How to develop a controlled human infection model for Clostridioides difficile.

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Title: How to develop a controlled human infection model for Clostridioides difficile.
Authors: Hensen ADO; Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center (LUMC), Leiden, The Netherlands., Vehreschild MJGT; Department of Internal Medicine, Division of Infectious Diseases, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany; German Center for Infection Research (DZIF), Cologne, Germany., Gerding DN; Department of Veterans Affairs, Edward Hines Jr VA Hospital, Hines, IL, United States., Krut O; Paul-Ehrlich-Institut (PEI), Langen, Germany., Chen W; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, United States., Young VB; Department of Internal Medicine/Infectious Diseases Division and the Department of Microbiology & Immunology, The University of Michigan, Ann Arbor, MI, United States., Tzipori S; Division of Infectious Disease and Global Health, Tufts University, Medford, MA, United States., Solbach P; First Department of Medicine, University Medical Center Schleswig-Holstein, Kiel, Germany., Gibani MM; Department of Infectious Disease, Imperial College London (ICL), London, United Kingdom., Chiu C; Department of Infectious Disease, Imperial College London (ICL), London, United Kingdom., de Keersmaecker SCJ; Transversal Activities in Applied Genomics, Sciensano, Brussels, Belgium., Dasyam D; GSK, Rixensart, Belgium., Morel S; GSK, Rixensart, Belgium., Devaster JM; GSK, Rixensart, Belgium., Corti N; European Vaccine Initiative (EVI), Heidelberg, Germany., Kuijper EJ; Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center (LUMC), Leiden, The Netherlands., Roestenberg M; Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center (LUMC), Leiden, The Netherlands. Electronic address: m.roestenberg@lumc.nl., Smits WK; Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center (LUMC), Leiden, The Netherlands.
Source: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases [Clin Microbiol Infect] 2025 Mar; Vol. 31 (3), pp. 373-379. Date of Electronic Publication: 2024 Aug 29.
Publication Type: Journal Article; Review
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 9516420 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-0691 (Electronic) Linking ISSN: 1198743X NLM ISO Abbreviation: Clin Microbiol Infect Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: How to develop a controlled human infection model for Clostridioides difficile.
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  Data: <searchLink fieldCode="AU" term="%22Hensen+ADO%22">Hensen ADO</searchLink>; Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center (LUMC), Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Vehreschild+MJGT%22">Vehreschild MJGT</searchLink>; Department of Internal Medicine, Division of Infectious Diseases, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany; German Center for Infection Research (DZIF), Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Gerding+DN%22">Gerding DN</searchLink>; Department of Veterans Affairs, Edward Hines Jr VA Hospital, Hines, IL, United States.<br /><searchLink fieldCode="AU" term="%22Krut+O%22">Krut O</searchLink>; Paul-Ehrlich-Institut (PEI), Langen, Germany.<br /><searchLink fieldCode="AU" term="%22Chen+W%22">Chen W</searchLink>; Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, United States.<br /><searchLink fieldCode="AU" term="%22Young+VB%22">Young VB</searchLink>; Department of Internal Medicine/Infectious Diseases Division and the Department of Microbiology & Immunology, The University of Michigan, Ann Arbor, MI, United States.<br /><searchLink fieldCode="AU" term="%22Tzipori+S%22">Tzipori S</searchLink>; Division of Infectious Disease and Global Health, Tufts University, Medford, MA, United States.<br /><searchLink fieldCode="AU" term="%22Solbach+P%22">Solbach P</searchLink>; First Department of Medicine, University Medical Center Schleswig-Holstein, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Gibani+MM%22">Gibani MM</searchLink>; Department of Infectious Disease, Imperial College London (ICL), London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Chiu+C%22">Chiu C</searchLink>; Department of Infectious Disease, Imperial College London (ICL), London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22de+Keersmaecker+SCJ%22">de Keersmaecker SCJ</searchLink>; Transversal Activities in Applied Genomics, Sciensano, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Dasyam+D%22">Dasyam D</searchLink>; GSK, Rixensart, Belgium.<br /><searchLink fieldCode="AU" term="%22Morel+S%22">Morel S</searchLink>; GSK, Rixensart, Belgium.<br /><searchLink fieldCode="AU" term="%22Devaster+JM%22">Devaster JM</searchLink>; GSK, Rixensart, Belgium.<br /><searchLink fieldCode="AU" term="%22Corti+N%22">Corti N</searchLink>; European Vaccine Initiative (EVI), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Kuijper+EJ%22">Kuijper EJ</searchLink>; Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center (LUMC), Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Roestenberg+M%22">Roestenberg M</searchLink>; Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center (LUMC), Leiden, The Netherlands. Electronic address: m.roestenberg@lumc.nl.<br /><searchLink fieldCode="AU" term="%22Smits+WK%22">Smits WK</searchLink>; Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center (LUMC), Leiden, The Netherlands.
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  Data: <searchLink fieldCode="JN" term="%229516420%22">Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases</searchLink> [Clin Microbiol Infect] 2025 Mar; Vol. 31 (3), pp. 373-379. <i>Date of Electronic Publication: </i>2024 Aug 29.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9516420 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1469-0691 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221198743X%22">1198743X </searchLink><i>NLM ISO Abbreviation: </i>Clin Microbiol Infect <i>Subsets: </i>MEDLINE
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