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Metavert synergises with standard cytotoxics in human PDAC organoids and is associated with transcriptomic signatures of therapeutic response.

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Title: Metavert synergises with standard cytotoxics in human PDAC organoids and is associated with transcriptomic signatures of therapeutic response.
Authors: An J; Heidelberg University Hospital, Department of General, Visceral and Transplantation Surgery, Im Neuenheimer Feld 420, Heidelberg 69120, Germany., Kurilov R; Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), Berliner Str. 41, Heidelberg 69120, Germany., Peccerella T; Heidelberg University Hospital, Department of General, Visceral and Transplantation Surgery, Im Neuenheimer Feld 420, Heidelberg 69120, Germany., Bergmann F; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany., Edderkaoui M; Department of Medicine, Cedars-Sinai Medical Center and University of California at Los Angeles, Thalians W204 8700 Beverly Blvd. Los Angeles, California CA 90048, United States., Lim A; Department of Medicine, Cedars-Sinai Medical Center and University of California at Los Angeles, Thalians W204 8700 Beverly Blvd. Los Angeles, California CA 90048, United States., Zhou X; Heidelberg University Hospital, Department of General, Visceral and Transplantation Surgery, Im Neuenheimer Feld 420, Heidelberg 69120, Germany., Pfütze K; Sample Processing Laboratory, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, Germany., Schulz A; NGS Core Facility, The German Cancer Research Center (DKFZ), Heidelberg, Germany., Wolf S; NGS Core Facility, The German Cancer Research Center (DKFZ), Heidelberg, Germany., Hu K; Heidelberg University Hospital, Department of General, Visceral and Transplantation Surgery, Im Neuenheimer Feld 420, Heidelberg 69120, Germany., Springfeld C; Department of Medical Oncology, National Center for Tumor Diseases, University Clinic Heidelberg, Heidelberg 69120, Germany., Mughal SS; Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), Berliner Str. 41, Heidelberg 69120, Germany., Zezlina L; Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), Berliner Str. 41, Heidelberg 69120, Germany., Fortunato F; Heidelberg University Hospital, Department of General, Visceral and Transplantation Surgery, Im Neuenheimer Feld 420, Heidelberg 69120, Germany., Beyer G; Department of Internal Medicine II, Ludwig-Maximilians-University of Munich, Germany., Mayerle J; Department of Internal Medicine II, Ludwig-Maximilians-University of Munich, Germany., Roth S; Heidelberg University Hospital, Department of General, Visceral and Transplantation Surgery, Im Neuenheimer Feld 420, Heidelberg 69120, Germany., Hulkkonen J; Heidelberg University Hospital, Department of General, Visceral and Transplantation Surgery, Im Neuenheimer Feld 420, Heidelberg 69120, Germany., Merz D; Heidelberg University Hospital, Department of General, Visceral and Transplantation Surgery, Im Neuenheimer Feld 420, Heidelberg 69120, Germany., Ei S; Department of Gastroenterological Surgery, Tokai University School of Medicine, Kanagawa, Japan., Mehrabi A; Heidelberg University Hospital, Department of General, Visceral and Transplantation Surgery, Im Neuenheimer Feld 420, Heidelberg 69120, Germany., Loos M; Heidelberg University Hospital, Department of General, Visceral and Transplantation Surgery, Im Neuenheimer Feld 420, Heidelberg 69120, Germany., Al-Saeedi M; Heidelberg University Hospital, Department of General, Visceral and Transplantation Surgery, Im Neuenheimer Feld 420, Heidelberg 69120, Germany., Michalski CW; Heidelberg University Hospital, Department of General, Visceral and Transplantation Surgery, Im Neuenheimer Feld 420, Heidelberg 69120, Germany., Büchler MW; Heidelberg University Hospital, Department of General, Visceral and Transplantation Surgery, Im Neuenheimer Feld 420, Heidelberg 69120, Germany; Botton-Champalimaud Pancreatic Cancer Centre, Lisbon, Portugal., Hackert T; Heidelberg University Hospital, Department of General, Visceral and Transplantation Surgery, Im Neuenheimer Feld 420, Heidelberg 69120, Germany; Department of General, Visceral and Thoracic Surgery, University Hospital Hamburg-Eppendorf, Hamburg, Germany., Brors B; Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), Berliner Str. 41, Heidelberg 69120, Germany; German Cancer Consortium (DKTK), Core Center Heidelberg, Im Neuenheimer Feld 280, Heidelberg 69120, Germany; Medical Faculty and Faculty of Biosciences, Heidelberg University, Im Neuenheimer Feld 234, Heidelberg 69120, Germany; National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 460, Heidelberg 69120, Germany., Pandol SJ; Department of Medicine, Cedars-Sinai Medical Center and University of California at Los Angeles, Thalians W204 8700 Beverly Blvd. Los Angeles, California CA 90048, United States., Bailey P; Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), Berliner Str. 41, Heidelberg 69120, Germany; Botton-Champalimaud Pancreatic Cancer Centre, Lisbon, Portugal. Electronic address: peter.bailey@research.fchampalimaud.org., Neoptolemos JP; Heidelberg University Hospital, Department of General, Visceral and Transplantation Surgery, Im Neuenheimer Feld 420, Heidelberg 69120, Germany; Botton-Champalimaud Pancreatic Cancer Centre, Lisbon, Portugal. Electronic address: john.neoptolemos@med.uni-heidelberg.de.
Source: Translational oncology [Transl Oncol] 2024 Nov; Vol. 49, pp. 102109. Date of Electronic Publication: 2024 Aug 31.
Publication Type: Journal Article
Journal Info: Publisher: Neoplasia Press Country of Publication: United States NLM ID: 101472619 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1936-5233 (Print) Linking ISSN: 19365233 NLM ISO Abbreviation: Transl Oncol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Metavert synergises with standard cytotoxics in human PDAC organoids and is associated with transcriptomic signatures of therapeutic response.
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  Data: <searchLink fieldCode="AU" term="%22An+J%22">An J</searchLink>; Heidelberg University Hospital, Department of General, Visceral and Transplantation Surgery, Im Neuenheimer Feld 420, Heidelberg 69120, Germany.<br /><searchLink fieldCode="AU" term="%22Kurilov+R%22">Kurilov R</searchLink>; Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), Berliner Str. 41, Heidelberg 69120, Germany.<br /><searchLink fieldCode="AU" term="%22Peccerella+T%22">Peccerella T</searchLink>; Heidelberg University Hospital, Department of General, Visceral and Transplantation Surgery, Im Neuenheimer Feld 420, Heidelberg 69120, Germany.<br /><searchLink fieldCode="AU" term="%22Bergmann+F%22">Bergmann F</searchLink>; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Edderkaoui+M%22">Edderkaoui M</searchLink>; Department of Medicine, Cedars-Sinai Medical Center and University of California at Los Angeles, Thalians W204 8700 Beverly Blvd. Los Angeles, California CA 90048, United States.<br /><searchLink fieldCode="AU" term="%22Lim+A%22">Lim A</searchLink>; Department of Medicine, Cedars-Sinai Medical Center and University of California at Los Angeles, Thalians W204 8700 Beverly Blvd. Los Angeles, California CA 90048, United States.<br /><searchLink fieldCode="AU" term="%22Zhou+X%22">Zhou X</searchLink>; Heidelberg University Hospital, Department of General, Visceral and Transplantation Surgery, Im Neuenheimer Feld 420, Heidelberg 69120, Germany.<br /><searchLink fieldCode="AU" term="%22Pfütze+K%22">Pfütze K</searchLink>; Sample Processing Laboratory, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Schulz+A%22">Schulz A</searchLink>; NGS Core Facility, The German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Wolf+S%22">Wolf S</searchLink>; NGS Core Facility, The German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hu+K%22">Hu K</searchLink>; Heidelberg University Hospital, Department of General, Visceral and Transplantation Surgery, Im Neuenheimer Feld 420, Heidelberg 69120, Germany.<br /><searchLink fieldCode="AU" term="%22Springfeld+C%22">Springfeld C</searchLink>; Department of Medical Oncology, National Center for Tumor Diseases, University Clinic Heidelberg, Heidelberg 69120, Germany.<br /><searchLink fieldCode="AU" term="%22Mughal+SS%22">Mughal SS</searchLink>; Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), Berliner Str. 41, Heidelberg 69120, Germany.<br /><searchLink fieldCode="AU" term="%22Zezlina+L%22">Zezlina L</searchLink>; Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), Berliner Str. 41, Heidelberg 69120, Germany.<br /><searchLink fieldCode="AU" term="%22Fortunato+F%22">Fortunato F</searchLink>; Heidelberg University Hospital, Department of General, Visceral and Transplantation Surgery, Im Neuenheimer Feld 420, Heidelberg 69120, Germany.<br /><searchLink fieldCode="AU" term="%22Beyer+G%22">Beyer G</searchLink>; Department of Internal Medicine II, Ludwig-Maximilians-University of Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Mayerle+J%22">Mayerle J</searchLink>; Department of Internal Medicine II, Ludwig-Maximilians-University of Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Roth+S%22">Roth S</searchLink>; Heidelberg University Hospital, Department of General, Visceral and Transplantation Surgery, Im Neuenheimer Feld 420, Heidelberg 69120, Germany.<br /><searchLink fieldCode="AU" term="%22Hulkkonen+J%22">Hulkkonen J</searchLink>; Heidelberg University Hospital, Department of General, Visceral and Transplantation Surgery, Im Neuenheimer Feld 420, Heidelberg 69120, Germany.<br /><searchLink fieldCode="AU" term="%22Merz+D%22">Merz D</searchLink>; Heidelberg University Hospital, Department of General, Visceral and Transplantation Surgery, Im Neuenheimer Feld 420, Heidelberg 69120, Germany.<br /><searchLink fieldCode="AU" term="%22Ei+S%22">Ei S</searchLink>; Department of Gastroenterological Surgery, Tokai University School of Medicine, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Mehrabi+A%22">Mehrabi A</searchLink>; Heidelberg University Hospital, Department of General, Visceral and Transplantation Surgery, Im Neuenheimer Feld 420, Heidelberg 69120, Germany.<br /><searchLink fieldCode="AU" term="%22Loos+M%22">Loos M</searchLink>; Heidelberg University Hospital, Department of General, Visceral and Transplantation Surgery, Im Neuenheimer Feld 420, Heidelberg 69120, Germany.<br /><searchLink fieldCode="AU" term="%22Al-Saeedi+M%22">Al-Saeedi M</searchLink>; Heidelberg University Hospital, Department of General, Visceral and Transplantation Surgery, Im Neuenheimer Feld 420, Heidelberg 69120, Germany.<br /><searchLink fieldCode="AU" term="%22Michalski+CW%22">Michalski CW</searchLink>; Heidelberg University Hospital, Department of General, Visceral and Transplantation Surgery, Im Neuenheimer Feld 420, Heidelberg 69120, Germany.<br /><searchLink fieldCode="AU" term="%22Büchler+MW%22">Büchler MW</searchLink>; Heidelberg University Hospital, Department of General, Visceral and Transplantation Surgery, Im Neuenheimer Feld 420, Heidelberg 69120, Germany; Botton-Champalimaud Pancreatic Cancer Centre, Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Hackert+T%22">Hackert T</searchLink>; Heidelberg University Hospital, Department of General, Visceral and Transplantation Surgery, Im Neuenheimer Feld 420, Heidelberg 69120, Germany; Department of General, Visceral and Thoracic Surgery, University Hospital Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Brors+B%22">Brors B</searchLink>; Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), Berliner Str. 41, Heidelberg 69120, Germany; German Cancer Consortium (DKTK), Core Center Heidelberg, Im Neuenheimer Feld 280, Heidelberg 69120, Germany; Medical Faculty and Faculty of Biosciences, Heidelberg University, Im Neuenheimer Feld 234, Heidelberg 69120, Germany; National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 460, Heidelberg 69120, Germany.<br /><searchLink fieldCode="AU" term="%22Pandol+SJ%22">Pandol SJ</searchLink>; Department of Medicine, Cedars-Sinai Medical Center and University of California at Los Angeles, Thalians W204 8700 Beverly Blvd. Los Angeles, California CA 90048, United States.<br /><searchLink fieldCode="AU" term="%22Bailey+P%22">Bailey P</searchLink>; Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), Berliner Str. 41, Heidelberg 69120, Germany; Botton-Champalimaud Pancreatic Cancer Centre, Lisbon, Portugal. Electronic address: peter.bailey@research.fchampalimaud.org.<br /><searchLink fieldCode="AU" term="%22Neoptolemos+JP%22">Neoptolemos JP</searchLink>; Heidelberg University Hospital, Department of General, Visceral and Transplantation Surgery, Im Neuenheimer Feld 420, Heidelberg 69120, Germany; Botton-Champalimaud Pancreatic Cancer Centre, Lisbon, Portugal. Electronic address: john.neoptolemos@med.uni-heidelberg.de.
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  Data: <searchLink fieldCode="JN" term="%22101472619%22">Translational oncology</searchLink> [Transl Oncol] 2024 Nov; Vol. 49, pp. 102109. <i>Date of Electronic Publication: </i>2024 Aug 31.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Neoplasia+Press%22">Neoplasia Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101472619 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>1936-5233 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219365233%22">19365233 </searchLink><i>NLM ISO Abbreviation: </i>Transl Oncol <i>Subsets: </i>PubMed not MEDLINE
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