Phase I PIANO trial-PIPAC-oxaliplatin and systemic nivolumab combination for gastric cancer peritoneal metastases: clinical and translational outcomes.

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Title: Phase I PIANO trial-PIPAC-oxaliplatin and systemic nivolumab combination for gastric cancer peritoneal metastases: clinical and translational outcomes.
Authors: Sundar R; Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Haematology-Oncology, National University Cancer Institute, Singapore; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore; The N.1 Institute for Health, National University of Singapore, Singapore; Singapore Gastric Cancer Consortium, Singapore. Electronic address: mdcragh@nus.edu.sg., Chia DKA; Division of Upper Gastrointestinal Surgery, Department of Surgery, National University Hospital, National University Health System, Singapore., Zhao JJ; Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Haematology-Oncology, National University Cancer Institute, Singapore; Department of Medicine, National University Hospital, Singapore, Singapore., Lee ARYB; Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Kim G; Division of Upper Gastrointestinal Surgery, Department of Surgery, National University Hospital, National University Health System, Singapore., Tan HL; Department of Haematology-Oncology, National University Cancer Institute, Singapore., Pang A; Division of Upper Gastrointestinal Surgery, Department of Surgery, National University Hospital, National University Health System, Singapore., Shabbir A; Division of Upper Gastrointestinal Surgery, Department of Surgery, National University Hospital, National University Health System, Singapore., Willaert W; Department of Gastrointestinal Surgery, Ghent University Hospital, Ghent, Belgium., Ma H; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Huang KK; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Hagihara T; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Tan ALK; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Ong CJ; Singapore Gastric Cancer Consortium, Singapore; Department of Sarcoma, Peritoneal and Rare Tumors (SPRinT), Division of Surgery and Surgical Oncology, National Cancer Centre Singapore, Singapore, Singapore., Wong JSM; Department of Sarcoma, Peritoneal and Rare Tumors (SPRinT), Division of Surgery and Surgical Oncology, National Cancer Centre Singapore, Singapore, Singapore., Seo CJ; Department of Sarcoma, Peritoneal and Rare Tumors (SPRinT), Division of Surgery and Surgical Oncology, National Cancer Centre Singapore, Singapore, Singapore., Walsh R; Department of Haematology-Oncology, National University Cancer Institute, Singapore., Chan G; Department of Haematology-Oncology, National University Cancer Institute, Singapore., Cheo SW; Department of Haematology-Oncology, National University Cancer Institute, Singapore., Soh CCC; Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Callebout E; Department of Digestive Oncology, Gastroenterology, Ghent University Hospital, Ghent, Belgium., Geboes K; Department of Gastrointestinal Surgery, Ghent University Hospital, Ghent, Belgium., Ng MCH; Division of Medical Oncology, National Cancer Centre, Singapore; Duke NUS Medical School, Singapore., Lum JHY; Department of Pathology, National University Hospital, Singapore., Leow WQ; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore., Selvarajan S; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore., Hoorens A; Department of Pathology, Ghent University Hospital, Ghent, Belgium., Ang WH; Department of Chemistry, National University of Singapore, Singapore., Pang H; Department of Chemistry, National University of Singapore, Singapore., Tan P; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore; Singapore Gastric Cancer Consortium, Singapore., Yong WP; Department of Haematology-Oncology, National University Cancer Institute, Singapore; Singapore Gastric Cancer Consortium, Singapore., Chia CSL; Department of Sarcoma, Peritoneal and Rare Tumors (SPRinT), Division of Surgery and Surgical Oncology, National Cancer Centre Singapore, Singapore, Singapore., Ceelen W; Department of Gastrointestinal Surgery, Ghent University Hospital, Ghent, Belgium., So JBY; Singapore Gastric Cancer Consortium, Singapore; Division of Upper Gastrointestinal Surgery, Department of Surgery, National University Hospital, National University Health System, Singapore; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Division of Surgical Oncology, National University Cancer Institute of Singapore (NCIS), Singapore, Singapore. Electronic address: sursbyj@nus.edu.sg.
Source: ESMO open [ESMO Open] 2024 Sep; Vol. 9 (9), pp. 103681. Date of Electronic Publication: 2024 Sep 16.
Publication Type: Journal Article; Clinical Trial, Phase I; Multicenter Study
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101690685 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2059-7029 (Electronic) Linking ISSN: 20597029 NLM ISO Abbreviation: ESMO Open Subsets: MEDLINE
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  Data: Phase I PIANO trial-PIPAC-oxaliplatin and systemic nivolumab combination for gastric cancer peritoneal metastases: clinical and translational outcomes.
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  Data: <searchLink fieldCode="AU" term="%22Sundar+R%22">Sundar R</searchLink>; Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Haematology-Oncology, National University Cancer Institute, Singapore; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore; The N.1 Institute for Health, National University of Singapore, Singapore; Singapore Gastric Cancer Consortium, Singapore. Electronic address: mdcragh@nus.edu.sg.<br /><searchLink fieldCode="AU" term="%22Chia+DKA%22">Chia DKA</searchLink>; Division of Upper Gastrointestinal Surgery, Department of Surgery, National University Hospital, National University Health System, Singapore.<br /><searchLink fieldCode="AU" term="%22Zhao+JJ%22">Zhao JJ</searchLink>; Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Haematology-Oncology, National University Cancer Institute, Singapore; Department of Medicine, National University Hospital, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Lee+ARYB%22">Lee ARYB</searchLink>; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Kim+G%22">Kim G</searchLink>; Division of Upper Gastrointestinal Surgery, Department of Surgery, National University Hospital, National University Health System, Singapore.<br /><searchLink fieldCode="AU" term="%22Tan+HL%22">Tan HL</searchLink>; Department of Haematology-Oncology, National University Cancer Institute, Singapore.<br /><searchLink fieldCode="AU" term="%22Pang+A%22">Pang A</searchLink>; Division of Upper Gastrointestinal Surgery, Department of Surgery, National University Hospital, National University Health System, Singapore.<br /><searchLink fieldCode="AU" term="%22Shabbir+A%22">Shabbir A</searchLink>; Division of Upper Gastrointestinal Surgery, Department of Surgery, National University Hospital, National University Health System, Singapore.<br /><searchLink fieldCode="AU" term="%22Willaert+W%22">Willaert W</searchLink>; Department of Gastrointestinal Surgery, Ghent University Hospital, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Ma+H%22">Ma H</searchLink>; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Huang+KK%22">Huang KK</searchLink>; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Hagihara+T%22">Hagihara T</searchLink>; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Tan+ALK%22">Tan ALK</searchLink>; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Ong+CJ%22">Ong CJ</searchLink>; Singapore Gastric Cancer Consortium, Singapore; Department of Sarcoma, Peritoneal and Rare Tumors (SPRinT), Division of Surgery and Surgical Oncology, National Cancer Centre Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Wong+JSM%22">Wong JSM</searchLink>; Department of Sarcoma, Peritoneal and Rare Tumors (SPRinT), Division of Surgery and Surgical Oncology, National Cancer Centre Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Seo+CJ%22">Seo CJ</searchLink>; Department of Sarcoma, Peritoneal and Rare Tumors (SPRinT), Division of Surgery and Surgical Oncology, National Cancer Centre Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Walsh+R%22">Walsh R</searchLink>; Department of Haematology-Oncology, National University Cancer Institute, Singapore.<br /><searchLink fieldCode="AU" term="%22Chan+G%22">Chan G</searchLink>; Department of Haematology-Oncology, National University Cancer Institute, Singapore.<br /><searchLink fieldCode="AU" term="%22Cheo+SW%22">Cheo SW</searchLink>; Department of Haematology-Oncology, National University Cancer Institute, Singapore.<br /><searchLink fieldCode="AU" term="%22Soh+CCC%22">Soh CCC</searchLink>; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Callebout+E%22">Callebout E</searchLink>; Department of Digestive Oncology, Gastroenterology, Ghent University Hospital, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Geboes+K%22">Geboes K</searchLink>; Department of Gastrointestinal Surgery, Ghent University Hospital, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Ng+MCH%22">Ng MCH</searchLink>; Division of Medical Oncology, National Cancer Centre, Singapore; Duke NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Lum+JHY%22">Lum JHY</searchLink>; Department of Pathology, National University Hospital, Singapore.<br /><searchLink fieldCode="AU" term="%22Leow+WQ%22">Leow WQ</searchLink>; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Selvarajan+S%22">Selvarajan S</searchLink>; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Hoorens+A%22">Hoorens A</searchLink>; Department of Pathology, Ghent University Hospital, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Ang+WH%22">Ang WH</searchLink>; Department of Chemistry, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Pang+H%22">Pang H</searchLink>; Department of Chemistry, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tan+P%22">Tan P</searchLink>; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore; Singapore Gastric Cancer Consortium, Singapore.<br /><searchLink fieldCode="AU" term="%22Yong+WP%22">Yong WP</searchLink>; Department of Haematology-Oncology, National University Cancer Institute, Singapore; Singapore Gastric Cancer Consortium, Singapore.<br /><searchLink fieldCode="AU" term="%22Chia+CSL%22">Chia CSL</searchLink>; Department of Sarcoma, Peritoneal and Rare Tumors (SPRinT), Division of Surgery and Surgical Oncology, National Cancer Centre Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ceelen+W%22">Ceelen W</searchLink>; Department of Gastrointestinal Surgery, Ghent University Hospital, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22So+JBY%22">So JBY</searchLink>; Singapore Gastric Cancer Consortium, Singapore; Division of Upper Gastrointestinal Surgery, Department of Surgery, National University Hospital, National University Health System, Singapore; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Division of Surgical Oncology, National University Cancer Institute of Singapore (NCIS), Singapore, Singapore. Electronic address: sursbyj@nus.edu.sg.
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  Data: <searchLink fieldCode="JN" term="%22101690685%22">ESMO open</searchLink> [ESMO Open] 2024 Sep; Vol. 9 (9), pp. 103681. <i>Date of Electronic Publication: </i>2024 Sep 16.
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