In situ deposition of nanobodies by an engineered commensal microbe promotes survival in a mouse model of enterohemorrhagic E. coli.

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Title: In situ deposition of nanobodies by an engineered commensal microbe promotes survival in a mouse model of enterohemorrhagic E. coli.
Authors: Srivastava R; Center for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, MA 02115, USA.; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., González-Prieto C; Center for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, MA 02115, USA.; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Lynch JP; Center for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, MA 02115, USA.; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Muscolo ME; Center for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, MA 02115, USA., Lin CY; Center for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, MA 02115, USA., Brown MA; Center for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, MA 02115, USA.; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Lemos L; Center for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, MA 02115, USA.; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Shrestha A; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111, USA., Osburne MS; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111, USA., Leong JM; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111, USA.; Tufts Stuart B Levy Center for Integrated Management of Antimicrobial Resistance, Tufts University, Boston, MA 02111, USA., Lesser CF; Center for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, MA 02115, USA.; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Ragon Institute of Harvard and MIT, Cambridge, MA 02139, USA.
Source: PNAS nexus [PNAS Nexus] 2024 Sep 02; Vol. 3 (9), pp. pgae374. Date of Electronic Publication: 2024 Sep 02 (Print Publication: 2024).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press on behalf of the National Academy of Sciences Country of Publication: England NLM ID: 9918367777906676 Publication Model: eCollection Cited Medium: Internet ISSN: 2752-6542 (Electronic) Linking ISSN: 27526542 NLM ISO Abbreviation: PNAS Nexus Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2752-6542
DOI:10.1093/pnasnexus/pgae374