Cardiac NAD+ depletion in mice promotes hypertrophic cardiomyopathy and arrhythmias prior to impaired bioenergetics.

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Title: Cardiac NAD+ depletion in mice promotes hypertrophic cardiomyopathy and arrhythmias prior to impaired bioenergetics.
Authors: Doan KV; Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Luongo TS; Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Ts'olo TT; Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Lee WD; Lewis-Sigler Institute for Integrative Genomics, Department of Chemistry, Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ, USA., Frederick DW; Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Mukherjee S; Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Adzika GK; Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Perry CE; Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Gaspar RB; Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Walker N; Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Blair MC; Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Bye N; Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Davis JG; Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Holman CD; Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Chu Q; Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Wang L; Lewis-Sigler Institute for Integrative Genomics, Department of Chemistry, Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ, USA.; Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Rabinowitz JD; Lewis-Sigler Institute for Integrative Genomics, Department of Chemistry, Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ, USA., Kelly DP; Department of Medicine, Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Cappola TP; Department of Medicine, Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Margulies KB; Department of Medicine, Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Baur JA; Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. baur@pennmedicine.upenn.edu.
Source: Nature cardiovascular research [Nat Cardiovasc Res] 2024 Oct; Vol. 3 (10), pp. 1236-1248. Date of Electronic Publication: 2024 Sep 18.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 9918284280206676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2731-0590 (Electronic) Linking ISSN: 27310590 NLM ISO Abbreviation: Nat Cardiovasc Res Subsets: MEDLINE
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  Data: Cardiac NAD<superscript>+</superscript> depletion in mice promotes hypertrophic cardiomyopathy and arrhythmias prior to impaired bioenergetics.
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  Data: <searchLink fieldCode="AU" term="%22Doan+KV%22">Doan KV</searchLink>; Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Luongo+TS%22">Luongo TS</searchLink>; Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Ts'olo+TT%22">Ts'olo TT</searchLink>; Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Lee+WD%22">Lee WD</searchLink>; Lewis-Sigler Institute for Integrative Genomics, Department of Chemistry, Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Frederick+DW%22">Frederick DW</searchLink>; Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Mukherjee+S%22">Mukherjee S</searchLink>; Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Adzika+GK%22">Adzika GK</searchLink>; Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Perry+CE%22">Perry CE</searchLink>; Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Gaspar+RB%22">Gaspar RB</searchLink>; Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Walker+N%22">Walker N</searchLink>; Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Blair+MC%22">Blair MC</searchLink>; Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Bye+N%22">Bye N</searchLink>; Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Davis+JG%22">Davis JG</searchLink>; Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Holman+CD%22">Holman CD</searchLink>; Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Chu+Q%22">Chu Q</searchLink>; Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Lewis-Sigler Institute for Integrative Genomics, Department of Chemistry, Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ, USA.; Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Rabinowitz+JD%22">Rabinowitz JD</searchLink>; Lewis-Sigler Institute for Integrative Genomics, Department of Chemistry, Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Kelly+DP%22">Kelly DP</searchLink>; Department of Medicine, Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Cappola+TP%22">Cappola TP</searchLink>; Department of Medicine, Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Margulies+KB%22">Margulies KB</searchLink>; Department of Medicine, Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Baur+JA%22">Baur JA</searchLink>; Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. baur@pennmedicine.upenn.edu.
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  Data: <searchLink fieldCode="JN" term="%229918284280206676%22">Nature cardiovascular research</searchLink> [Nat Cardiovasc Res] 2024 Oct; Vol. 3 (10), pp. 1236-1248. <i>Date of Electronic Publication: </i>2024 Sep 18.
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