Selective degradation of mutant FMS-like tyrosine kinase-3 requires BIM-dependent depletion of heat shock proteins.
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| Title: | Selective degradation of mutant FMS-like tyrosine kinase-3 requires BIM-dependent depletion of heat shock proteins. |
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| Authors: | Halilovic M; Department of Toxicology, University Medical Center, 55131, Mainz, Germany., Abdelsalam M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.; Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther-University of Halle-Wittenberg, Halle, Saale, Germany., Zabkiewicz J; Academic Department of Haematology, University of Cardiff, Heath Park, Cardiff, UK., Lazenby M; Academic Department of Haematology, University of Cardiff, Heath Park, Cardiff, UK., Alvares C; Academic Department of Haematology, University of Cardiff, Heath Park, Cardiff, UK., Schmidt M; Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther-University of Halle-Wittenberg, Halle, Saale, Germany., Brenner W; Clinic for Obstetrics and Women's Health, University Medical Center, 55131, Mainz, Germany., Najafi S; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology (B310), German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases Heidelberg, Heidelberg, Germany., Oehme I; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Clinical Cooperation Unit Pediatric Oncology (B310), German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases Heidelberg, Heidelberg, Germany., Hieber C; Department of Dermatology, University Medical Center Mainz, Mainz, Germany., Zeyn Y; Department of Dermatology, University Medical Center Mainz, Mainz, Germany., Bros M; Department of Dermatology, University Medical Center Mainz, Mainz, Germany., Sippl W; Department of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther-University of Halle-Wittenberg, Halle, Saale, Germany. wolfgang.sippl@pharmazie.uni-halle.de., Krämer OH; Department of Toxicology, University Medical Center, 55131, Mainz, Germany. okraemer@uni-mainz.de. |
| Source: | Leukemia [Leukemia] 2024 Dec; Vol. 38 (12), pp. 2561-2572. Date of Electronic Publication: 2024 Sep 17. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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