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PD-linked LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance via ERM hyperphosphorylation.

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Title: PD-linked LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance via ERM hyperphosphorylation.
Authors: Wang S; The Department of Cell Biology, Duke University Medical Center, Durham, NC, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD., Baumert R; The Department of Cell Biology, Duke University Medical Center, Durham, NC, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD., Séjourné G; The Department of Cell Biology, Duke University Medical Center, Durham, NC, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD., Bindu DS; The Department of Cell Biology, Duke University Medical Center, Durham, NC, USA.; Department of Neonatology, Children's Mercy Hospital, Kansas City, MO, USA., Dimond K; College of Psychology, Nova Southeastern University, Fort Lauderdale, FL, USA., Sakers K; The Department of Cell Biology, Duke University Medical Center, Durham, NC, USA.; Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC, USA., Vazquez L; The Department of Cell Biology, Duke University Medical Center, Durham, NC, USA.; The Department of Neurobiology, Duke University Medical Center, Durham, NC, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD., Moore JL; The Department of Cell Biology, Duke University Medical Center, Durham, NC, USA.; Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC, USA., Tan CX; Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA., Takano T; Division of Molecular Systems for Brain Function, Kyushu University Institute for Advanced Study, Medical Institute of Bioregulation, Japan.; Japan Science and Technology Agency, PRESTO, Japan., Rodriguez MP; The Department of Cell Biology, Duke University Medical Center, Durham, NC, USA., Brose N; The Department of Cell Biology, Duke University Medical Center, Durham, NC, USA., Bradley L; The Department of Cell Biology, Duke University Medical Center, Durham, NC, USA., Lessing R; The Department of Cell Biology, Duke University Medical Center, Durham, NC, USA., Soderling SH; The Department of Cell Biology, Duke University Medical Center, Durham, NC, USA.; The Department of Neurobiology, Duke University Medical Center, Durham, NC, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD., La Spada AR; The Department of Neurology, Duke University Medical Center, Durham, NC, USA.; Departments of Pathology & Laboratory Medicine, Neurology, Biological Chemistry, and Neurobiology & Behavior, University of California, Irvine, CA, USA.; UCI Center for Neurotherapeutics, University of California, Irvine, CA, USA., Eroglu C; The Department of Cell Biology, Duke University Medical Center, Durham, NC, USA.; The Department of Neurobiology, Duke University Medical Center, Durham, NC, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD.; Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Apr 25. Date of Electronic Publication: 2025 Apr 25.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: PD-linked LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance via ERM hyperphosphorylation.
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  Data: <searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; The Department of Cell Biology, Duke University Medical Center, Durham, NC, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD.<br /><searchLink fieldCode="AU" term="%22Baumert+R%22">Baumert R</searchLink>; The Department of Cell Biology, Duke University Medical Center, Durham, NC, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD.<br /><searchLink fieldCode="AU" term="%22Séjourné+G%22">Séjourné G</searchLink>; The Department of Cell Biology, Duke University Medical Center, Durham, NC, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD.<br /><searchLink fieldCode="AU" term="%22Bindu+DS%22">Bindu DS</searchLink>; The Department of Cell Biology, Duke University Medical Center, Durham, NC, USA.; Department of Neonatology, Children's Mercy Hospital, Kansas City, MO, USA.<br /><searchLink fieldCode="AU" term="%22Dimond+K%22">Dimond K</searchLink>; College of Psychology, Nova Southeastern University, Fort Lauderdale, FL, USA.<br /><searchLink fieldCode="AU" term="%22Sakers+K%22">Sakers K</searchLink>; The Department of Cell Biology, Duke University Medical Center, Durham, NC, USA.; Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Vazquez+L%22">Vazquez L</searchLink>; The Department of Cell Biology, Duke University Medical Center, Durham, NC, USA.; The Department of Neurobiology, Duke University Medical Center, Durham, NC, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD.<br /><searchLink fieldCode="AU" term="%22Moore+JL%22">Moore JL</searchLink>; The Department of Cell Biology, Duke University Medical Center, Durham, NC, USA.; Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Tan+CX%22">Tan CX</searchLink>; Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Takano+T%22">Takano T</searchLink>; Division of Molecular Systems for Brain Function, Kyushu University Institute for Advanced Study, Medical Institute of Bioregulation, Japan.; Japan Science and Technology Agency, PRESTO, Japan.<br /><searchLink fieldCode="AU" term="%22Rodriguez+MP%22">Rodriguez MP</searchLink>; The Department of Cell Biology, Duke University Medical Center, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Brose+N%22">Brose N</searchLink>; The Department of Cell Biology, Duke University Medical Center, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Bradley+L%22">Bradley L</searchLink>; The Department of Cell Biology, Duke University Medical Center, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Lessing+R%22">Lessing R</searchLink>; The Department of Cell Biology, Duke University Medical Center, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Soderling+SH%22">Soderling SH</searchLink>; The Department of Cell Biology, Duke University Medical Center, Durham, NC, USA.; The Department of Neurobiology, Duke University Medical Center, Durham, NC, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD.<br /><searchLink fieldCode="AU" term="%22La+Spada+AR%22">La Spada AR</searchLink>; The Department of Neurology, Duke University Medical Center, Durham, NC, USA.; Departments of Pathology & Laboratory Medicine, Neurology, Biological Chemistry, and Neurobiology & Behavior, University of California, Irvine, CA, USA.; UCI Center for Neurotherapeutics, University of California, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Eroglu+C%22">Eroglu C</searchLink>; The Department of Cell Biology, Duke University Medical Center, Durham, NC, USA.; The Department of Neurobiology, Duke University Medical Center, Durham, NC, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD.; Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC, USA.
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        Value: 10.1101/2023.04.09.536178
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