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Advanced piperazine-containing inhibitors target microbial β-glucuronidases linked to gut toxicity.

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Title: Advanced piperazine-containing inhibitors target microbial β-glucuronidases linked to gut toxicity.
Authors: Graboski AL; Department of Pharmacology, University of North Carolina Chapel Hill North Carolina USA., Simpson JB; Department of Chemistry, University of North Carolina Chapel Hill North Carolina USA redinbo@unc.edu., Pellock SJ; Department of Chemistry, University of North Carolina Chapel Hill North Carolina USA redinbo@unc.edu., Mehta N; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina Chapel Hill North Carolina USA., Creekmore BC; Department of Chemistry, University of North Carolina Chapel Hill North Carolina USA redinbo@unc.edu., Ariyarathna Y; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina Chapel Hill North Carolina USA., Bhatt AP; Division of Gastroenterology and Hepatology, Department of Medicine, Center for Gastrointestinal Biology and Disease, and the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill Chapel Hill NC USA., Jariwala PB; Department of Chemistry, University of North Carolina Chapel Hill North Carolina USA redinbo@unc.edu., Sekela JJ; Department of Chemistry, University of North Carolina Chapel Hill North Carolina USA redinbo@unc.edu., Kowalewski ME; Department of Biochemistry and Biophysics, University of North Carolina Chapel Hill North Carolina USA., Barker NK; UNC Proteomics Core Facility, Department of Pharmacology, University of North Carolina at Chapel Hill Chapel Hill NC USA., Mordant AL; UNC Proteomics Core Facility, Department of Pharmacology, University of North Carolina at Chapel Hill Chapel Hill NC USA., Borlandelli VB; Department of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University Leiden The Netherlands., Overkleeft H; Department of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University Leiden The Netherlands., Herring LE; UNC Proteomics Core Facility, Department of Pharmacology, University of North Carolina at Chapel Hill Chapel Hill NC USA., Jin J; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai New York NY USA., I James L; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina Chapel Hill North Carolina USA., Redinbo MR; Department of Chemistry, University of North Carolina Chapel Hill North Carolina USA redinbo@unc.edu.; Department of Biochemistry and Biophysics, University of North Carolina Chapel Hill North Carolina USA.
Source: RSC chemical biology [RSC Chem Biol] 2024 Jul 16; Vol. 5 (9), pp. 853-865. Date of Electronic Publication: 2024 Jul 16 (Print Publication: 2024).
Publication Type: Journal Article
Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101768727 Publication Model: eCollection Cited Medium: Internet ISSN: 2633-0679 (Electronic) Linking ISSN: 26330679 NLM ISO Abbreviation: RSC Chem Biol Subsets: PubMed not MEDLINE
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  Data: Advanced piperazine-containing inhibitors target microbial β-glucuronidases linked to gut toxicity.
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  Data: <searchLink fieldCode="AU" term="%22Graboski+AL%22">Graboski AL</searchLink>; Department of Pharmacology, University of North Carolina Chapel Hill North Carolina USA.<br /><searchLink fieldCode="AU" term="%22Simpson+JB%22">Simpson JB</searchLink>; Department of Chemistry, University of North Carolina Chapel Hill North Carolina USA redinbo@unc.edu.<br /><searchLink fieldCode="AU" term="%22Pellock+SJ%22">Pellock SJ</searchLink>; Department of Chemistry, University of North Carolina Chapel Hill North Carolina USA redinbo@unc.edu.<br /><searchLink fieldCode="AU" term="%22Mehta+N%22">Mehta N</searchLink>; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina Chapel Hill North Carolina USA.<br /><searchLink fieldCode="AU" term="%22Creekmore+BC%22">Creekmore BC</searchLink>; Department of Chemistry, University of North Carolina Chapel Hill North Carolina USA redinbo@unc.edu.<br /><searchLink fieldCode="AU" term="%22Ariyarathna+Y%22">Ariyarathna Y</searchLink>; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina Chapel Hill North Carolina USA.<br /><searchLink fieldCode="AU" term="%22Bhatt+AP%22">Bhatt AP</searchLink>; Division of Gastroenterology and Hepatology, Department of Medicine, Center for Gastrointestinal Biology and Disease, and the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill Chapel Hill NC USA.<br /><searchLink fieldCode="AU" term="%22Jariwala+PB%22">Jariwala PB</searchLink>; Department of Chemistry, University of North Carolina Chapel Hill North Carolina USA redinbo@unc.edu.<br /><searchLink fieldCode="AU" term="%22Sekela+JJ%22">Sekela JJ</searchLink>; Department of Chemistry, University of North Carolina Chapel Hill North Carolina USA redinbo@unc.edu.<br /><searchLink fieldCode="AU" term="%22Kowalewski+ME%22">Kowalewski ME</searchLink>; Department of Biochemistry and Biophysics, University of North Carolina Chapel Hill North Carolina USA.<br /><searchLink fieldCode="AU" term="%22Barker+NK%22">Barker NK</searchLink>; UNC Proteomics Core Facility, Department of Pharmacology, University of North Carolina at Chapel Hill Chapel Hill NC USA.<br /><searchLink fieldCode="AU" term="%22Mordant+AL%22">Mordant AL</searchLink>; UNC Proteomics Core Facility, Department of Pharmacology, University of North Carolina at Chapel Hill Chapel Hill NC USA.<br /><searchLink fieldCode="AU" term="%22Borlandelli+VB%22">Borlandelli VB</searchLink>; Department of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University Leiden The Netherlands.<br /><searchLink fieldCode="AU" term="%22Overkleeft+H%22">Overkleeft H</searchLink>; Department of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University Leiden The Netherlands.<br /><searchLink fieldCode="AU" term="%22Herring+LE%22">Herring LE</searchLink>; UNC Proteomics Core Facility, Department of Pharmacology, University of North Carolina at Chapel Hill Chapel Hill NC USA.<br /><searchLink fieldCode="AU" term="%22Jin+J%22">Jin J</searchLink>; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai New York NY USA.<br /><searchLink fieldCode="AU" term="%22I+James+L%22">I James L</searchLink>; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina Chapel Hill North Carolina USA.<br /><searchLink fieldCode="AU" term="%22Redinbo+MR%22">Redinbo MR</searchLink>; Department of Chemistry, University of North Carolina Chapel Hill North Carolina USA redinbo@unc.edu.; Department of Biochemistry and Biophysics, University of North Carolina Chapel Hill North Carolina USA.
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