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GDF-15 Predicts Epithelioid Hemangioendothelioma Aggressiveness and Is Downregulated by Sirolimus through ATF4/ATF5 Suppression.

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Title: GDF-15 Predicts Epithelioid Hemangioendothelioma Aggressiveness and Is Downregulated by Sirolimus through ATF4/ATF5 Suppression.
Authors: Stacchiotti S; Medical Oncology Unit 2, Cancer Medicine Department, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Nazionale Tumori, Milan, Italy., Martini S; Molecular Pharmacology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy., Pasquali S; Molecular Pharmacology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy., Frezza AM; Medical Oncology Unit 2, Cancer Medicine Department, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Nazionale Tumori, Milan, Italy., Beretta A; Molecular Pharmacology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy., Percio S; Molecular Pharmacology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy., Lecchi M; Unit of Bioinformatics and Biostatistics, Department Epidemiology and Data Science, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Tortoreto M; Molecular Pharmacology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy., Barisella M; Pathology Unit, ASST Fatebenefratelli Sacco, Milan, Italy., Collini P; Soft Tissue Tumor Pathology Unit, Department of Advanced Diagnostics, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy., Dagrada GP; Soft Tissue Tumor Pathology Unit, Department of Advanced Diagnostics, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy., Merlini A; Department of Oncology, University of Turin, Turin, Italy., Huang PH; Division of Molecular Pathology, Institute of Cancer Research, London, United Kingdom., Jenks A; Division of Molecular Pathology, Institute of Cancer Research, London, United Kingdom., Jones RL; The Institute of Cancer Research, London, United Kingdom.; The Royal Marsden NHS Foundation Trust, London, United Kingdom., Tap WD; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York., Ingrosso M; Medical Oncology Unit 2, Cancer Medicine Department, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Nazionale Tumori, Milan, Italy., Morosi C; Department of Radiology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy., Brich S; Soft Tissue Tumor Pathology Unit, Department of Advanced Diagnostics, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy., Giani C; Medical Oncology Unit 2, Cancer Medicine Department, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Nazionale Tumori, Milan, Italy., Verderio P; Unit of Bioinformatics and Biostatistics, Department Epidemiology and Data Science, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Casali PG; Medical Oncology Unit 2, Cancer Medicine Department, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Nazionale Tumori, Milan, Italy., Leonard H; Chair of Trustees of the EHE Rare Cancer Charity UK, Charity Number 1162472, Kingston-Upon-Thames, United Kingdom., Gronchi A; Sarcoma Service, Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy., Zuco V; Molecular Pharmacology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy., Zaffaroni N; Molecular Pharmacology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
Source: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2024 Nov 15; Vol. 30 (22), pp. 5122-5137.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE
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  Data: GDF-15 Predicts Epithelioid Hemangioendothelioma Aggressiveness and Is Downregulated by Sirolimus through ATF4/ATF5 Suppression.
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  Data: <searchLink fieldCode="AU" term="%22Stacchiotti+S%22">Stacchiotti S</searchLink>; Medical Oncology Unit 2, Cancer Medicine Department, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Nazionale Tumori, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Martini+S%22">Martini S</searchLink>; Molecular Pharmacology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Pasquali+S%22">Pasquali S</searchLink>; Molecular Pharmacology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Frezza+AM%22">Frezza AM</searchLink>; Medical Oncology Unit 2, Cancer Medicine Department, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Nazionale Tumori, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Beretta+A%22">Beretta A</searchLink>; Molecular Pharmacology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Percio+S%22">Percio S</searchLink>; Molecular Pharmacology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Lecchi+M%22">Lecchi M</searchLink>; Unit of Bioinformatics and Biostatistics, Department Epidemiology and Data Science, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Tortoreto+M%22">Tortoreto M</searchLink>; Molecular Pharmacology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Barisella+M%22">Barisella M</searchLink>; Pathology Unit, ASST Fatebenefratelli Sacco, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Collini+P%22">Collini P</searchLink>; Soft Tissue Tumor Pathology Unit, Department of Advanced Diagnostics, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Dagrada+GP%22">Dagrada GP</searchLink>; Soft Tissue Tumor Pathology Unit, Department of Advanced Diagnostics, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Merlini+A%22">Merlini A</searchLink>; Department of Oncology, University of Turin, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Huang+PH%22">Huang PH</searchLink>; Division of Molecular Pathology, Institute of Cancer Research, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Jenks+A%22">Jenks A</searchLink>; Division of Molecular Pathology, Institute of Cancer Research, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Jones+RL%22">Jones RL</searchLink>; The Institute of Cancer Research, London, United Kingdom.; The Royal Marsden NHS Foundation Trust, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Tap+WD%22">Tap WD</searchLink>; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Ingrosso+M%22">Ingrosso M</searchLink>; Medical Oncology Unit 2, Cancer Medicine Department, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Nazionale Tumori, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Morosi+C%22">Morosi C</searchLink>; Department of Radiology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Brich+S%22">Brich S</searchLink>; Soft Tissue Tumor Pathology Unit, Department of Advanced Diagnostics, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Giani+C%22">Giani C</searchLink>; Medical Oncology Unit 2, Cancer Medicine Department, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Nazionale Tumori, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Verderio+P%22">Verderio P</searchLink>; Unit of Bioinformatics and Biostatistics, Department Epidemiology and Data Science, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Casali+PG%22">Casali PG</searchLink>; Medical Oncology Unit 2, Cancer Medicine Department, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Nazionale Tumori, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Leonard+H%22">Leonard H</searchLink>; Chair of Trustees of the EHE Rare Cancer Charity UK, Charity Number 1162472, Kingston-Upon-Thames, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Gronchi+A%22">Gronchi A</searchLink>; Sarcoma Service, Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Zuco+V%22">Zuco V</searchLink>; Molecular Pharmacology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Zaffaroni+N%22">Zaffaroni N</searchLink>; Molecular Pharmacology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
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