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DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response.

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Title: DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response.
Authors: Yulyaningsih E; Denali Therapeutics, South San Francisco, United States., Suh JH; Denali Therapeutics, South San Francisco, United States., Fanok M; Denali Therapeutics, South San Francisco, United States., Chau R; Denali Therapeutics, South San Francisco, United States., Solanoy H; Denali Therapeutics, South San Francisco, United States., Takahashi R; Denali Therapeutics, South San Francisco, United States., Bakardjiev AI; Denali Therapeutics, South San Francisco, United States., Becerra I; Denali Therapeutics, South San Francisco, United States., Benitez NB; Denali Therapeutics, South San Francisco, United States., Chiu CL; Denali Therapeutics, South San Francisco, United States., Davis SS; Denali Therapeutics, South San Francisco, United States., Dowdle WE; Denali Therapeutics, South San Francisco, United States., Earr T; Denali Therapeutics, South San Francisco, United States., Estrada AA; Denali Therapeutics, South San Francisco, United States., Gill A; Denali Therapeutics, South San Francisco, United States., Ha C; Denali Therapeutics, South San Francisco, United States., Haddick PCG; Denali Therapeutics, South San Francisco, United States., Henne KR; Denali Therapeutics, South San Francisco, United States., Larhammar M; Denali Therapeutics, South San Francisco, United States., Leung AW; Denali Therapeutics, South San Francisco, United States., Maciuca R; Denali Therapeutics, South San Francisco, United States., Memarzadeh B; Denali Therapeutics, South San Francisco, United States., Nguyen HN; Denali Therapeutics, South San Francisco, United States., Nugent AA; Denali Therapeutics, South San Francisco, United States., Osipov M; Denali Therapeutics, South San Francisco, United States., Ran Y; Denali Therapeutics, South San Francisco, United States., Rebadulla K; Denali Therapeutics, South San Francisco, United States., Roche E; Denali Therapeutics, South San Francisco, United States., Sandmann T; Denali Therapeutics, South San Francisco, United States., Wang J; Denali Therapeutics, South San Francisco, United States., Lewcock JW; Denali Therapeutics, South San Francisco, United States., Scearce-Levie K; Denali Therapeutics, South San Francisco, United States., Kane LA; Denali Therapeutics, South San Francisco, United States., Sanchez PE; Denali Therapeutics, South San Francisco, United States.
Source: ELife [Elife] 2024 Sep 17; Vol. 12. Date of Electronic Publication: 2024 Sep 17.
Publication Type: Journal Article
Journal Info: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response.
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  Data: <searchLink fieldCode="AU" term="%22Yulyaningsih+E%22">Yulyaningsih E</searchLink>; Denali Therapeutics, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Suh+JH%22">Suh JH</searchLink>; Denali Therapeutics, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Fanok+M%22">Fanok M</searchLink>; Denali Therapeutics, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Chau+R%22">Chau R</searchLink>; Denali Therapeutics, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Solanoy+H%22">Solanoy H</searchLink>; Denali Therapeutics, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Takahashi+R%22">Takahashi R</searchLink>; Denali Therapeutics, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Bakardjiev+AI%22">Bakardjiev AI</searchLink>; Denali Therapeutics, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Becerra+I%22">Becerra I</searchLink>; Denali Therapeutics, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Benitez+NB%22">Benitez NB</searchLink>; Denali Therapeutics, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Chiu+CL%22">Chiu CL</searchLink>; Denali Therapeutics, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Davis+SS%22">Davis SS</searchLink>; Denali Therapeutics, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Dowdle+WE%22">Dowdle WE</searchLink>; Denali Therapeutics, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Earr+T%22">Earr T</searchLink>; Denali Therapeutics, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Estrada+AA%22">Estrada AA</searchLink>; Denali Therapeutics, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Gill+A%22">Gill A</searchLink>; Denali Therapeutics, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Ha+C%22">Ha C</searchLink>; Denali Therapeutics, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Haddick+PCG%22">Haddick PCG</searchLink>; Denali Therapeutics, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Henne+KR%22">Henne KR</searchLink>; Denali Therapeutics, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Larhammar+M%22">Larhammar M</searchLink>; Denali Therapeutics, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Leung+AW%22">Leung AW</searchLink>; Denali Therapeutics, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Maciuca+R%22">Maciuca R</searchLink>; Denali Therapeutics, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Memarzadeh+B%22">Memarzadeh B</searchLink>; Denali Therapeutics, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Nguyen+HN%22">Nguyen HN</searchLink>; Denali Therapeutics, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Nugent+AA%22">Nugent AA</searchLink>; Denali Therapeutics, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Osipov+M%22">Osipov M</searchLink>; Denali Therapeutics, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Ran+Y%22">Ran Y</searchLink>; Denali Therapeutics, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Rebadulla+K%22">Rebadulla K</searchLink>; Denali Therapeutics, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Roche+E%22">Roche E</searchLink>; Denali Therapeutics, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Sandmann+T%22">Sandmann T</searchLink>; Denali Therapeutics, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Denali Therapeutics, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Lewcock+JW%22">Lewcock JW</searchLink>; Denali Therapeutics, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Scearce-Levie+K%22">Scearce-Levie K</searchLink>; Denali Therapeutics, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Kane+LA%22">Kane LA</searchLink>; Denali Therapeutics, South San Francisco, United States.<br /><searchLink fieldCode="AU" term="%22Sanchez+PE%22">Sanchez PE</searchLink>; Denali Therapeutics, South San Francisco, United States.
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        Value: 10.7554/eLife.92173
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