Intensified versus standard dose infliximab induction therapy for steroid-refractory acute severe ulcerative colitis (PREDICT-UC): an open-label, multicentre, randomised controlled trial.

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Title: Intensified versus standard dose infliximab induction therapy for steroid-refractory acute severe ulcerative colitis (PREDICT-UC): an open-label, multicentre, randomised controlled trial.
Authors: Choy MC; Department of Gastroenterology, Austin Health, Melbourne, VIC, Australia; Department of Medicine (Austin Health), University of Melbourne, Melbourne, VIC, Australia., Li Wai Suen CFD; Department of Gastroenterology, Austin Health, Melbourne, VIC, Australia; Department of Medicine (Austin Health), University of Melbourne, Melbourne, VIC, Australia., Con D; Department of Gastroenterology, Austin Health, Melbourne, VIC, Australia; Department of Medicine (Austin Health), University of Melbourne, Melbourne, VIC, Australia., Boyd K; Department of Gastroenterology, Austin Health, Melbourne, VIC, Australia., Pena R; Department of Gastroenterology, Austin Health, Melbourne, VIC, Australia., Burrell K; Department of Gastroenterology, Austin Health, Melbourne, VIC, Australia., Rosella O; Department of Gastroenterology, Austin Health, Melbourne, VIC, Australia., Proud D; Department of Colorectal Surgery, Austin Health, Melbourne, VIC, Australia., Brouwer R; Department of Colorectal Surgery, Austin Health, Melbourne, VIC, Australia., Gorelik A; School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia., Liew D; Department of Medicine, University of Adelaide, Adelaide, SA, Australia., Connell WR; Department of Gastroenterology, St Vincent's Hospital, Melbourne, VIC, Australia., Wright EK; Department of Gastroenterology, St Vincent's Hospital, Melbourne, VIC, Australia., Taylor KM; Department of Gastroenterology, Alfred Health and Monash University, Melbourne, VIC, Australia., Pudipeddi A; Department of Gastroenterology Concord Repatriation General Hospital, Sydney, NSW, Australia., Sawers M; Department of Gastroenterology, Barwon Health, Geelong, VIC, Australia., Christensen B; Department of Gastroenterology, Royal Melbourne Hospital, Melbourne, VIC, Australia., Ng W; Department of Gastroenterology, Liverpool Hospital, Sydney, NSW, Australia., Begun J; Department of Gastroenterology, Mater Hospital, Brisbane, QLD, Australia., Radford-Smith G; Department of Gastroenterology, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia., Garg M; Department of Medicine, University of Melbourne, Melbourne, VIC, Australia; Department of Gastroenterology, Northern Health, Melbourne, VIC, Australia., Martin N; Department of Gastroenterology, Princess Alexandra Hospital, Brisbane, QLD, Australia., van Langenberg DR; Department of Gastroenterology, Eastern Health, Melbourne, VIC, Australia., Ding NS; Department of Gastroenterology, St Vincent's Hospital, Melbourne, VIC, Australia., Beswick L; Department of Gastroenterology, Barwon Health, Geelong, VIC, Australia., Leong RW; Department of Gastroenterology Concord Repatriation General Hospital, Sydney, NSW, Australia., Sparrow MP; Department of Gastroenterology, Alfred Health and Monash University, Melbourne, VIC, Australia., De Cruz P; Department of Gastroenterology, Austin Health, Melbourne, VIC, Australia; Department of Medicine (Austin Health), University of Melbourne, Melbourne, VIC, Australia. Electronic address: p.decruz@unimelb.edu.au.
Source: The lancet. Gastroenterology & hepatology [Lancet Gastroenterol Hepatol] 2024 Nov; Vol. 9 (11), pp. 981-996. Date of Electronic Publication: 2024 Sep 02.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study; Comparative Study; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101690683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2468-1253 (Electronic) NLM ISO Abbreviation: Lancet Gastroenterol Hepatol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Intensified versus standard dose infliximab induction therapy for steroid-refractory acute severe ulcerative colitis (PREDICT-UC): an open-label, multicentre, randomised controlled trial.
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  Data: <searchLink fieldCode="AU" term="%22Choy+MC%22">Choy MC</searchLink>; Department of Gastroenterology, Austin Health, Melbourne, VIC, Australia; Department of Medicine (Austin Health), University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Li+Wai+Suen+CFD%22">Li Wai Suen CFD</searchLink>; Department of Gastroenterology, Austin Health, Melbourne, VIC, Australia; Department of Medicine (Austin Health), University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Con+D%22">Con D</searchLink>; Department of Gastroenterology, Austin Health, Melbourne, VIC, Australia; Department of Medicine (Austin Health), University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Boyd+K%22">Boyd K</searchLink>; Department of Gastroenterology, Austin Health, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Pena+R%22">Pena R</searchLink>; Department of Gastroenterology, Austin Health, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Burrell+K%22">Burrell K</searchLink>; Department of Gastroenterology, Austin Health, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Rosella+O%22">Rosella O</searchLink>; Department of Gastroenterology, Austin Health, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Proud+D%22">Proud D</searchLink>; Department of Colorectal Surgery, Austin Health, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Brouwer+R%22">Brouwer R</searchLink>; Department of Colorectal Surgery, Austin Health, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Gorelik+A%22">Gorelik A</searchLink>; School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Liew+D%22">Liew D</searchLink>; Department of Medicine, University of Adelaide, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Connell+WR%22">Connell WR</searchLink>; Department of Gastroenterology, St Vincent's Hospital, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Wright+EK%22">Wright EK</searchLink>; Department of Gastroenterology, St Vincent's Hospital, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Taylor+KM%22">Taylor KM</searchLink>; Department of Gastroenterology, Alfred Health and Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Pudipeddi+A%22">Pudipeddi A</searchLink>; Department of Gastroenterology Concord Repatriation General Hospital, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Sawers+M%22">Sawers M</searchLink>; Department of Gastroenterology, Barwon Health, Geelong, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Christensen+B%22">Christensen B</searchLink>; Department of Gastroenterology, Royal Melbourne Hospital, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Ng+W%22">Ng W</searchLink>; Department of Gastroenterology, Liverpool Hospital, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Begun+J%22">Begun J</searchLink>; Department of Gastroenterology, Mater Hospital, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Radford-Smith+G%22">Radford-Smith G</searchLink>; Department of Gastroenterology, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Garg+M%22">Garg M</searchLink>; Department of Medicine, University of Melbourne, Melbourne, VIC, Australia; Department of Gastroenterology, Northern Health, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Martin+N%22">Martin N</searchLink>; Department of Gastroenterology, Princess Alexandra Hospital, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22van+Langenberg+DR%22">van Langenberg DR</searchLink>; Department of Gastroenterology, Eastern Health, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Ding+NS%22">Ding NS</searchLink>; Department of Gastroenterology, St Vincent's Hospital, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Beswick+L%22">Beswick L</searchLink>; Department of Gastroenterology, Barwon Health, Geelong, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Leong+RW%22">Leong RW</searchLink>; Department of Gastroenterology Concord Repatriation General Hospital, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Sparrow+MP%22">Sparrow MP</searchLink>; Department of Gastroenterology, Alfred Health and Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22De+Cruz+P%22">De Cruz P</searchLink>; Department of Gastroenterology, Austin Health, Melbourne, VIC, Australia; Department of Medicine (Austin Health), University of Melbourne, Melbourne, VIC, Australia. Electronic address: p.decruz@unimelb.edu.au.
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  Data: <searchLink fieldCode="JN" term="%22101690683%22">The lancet. Gastroenterology & hepatology</searchLink> [Lancet Gastroenterol Hepatol] 2024 Nov; Vol. 9 (11), pp. 981-996. <i>Date of Electronic Publication: </i>2024 Sep 02.
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