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From whole-slide image to biomarker prediction: end-to-end weakly supervised deep learning in computational pathology.

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Title: From whole-slide image to biomarker prediction: end-to-end weakly supervised deep learning in computational pathology.
Authors: El Nahhas OSM; Else Kroener Fresenius Center for Digital Health, Medical Faculty Carl Gustav Carus, Technical University Dresden, Dresden, Germany.; StratifAI GmbH, Dresden, Germany., van Treeck M; Else Kroener Fresenius Center for Digital Health, Medical Faculty Carl Gustav Carus, Technical University Dresden, Dresden, Germany., Wölflein G; School of Computer Science, University of St Andrews, St Andrews, UK., Unger M; Else Kroener Fresenius Center for Digital Health, Medical Faculty Carl Gustav Carus, Technical University Dresden, Dresden, Germany., Ligero M; Else Kroener Fresenius Center for Digital Health, Medical Faculty Carl Gustav Carus, Technical University Dresden, Dresden, Germany., Lenz T; Else Kroener Fresenius Center for Digital Health, Medical Faculty Carl Gustav Carus, Technical University Dresden, Dresden, Germany., Wagner SJ; Helmholtz Munich-German Research Center for Environment and Health, Munich, Germany.; School of Computation, Information and Technology, Technical University of Munich, Munich, Germany., Hewitt KJ; Else Kroener Fresenius Center for Digital Health, Medical Faculty Carl Gustav Carus, Technical University Dresden, Dresden, Germany., Khader F; StratifAI GmbH, Dresden, Germany.; Department of Diagnostic and Interventional Radiology, University Hospital Aachen, Aachen, Germany., Foersch S; Institute of Pathology-University Medical Center Mainz, Mainz, Germany., Truhn D; StratifAI GmbH, Dresden, Germany.; Department of Diagnostic and Interventional Radiology, University Hospital Aachen, Aachen, Germany., Kather JN; Else Kroener Fresenius Center for Digital Health, Medical Faculty Carl Gustav Carus, Technical University Dresden, Dresden, Germany. jakob_nikolas.kather@tu-dresden.de.; StratifAI GmbH, Dresden, Germany. jakob_nikolas.kather@tu-dresden.de.; Medical Oncology, National Center for Tumor Diseases (NCT), University Hospital Heidelberg, Heidelberg, Germany. jakob_nikolas.kather@tu-dresden.de.; Department of Medicine 1, University Hospital and Faculty of Medicine Carl Gustav Carus, Technical University Dresden, Dresden, Germany. jakob_nikolas.kather@tu-dresden.de.
Source: Nature protocols [Nat Protoc] 2025 Jan; Vol. 20 (1), pp. 293-316. Date of Electronic Publication: 2024 Sep 16.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101284307 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1750-2799 (Electronic) Linking ISSN: 17502799 NLM ISO Abbreviation: Nat Protoc Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22El+Nahhas+OSM%22">El Nahhas OSM</searchLink>; Else Kroener Fresenius Center for Digital Health, Medical Faculty Carl Gustav Carus, Technical University Dresden, Dresden, Germany.; StratifAI GmbH, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22van+Treeck+M%22">van Treeck M</searchLink>; Else Kroener Fresenius Center for Digital Health, Medical Faculty Carl Gustav Carus, Technical University Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Wölflein+G%22">Wölflein G</searchLink>; School of Computer Science, University of St Andrews, St Andrews, UK.<br /><searchLink fieldCode="AU" term="%22Unger+M%22">Unger M</searchLink>; Else Kroener Fresenius Center for Digital Health, Medical Faculty Carl Gustav Carus, Technical University Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Ligero+M%22">Ligero M</searchLink>; Else Kroener Fresenius Center for Digital Health, Medical Faculty Carl Gustav Carus, Technical University Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Lenz+T%22">Lenz T</searchLink>; Else Kroener Fresenius Center for Digital Health, Medical Faculty Carl Gustav Carus, Technical University Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Wagner+SJ%22">Wagner SJ</searchLink>; Helmholtz Munich-German Research Center for Environment and Health, Munich, Germany.; School of Computation, Information and Technology, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Hewitt+KJ%22">Hewitt KJ</searchLink>; Else Kroener Fresenius Center for Digital Health, Medical Faculty Carl Gustav Carus, Technical University Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Khader+F%22">Khader F</searchLink>; StratifAI GmbH, Dresden, Germany.; Department of Diagnostic and Interventional Radiology, University Hospital Aachen, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Foersch+S%22">Foersch S</searchLink>; Institute of Pathology-University Medical Center Mainz, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Truhn+D%22">Truhn D</searchLink>; StratifAI GmbH, Dresden, Germany.; Department of Diagnostic and Interventional Radiology, University Hospital Aachen, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Kather+JN%22">Kather JN</searchLink>; Else Kroener Fresenius Center for Digital Health, Medical Faculty Carl Gustav Carus, Technical University Dresden, Dresden, Germany. jakob_nikolas.kather@tu-dresden.de.; StratifAI GmbH, Dresden, Germany. jakob_nikolas.kather@tu-dresden.de.; Medical Oncology, National Center for Tumor Diseases (NCT), University Hospital Heidelberg, Heidelberg, Germany. jakob_nikolas.kather@tu-dresden.de.; Department of Medicine 1, University Hospital and Faculty of Medicine Carl Gustav Carus, Technical University Dresden, Dresden, Germany. jakob_nikolas.kather@tu-dresden.de.
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