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Substrate interactions guide cyclase engineering and lasso peptide diversification.

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Title: Substrate interactions guide cyclase engineering and lasso peptide diversification.
Authors: Barrett SE; Department of Chemistry, University of Illinois Urbana-Champaign, Urbana, IL, USA.; Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA., Yin S; Department of Chemical and Biomolecular Engineering, University of Illinois Urbana-Champaign, Urbana, IL, USA., Jordan P; Lassogen, Inc., San Diego, CA, USA., Brunson JK; Lassogen, Inc., San Diego, CA, USA., Gordon-Nunez J; Lassogen, Inc., San Diego, CA, USA., Costa Machado da Cruz G; Lassogen, Inc., San Diego, CA, USA., Rosario C; Lassogen, Inc., San Diego, CA, USA., Okada BK; Lassogen, Inc., San Diego, CA, USA., Anderson K; Lassogen, Inc., San Diego, CA, USA., Pires TA; Department of Chemistry, University of Illinois Urbana-Champaign, Urbana, IL, USA.; Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA., Wang R; Department of Chemistry, University of Illinois Urbana-Champaign, Urbana, IL, USA.; Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA., Shukla D; Department of Chemistry, University of Illinois Urbana-Champaign, Urbana, IL, USA.; Department of Chemical and Biomolecular Engineering, University of Illinois Urbana-Champaign, Urbana, IL, USA.; Center for Biophysics and Quantitative Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA.; Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL, USA., Burk MJ; Lassogen, Inc., San Diego, CA, USA. mburk@lassogen.com., Mitchell DA; Department of Chemistry, University of Illinois Urbana-Champaign, Urbana, IL, USA. douglasm@illinois.edu.; Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA. douglasm@illinois.edu.; Department of Microbiology, University of Illinois Urbana-Champaign, Urbana, IL, USA. douglasm@illinois.edu.
Source: Nature chemical biology [Nat Chem Biol] 2025 Mar; Vol. 21 (3), pp. 412-419. Date of Electronic Publication: 2024 Sep 11.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Barrett+SE%22">Barrett SE</searchLink>; Department of Chemistry, University of Illinois Urbana-Champaign, Urbana, IL, USA.; Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA.<br /><searchLink fieldCode="AU" term="%22Yin+S%22">Yin S</searchLink>; Department of Chemical and Biomolecular Engineering, University of Illinois Urbana-Champaign, Urbana, IL, USA.<br /><searchLink fieldCode="AU" term="%22Jordan+P%22">Jordan P</searchLink>; Lassogen, Inc., San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Brunson+JK%22">Brunson JK</searchLink>; Lassogen, Inc., San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Gordon-Nunez+J%22">Gordon-Nunez J</searchLink>; Lassogen, Inc., San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Costa+Machado+da+Cruz+G%22">Costa Machado da Cruz G</searchLink>; Lassogen, Inc., San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rosario+C%22">Rosario C</searchLink>; Lassogen, Inc., San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Okada+BK%22">Okada BK</searchLink>; Lassogen, Inc., San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Anderson+K%22">Anderson K</searchLink>; Lassogen, Inc., San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Pires+TA%22">Pires TA</searchLink>; Department of Chemistry, University of Illinois Urbana-Champaign, Urbana, IL, USA.; Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA.<br /><searchLink fieldCode="AU" term="%22Wang+R%22">Wang R</searchLink>; Department of Chemistry, University of Illinois Urbana-Champaign, Urbana, IL, USA.; Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA.<br /><searchLink fieldCode="AU" term="%22Shukla+D%22">Shukla D</searchLink>; Department of Chemistry, University of Illinois Urbana-Champaign, Urbana, IL, USA.; Department of Chemical and Biomolecular Engineering, University of Illinois Urbana-Champaign, Urbana, IL, USA.; Center for Biophysics and Quantitative Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA.; Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL, USA.<br /><searchLink fieldCode="AU" term="%22Burk+MJ%22">Burk MJ</searchLink>; Lassogen, Inc., San Diego, CA, USA. mburk@lassogen.com.<br /><searchLink fieldCode="AU" term="%22Mitchell+DA%22">Mitchell DA</searchLink>; Department of Chemistry, University of Illinois Urbana-Champaign, Urbana, IL, USA. douglasm@illinois.edu.; Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA. douglasm@illinois.edu.; Department of Microbiology, University of Illinois Urbana-Champaign, Urbana, IL, USA. douglasm@illinois.edu.
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