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Selective degradation of mutant FMS-like tyrosine kinase-3 requires BIM-dependent depletion of heat shock proteins.

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Title: Selective degradation of mutant FMS-like tyrosine kinase-3 requires BIM-dependent depletion of heat shock proteins.
Authors: Halilovic M; Department of Toxicology, University Medical Center, 55131, Mainz, Germany., Abdelsalam M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.; Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther-University of Halle-Wittenberg, Halle, Saale, Germany., Zabkiewicz J; Academic Department of Haematology, University of Cardiff, Heath Park, Cardiff, UK., Lazenby M; Academic Department of Haematology, University of Cardiff, Heath Park, Cardiff, UK., Alvares C; Academic Department of Haematology, University of Cardiff, Heath Park, Cardiff, UK., Schmidt M; Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther-University of Halle-Wittenberg, Halle, Saale, Germany., Brenner W; Clinic for Obstetrics and Women's Health, University Medical Center, 55131, Mainz, Germany., Najafi S; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology (B310), German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases Heidelberg, Heidelberg, Germany., Oehme I; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology (B310), German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases Heidelberg, Heidelberg, Germany., Hieber C; Department of Dermatology, University Medical Center Mainz, Mainz, Germany., Zeyn Y; Department of Dermatology, University Medical Center Mainz, Mainz, Germany., Bros M; Department of Dermatology, University Medical Center Mainz, Mainz, Germany., Sippl W; Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther-University of Halle-Wittenberg, Halle, Saale, Germany. wolfgang.sippl@pharmazie.uni-halle.de., Krämer OH; Department of Toxicology, University Medical Center, 55131, Mainz, Germany. okraemer@uni-mainz.de.
Source: Leukemia [Leukemia] 2024 Dec; Vol. 38 (12), pp. 2561-2572. Date of Electronic Publication: 2024 Sep 17.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Selective degradation of mutant FMS-like tyrosine kinase-3 requires BIM-dependent depletion of heat shock proteins.
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  Data: <searchLink fieldCode="AU" term="%22Halilovic+M%22">Halilovic M</searchLink>; Department of Toxicology, University Medical Center, 55131, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Abdelsalam+M%22">Abdelsalam M</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.; Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther-University of Halle-Wittenberg, Halle, Saale, Germany.<br /><searchLink fieldCode="AU" term="%22Zabkiewicz+J%22">Zabkiewicz J</searchLink>; Academic Department of Haematology, University of Cardiff, Heath Park, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Lazenby+M%22">Lazenby M</searchLink>; Academic Department of Haematology, University of Cardiff, Heath Park, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Alvares+C%22">Alvares C</searchLink>; Academic Department of Haematology, University of Cardiff, Heath Park, Cardiff, UK.<br /><searchLink fieldCode="AU" term="%22Schmidt+M%22">Schmidt M</searchLink>; Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther-University of Halle-Wittenberg, Halle, Saale, Germany.<br /><searchLink fieldCode="AU" term="%22Brenner+W%22">Brenner W</searchLink>; Clinic for Obstetrics and Women's Health, University Medical Center, 55131, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Najafi+S%22">Najafi S</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology (B310), German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Oehme+I%22">Oehme I</searchLink>; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology (B310), German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hieber+C%22">Hieber C</searchLink>; Department of Dermatology, University Medical Center Mainz, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Zeyn+Y%22">Zeyn Y</searchLink>; Department of Dermatology, University Medical Center Mainz, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Bros+M%22">Bros M</searchLink>; Department of Dermatology, University Medical Center Mainz, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Sippl+W%22">Sippl W</searchLink>; Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther-University of Halle-Wittenberg, Halle, Saale, Germany. wolfgang.sippl@pharmazie.uni-halle.de.<br /><searchLink fieldCode="AU" term="%22Krämer+OH%22">Krämer OH</searchLink>; Department of Toxicology, University Medical Center, 55131, Mainz, Germany. okraemer@uni-mainz.de.
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  Data: <searchLink fieldCode="JN" term="%228704895%22">Leukemia</searchLink> [Leukemia] 2024 Dec; Vol. 38 (12), pp. 2561-2572. <i>Date of Electronic Publication: </i>2024 Sep 17.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%2C+Specialist+Journals%22">Nature Publishing Group, Specialist Journals </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8704895 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-5551 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2208876924%22">08876924 </searchLink><i>NLM ISO Abbreviation: </i>Leukemia <i>Subsets: </i>MEDLINE
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              Text: 2024 Dec
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