Venetoclax plus decitabine as a bridge to allogeneic haematopoietic stem-cell transplantation in older patients with acute myeloid leukaemia (VEN-DEC GITMO): final report of a multicentre, single-arm, phase 2 trial.
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| Title: | Venetoclax plus decitabine as a bridge to allogeneic haematopoietic stem-cell transplantation in older patients with acute myeloid leukaemia (VEN-DEC GITMO): final report of a multicentre, single-arm, phase 2 trial. |
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| Authors: | Russo D; Department of Clinical and Experimental Science, University of Brescia, ASST Spedali Civili di Brescia, Brescia, Italy. Electronic address: domenico.russo@unibs.it., Polverelli N; Department of Molecular Medicine, Division of Hematology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy., Bernardi S; Department of Clinical and Experimental Science, University of Brescia, ASST Spedali Civili di Brescia, Brescia, Italy; Centro di Ricerca Emato-Oncologica AIL, ASST Spedali Civili di Brescia, Brescia, Italy; National Center for Gene Therapy and Drug based on RNA Technology, Padova, Italy., Santarone S; Centro Trapianti Midollo Osseo, Azienda Sanitaria Locale di Pescara, Pescara, Italy., Farina M; Department of Clinical and Experimental Science, University of Brescia, ASST Spedali Civili di Brescia, Brescia, Italy., Borlenghi E; Division of Hematology, ASST Spedali Civili di Brescia, Brescia, Italy., Onida F; MTN Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, ASST Fatebenefratelli-Sacco, University of Milan, Milan, Italy., Castagna L; Bone Marrow Transplantation Unit, Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy., Bramanti S; Humanitas Clinical and Research Center, IRCCS, Rozzano, Italy., Carella AM; IRCCS Ospedale Casa Sollievo della Sofferenza, Foggia, Italy., Sorasio R; Department of Hematology, S Croce e Carle Hospital, Cuneo, Italy., Martino M; Centro Unico Trapianti, Division of Hematology, Grande Ospedale Metropolitano Bianchi Melacrino Morelli, Reggio Calabria, Italy., Alati C; Centro Unico Trapianti, Division of Hematology, Grande Ospedale Metropolitano Bianchi Melacrino Morelli, Reggio Calabria, Italy., Olivieri A; Clinica di Ematologia Azienda Ospedaliero Universitaria delle Marche, Ancona, Italy., Beltrami G; UO Ematologia e Terapie Cellulari, IRCCS Azienda Ospedaliera Universitaria San Martino, Genova, Italy., Curti A; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia Seràgnoli, Bologna, Italy., Vetro C; Division of Hematology, BMT Unit, AOU Policlinico G Rodolico S Marco, Catania, Italy., Leotta S; Division of Hematology, BMT Unit, AOU Policlinico G Rodolico S Marco, Catania, Italy., Mancini V; Department of Hematology, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy., Terruzzi E; Department of Hematology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy., Bernardi M; Unit of Hematology and Bone Marrow Transplantation, IRCCS Ospedale San Raffaele, Milan, Italy., Galieni P; UOC Hematology, Mazzoni Hospital Ascoli Piceno, Ascoli Piceno, Italy., Musto P; UOC Ematologia, Bari, Italy., Cerretti R; Department of Hematology, Stem Cell Transplant Unit, Policlinico Tor Vergata, Rome, Italy., Giaccone L; Univesity of Torino, AOU Città Della Salute E Della Scienza Di Torino, Torino, Italy., Skert C; Unit of Haematology and Bone Marrow Transplantation, Ospedale Dell'Angelo, Venezia Mestre, Italy., Radici V; Department of Clinical and Experimental Science, University of Brescia, ASST Spedali Civili di Brescia, Brescia, Italy., Vezzoli M; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy., Calza S; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy., Leoni A; Department of Clinical and Experimental Science, University of Brescia, ASST Spedali Civili di Brescia, Brescia, Italy; Centro di Ricerca Emato-Oncologica AIL, ASST Spedali Civili di Brescia, Brescia, Italy., Garuffo L; Department of Clinical and Experimental Science, University of Brescia, ASST Spedali Civili di Brescia, Brescia, Italy; Centro di Ricerca Emato-Oncologica AIL, ASST Spedali Civili di Brescia, Brescia, Italy., Bonvicini C; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni Di Dio Fatebenefratelli, Brescia, Italy., Pellizzeri S; Department of Clinical and Experimental Science, University of Brescia, ASST Spedali Civili di Brescia, Brescia, Italy., Malagola M; Department of Clinical and Experimental Science, University of Brescia, ASST Spedali Civili di Brescia, Brescia, Italy., Ciceri F; Unit of Hematology and Stem Cell Transplantation, Ospedale San Raffaele, University Vita-Salute San Raffaele, Milan, Italy. |
| Source: | The Lancet. Haematology [Lancet Haematol] 2024 Nov; Vol. 11 (11), pp. e830-e838. Date of Electronic Publication: 2024 Sep 20. |
| Publication Type: | Journal Article; Clinical Trial, Phase II; Multicenter Study |
| Journal Info: | Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101643584 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3026 (Electronic) Linking ISSN: 23523026 NLM ISO Abbreviation: Lancet Haematol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 39312920 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Venetoclax plus decitabine as a bridge to allogeneic haematopoietic stem-cell transplantation in older patients with acute myeloid leukaemia (VEN-DEC GITMO): final report of a multicentre, single-arm, phase 2 trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Russo+D%22">Russo D</searchLink>; Department of Clinical and Experimental Science, University of Brescia, ASST Spedali Civili di Brescia, Brescia, Italy. Electronic address: domenico.russo@unibs.it.<br /><searchLink fieldCode="AU" term="%22Polverelli+N%22">Polverelli N</searchLink>; Department of Molecular Medicine, Division of Hematology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Bernardi+S%22">Bernardi S</searchLink>; Department of Clinical and Experimental Science, University of Brescia, ASST Spedali Civili di Brescia, Brescia, Italy; Centro di Ricerca Emato-Oncologica AIL, ASST Spedali Civili di Brescia, Brescia, Italy; National Center for Gene Therapy and Drug based on RNA Technology, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Santarone+S%22">Santarone S</searchLink>; Centro Trapianti Midollo Osseo, Azienda Sanitaria Locale di Pescara, Pescara, Italy.<br /><searchLink fieldCode="AU" term="%22Farina+M%22">Farina M</searchLink>; Department of Clinical and Experimental Science, University of Brescia, ASST Spedali Civili di Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Borlenghi+E%22">Borlenghi E</searchLink>; Division of Hematology, ASST Spedali Civili di Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Onida+F%22">Onida F</searchLink>; MTN Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, ASST Fatebenefratelli-Sacco, University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Castagna+L%22">Castagna L</searchLink>; Bone Marrow Transplantation Unit, Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy.<br /><searchLink fieldCode="AU" term="%22Bramanti+S%22">Bramanti S</searchLink>; Humanitas Clinical and Research Center, IRCCS, Rozzano, Italy.<br /><searchLink fieldCode="AU" term="%22Carella+AM%22">Carella AM</searchLink>; IRCCS Ospedale Casa Sollievo della Sofferenza, Foggia, Italy.<br /><searchLink fieldCode="AU" term="%22Sorasio+R%22">Sorasio R</searchLink>; Department of Hematology, S Croce e Carle Hospital, Cuneo, Italy.<br /><searchLink fieldCode="AU" term="%22Martino+M%22">Martino M</searchLink>; Centro Unico Trapianti, Division of Hematology, Grande Ospedale Metropolitano Bianchi Melacrino Morelli, Reggio Calabria, Italy.<br /><searchLink fieldCode="AU" term="%22Alati+C%22">Alati C</searchLink>; Centro Unico Trapianti, Division of Hematology, Grande Ospedale Metropolitano Bianchi Melacrino Morelli, Reggio Calabria, Italy.<br /><searchLink fieldCode="AU" term="%22Olivieri+A%22">Olivieri A</searchLink>; Clinica di Ematologia Azienda Ospedaliero Universitaria delle Marche, Ancona, Italy.<br /><searchLink fieldCode="AU" term="%22Beltrami+G%22">Beltrami G</searchLink>; UO Ematologia e Terapie Cellulari, IRCCS Azienda Ospedaliera Universitaria San Martino, Genova, Italy.<br /><searchLink fieldCode="AU" term="%22Curti+A%22">Curti A</searchLink>; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia Seràgnoli, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Vetro+C%22">Vetro C</searchLink>; Division of Hematology, BMT Unit, AOU Policlinico G Rodolico S Marco, Catania, Italy.<br /><searchLink fieldCode="AU" term="%22Leotta+S%22">Leotta S</searchLink>; Division of Hematology, BMT Unit, AOU Policlinico G Rodolico S Marco, Catania, Italy.<br /><searchLink fieldCode="AU" term="%22Mancini+V%22">Mancini V</searchLink>; Department of Hematology, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Terruzzi+E%22">Terruzzi E</searchLink>; Department of Hematology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.<br /><searchLink fieldCode="AU" term="%22Bernardi+M%22">Bernardi M</searchLink>; Unit of Hematology and Bone Marrow Transplantation, IRCCS Ospedale San Raffaele, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Galieni+P%22">Galieni P</searchLink>; UOC Hematology, Mazzoni Hospital Ascoli Piceno, Ascoli Piceno, Italy.<br /><searchLink fieldCode="AU" term="%22Musto+P%22">Musto P</searchLink>; UOC Ematologia, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Cerretti+R%22">Cerretti R</searchLink>; Department of Hematology, Stem Cell Transplant Unit, Policlinico Tor Vergata, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Giaccone+L%22">Giaccone L</searchLink>; Univesity of Torino, AOU Città Della Salute E Della Scienza Di Torino, Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Skert+C%22">Skert C</searchLink>; Unit of Haematology and Bone Marrow Transplantation, Ospedale Dell'Angelo, Venezia Mestre, Italy.<br /><searchLink fieldCode="AU" term="%22Radici+V%22">Radici V</searchLink>; Department of Clinical and Experimental Science, University of Brescia, ASST Spedali Civili di Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Vezzoli+M%22">Vezzoli M</searchLink>; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Calza+S%22">Calza S</searchLink>; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Leoni+A%22">Leoni A</searchLink>; Department of Clinical and Experimental Science, University of Brescia, ASST Spedali Civili di Brescia, Brescia, Italy; Centro di Ricerca Emato-Oncologica AIL, ASST Spedali Civili di Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Garuffo+L%22">Garuffo L</searchLink>; Department of Clinical and Experimental Science, University of Brescia, ASST Spedali Civili di Brescia, Brescia, Italy; Centro di Ricerca Emato-Oncologica AIL, ASST Spedali Civili di Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Bonvicini+C%22">Bonvicini C</searchLink>; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni Di Dio Fatebenefratelli, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Pellizzeri+S%22">Pellizzeri S</searchLink>; Department of Clinical and Experimental Science, University of Brescia, ASST Spedali Civili di Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Malagola+M%22">Malagola M</searchLink>; Department of Clinical and Experimental Science, University of Brescia, ASST Spedali Civili di Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Ciceri+F%22">Ciceri F</searchLink>; Unit of Hematology and Stem Cell Transplantation, Ospedale San Raffaele, University Vita-Salute San Raffaele, Milan, Italy. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101643584%22">The Lancet. Haematology</searchLink> [Lancet Haematol] 2024 Nov; Vol. 11 (11), pp. e830-e838. <i>Date of Electronic Publication: </i>2024 Sep 20. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Clinical Trial, Phase II; Multicenter Study – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Ltd%22">Elsevier Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101643584 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2352-3026 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223523026%22">23523026 </searchLink><i>NLM ISO Abbreviation: </i>Lancet Haematol <i>Subsets: </i>MEDLINE |
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