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In situ deposition of nanobodies by an engineered commensal microbe promotes survival in a mouse model of enterohemorrhagic E. coli.

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Title: In situ deposition of nanobodies by an engineered commensal microbe promotes survival in a mouse model of enterohemorrhagic E. coli.
Authors: Srivastava R; Center for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, MA 02115, USA.; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., González-Prieto C; Center for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, MA 02115, USA.; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Lynch JP; Center for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, MA 02115, USA.; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Muscolo ME; Center for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, MA 02115, USA., Lin CY; Center for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, MA 02115, USA., Brown MA; Center for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, MA 02115, USA.; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Lemos L; Center for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, MA 02115, USA.; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Shrestha A; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111, USA., Osburne MS; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111, USA., Leong JM; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111, USA.; Tufts Stuart B Levy Center for Integrated Management of Antimicrobial Resistance, Tufts University, Boston, MA 02111, USA., Lesser CF; Center for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, MA 02115, USA.; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Ragon Institute of Harvard and MIT, Cambridge, MA 02139, USA.
Source: PNAS nexus [PNAS Nexus] 2024 Sep 02; Vol. 3 (9), pp. pgae374. Date of Electronic Publication: 2024 Sep 02 (Print Publication: 2024).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press on behalf of the National Academy of Sciences Country of Publication: England NLM ID: 9918367777906676 Publication Model: eCollection Cited Medium: Internet ISSN: 2752-6542 (Electronic) Linking ISSN: 27526542 NLM ISO Abbreviation: PNAS Nexus Subsets: PubMed not MEDLINE
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  Data: In situ deposition of nanobodies by an engineered commensal microbe promotes survival in a mouse model of enterohemorrhagic E. coli.
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  Data: <searchLink fieldCode="AU" term="%22Srivastava+R%22">Srivastava R</searchLink>; Center for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, MA 02115, USA.; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22González-Prieto+C%22">González-Prieto C</searchLink>; Center for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, MA 02115, USA.; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Lynch+JP%22">Lynch JP</searchLink>; Center for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, MA 02115, USA.; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Muscolo+ME%22">Muscolo ME</searchLink>; Center for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Lin+CY%22">Lin CY</searchLink>; Center for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Brown+MA%22">Brown MA</searchLink>; Center for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, MA 02115, USA.; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Lemos+L%22">Lemos L</searchLink>; Center for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, MA 02115, USA.; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Shrestha+A%22">Shrestha A</searchLink>; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111, USA.<br /><searchLink fieldCode="AU" term="%22Osburne+MS%22">Osburne MS</searchLink>; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111, USA.<br /><searchLink fieldCode="AU" term="%22Leong+JM%22">Leong JM</searchLink>; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111, USA.; Tufts Stuart B Levy Center for Integrated Management of Antimicrobial Resistance, Tufts University, Boston, MA 02111, USA.<br /><searchLink fieldCode="AU" term="%22Lesser+CF%22">Lesser CF</searchLink>; Center for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, MA 02115, USA.; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Ragon Institute of Harvard and MIT, Cambridge, MA 02139, USA.
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  Data: <searchLink fieldCode="JN" term="%229918367777906676%22">PNAS nexus</searchLink> [PNAS Nexus] 2024 Sep 02; Vol. 3 (9), pp. pgae374. <i>Date of Electronic Publication: </i>2024 Sep 02 (<i>Print Publication: </i>2024).
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