TOPORS E3 ligase mediates resistance to hypomethylating agent cytotoxicity in acute myeloid leukemia cells.

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Title: TOPORS E3 ligase mediates resistance to hypomethylating agent cytotoxicity in acute myeloid leukemia cells.
Authors: Truong P; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, NSW, Australia., Shen S; School of Biomedical Sciences, UNSW Sydney, Sydney, NSW, Australia., Joshi S; School of Biomedical Sciences, UNSW Sydney, Sydney, NSW, Australia., Islam MI; School of Biomedical Sciences, UNSW Sydney, Sydney, NSW, Australia., Zhong L; Bioanalytical Mass Spectrometry Facility, Mark Wainwright Analytical Centre, UNSW Sydney, Sydney, NSW, Australia., Raftery MJ; Bioanalytical Mass Spectrometry Facility, Mark Wainwright Analytical Centre, UNSW Sydney, Sydney, NSW, Australia., Afrasiabi A; UNSW BioMedical Machine Learning Lab (BML), The Graduate School of Biomedical Engineering, UNSW Sydney, Sydney, NSW, Australia., Alinejad-Rokny H; UNSW BioMedical Machine Learning Lab (BML), The Graduate School of Biomedical Engineering, UNSW Sydney, Sydney, NSW, Australia.; Tyree Institute of Health Engineering (IHealthE), UNSW Sydney, Sydney, NSW, Australia., Nguyen M; School of Biomedical Sciences, UNSW Sydney, Sydney, NSW, Australia., Zou X; School of Biomedical Sciences, UNSW Sydney, Sydney, NSW, Australia., Bhuyan GS; School of Biomedical Sciences, UNSW Sydney, Sydney, NSW, Australia., Sarowar CH; School of Biomedical Sciences, UNSW Sydney, Sydney, NSW, Australia., Ghodousi ES; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, NSW, Australia., Stonehouse O; School of Biomedical Sciences, UNSW Sydney, Sydney, NSW, Australia., Mohamed S; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, NSW, Australia.; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia.; UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, NSW, Australia., Toscan CE; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, NSW, Australia.; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia.; UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, NSW, Australia., Connerty P; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, NSW, Australia.; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia.; UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, NSW, Australia., Kakadia PM; Leukaemia and Blood Cancer Research Unit, Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand., Bohlander SK; Leukaemia and Blood Cancer Research Unit, Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand., Michie KA; Structural Biology Facility, Mark Wainwright Analytical Centre, UNSW Sydney, Sydney, NSW, Australia., Larsson J; Division of Molecular Medicine and Gene Therapy, Lund Stem Cell Centre, Lund University, Lund, Sweden., Lock RB; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, NSW, Australia.; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia.; UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, NSW, Australia., Walkley CR; St Vincent's Institute of Medical Research, University of Melbourne, Melbourne, VIC, Australia.; Department of Medicine, University of Melbourne, Melbourne, VIC, Australia., Thoms JAI; School of Biomedical Sciences, UNSW Sydney, Sydney, NSW, Australia., Jolly CJ; School of Biomedical Sciences, UNSW Sydney, Sydney, NSW, Australia. c.jolly@unsw.edu.au., Pimanda JE; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, NSW, Australia. jpimanda@unsw.edu.au.; School of Biomedical Sciences, UNSW Sydney, Sydney, NSW, Australia. jpimanda@unsw.edu.au.; Haematology Department, Prince of Wales Hospital, Sydney, NSW, Australia. jpimanda@unsw.edu.au.
Source: Nature communications [Nat Commun] 2024 Aug 28; Vol. 15 (1), pp. 7360. Date of Electronic Publication: 2024 Aug 28.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: TOPORS E3 ligase mediates resistance to hypomethylating agent cytotoxicity in acute myeloid leukemia cells.
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  Data: <searchLink fieldCode="AU" term="%22Truong+P%22">Truong P</searchLink>; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Shen+S%22">Shen S</searchLink>; School of Biomedical Sciences, UNSW Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Joshi+S%22">Joshi S</searchLink>; School of Biomedical Sciences, UNSW Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Islam+MI%22">Islam MI</searchLink>; School of Biomedical Sciences, UNSW Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Zhong+L%22">Zhong L</searchLink>; Bioanalytical Mass Spectrometry Facility, Mark Wainwright Analytical Centre, UNSW Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Raftery+MJ%22">Raftery MJ</searchLink>; Bioanalytical Mass Spectrometry Facility, Mark Wainwright Analytical Centre, UNSW Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Afrasiabi+A%22">Afrasiabi A</searchLink>; UNSW BioMedical Machine Learning Lab (BML), The Graduate School of Biomedical Engineering, UNSW Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Alinejad-Rokny+H%22">Alinejad-Rokny H</searchLink>; UNSW BioMedical Machine Learning Lab (BML), The Graduate School of Biomedical Engineering, UNSW Sydney, Sydney, NSW, Australia.; Tyree Institute of Health Engineering (IHealthE), UNSW Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Nguyen+M%22">Nguyen M</searchLink>; School of Biomedical Sciences, UNSW Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Zou+X%22">Zou X</searchLink>; School of Biomedical Sciences, UNSW Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Bhuyan+GS%22">Bhuyan GS</searchLink>; School of Biomedical Sciences, UNSW Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Sarowar+CH%22">Sarowar CH</searchLink>; School of Biomedical Sciences, UNSW Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Ghodousi+ES%22">Ghodousi ES</searchLink>; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Stonehouse+O%22">Stonehouse O</searchLink>; School of Biomedical Sciences, UNSW Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Mohamed+S%22">Mohamed S</searchLink>; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, NSW, Australia.; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia.; UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Toscan+CE%22">Toscan CE</searchLink>; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, NSW, Australia.; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia.; UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Connerty+P%22">Connerty P</searchLink>; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, NSW, Australia.; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia.; UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Kakadia+PM%22">Kakadia PM</searchLink>; Leukaemia and Blood Cancer Research Unit, Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Bohlander+SK%22">Bohlander SK</searchLink>; Leukaemia and Blood Cancer Research Unit, Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Michie+KA%22">Michie KA</searchLink>; Structural Biology Facility, Mark Wainwright Analytical Centre, UNSW Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Larsson+J%22">Larsson J</searchLink>; Division of Molecular Medicine and Gene Therapy, Lund Stem Cell Centre, Lund University, Lund, Sweden.<br /><searchLink fieldCode="AU" term="%22Lock+RB%22">Lock RB</searchLink>; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, NSW, Australia.; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia.; UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Walkley+CR%22">Walkley CR</searchLink>; St Vincent's Institute of Medical Research, University of Melbourne, Melbourne, VIC, Australia.; Department of Medicine, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Thoms+JAI%22">Thoms JAI</searchLink>; School of Biomedical Sciences, UNSW Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Jolly+CJ%22">Jolly CJ</searchLink>; School of Biomedical Sciences, UNSW Sydney, Sydney, NSW, Australia. c.jolly@unsw.edu.au.<br /><searchLink fieldCode="AU" term="%22Pimanda+JE%22">Pimanda JE</searchLink>; School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, NSW, Australia. jpimanda@unsw.edu.au.; School of Biomedical Sciences, UNSW Sydney, Sydney, NSW, Australia. jpimanda@unsw.edu.au.; Haematology Department, Prince of Wales Hospital, Sydney, NSW, Australia. jpimanda@unsw.edu.au.
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