, Japan.<br /><searchLink fieldCode="AU" term="%22Yi+A%22">Yi A</searchLink>; Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA.<br /><searchLink fieldCode="AU" term="%22Stillwell+HA%22">Stillwell HA</searchLink>; Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA.<br /><searchLink fieldCode="AU" term="%22Leissa+GA%22">Leissa GA</searchLink>; Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA.<br /><searchLink fieldCode="AU" term="%22Fujio+K%22">Fujio K</searchLink>; Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo 113-8655, Japan.<br /><searchLink fieldCode="AU" term="%22Murakawa+Y%22">Murakawa Y</searchLink>; RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.; Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto 606-8303, Japan.<br /><searchLink fieldCode="AU" term="%22Kulminski+AM%22">Kulminski AM</searchLink>; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC 27705, USA.<br /><searchLink fieldCode="AU" term="%22Epstein+CB%22">Epstein CB</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Bernstein+BE%22">Bernstein BE</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Kellis+M%22">Kellis M</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Hafler+DA%22">Hafler DA</searchLink>; Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06510, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2024 Aug 28; Vol. 16 (762), pp. eadp1720. <i>Date of Electronic Publication: </i>2024 Aug 28.
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