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First Demonstration of In Vivo PDE11A4 Target Engagement for Potential Treatment of Age-Related Memory Disorders.

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Title: First Demonstration of In Vivo PDE11A4 Target Engagement for Potential Treatment of Age-Related Memory Disorders.
Authors: Mahmood SU; Department of Chemistry and Biochemistry, Montclair State University, 1 Normal Avenue, Montclair, New Jersey 07043, United States.; Sokol Institute for Pharmaceutical Life Sciences, Montclair State University, Montclair, New Jersey 07043, United States., Eberhard J; Biology Department, Boston College, Chestnut Hill, Massachusetts 02467, United States., Hoffman CS; Biology Department, Boston College, Chestnut Hill, Massachusetts 02467, United States., Colussi D; Moulder Center for Drug Discovery Research, Temple University, Philadelphia, Pennsylvania 19140, United States., Gordon J; Moulder Center for Drug Discovery Research, Temple University, Philadelphia, Pennsylvania 19140, United States., Childers W; Moulder Center for Drug Discovery Research, Temple University, Philadelphia, Pennsylvania 19140, United States., Amurrio E; Department of Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States., Patel J; Department of Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States., Kelly MP; Department of Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States.; Center for Research on Aging, University of Maryland, Baltimore School of Medicine, Baltimore, Maryland 21201, United States., Rotella DP; Department of Chemistry and Biochemistry, Montclair State University, 1 Normal Avenue, Montclair, New Jersey 07043, United States.; Sokol Institute for Pharmaceutical Life Sciences, Montclair State University, Montclair, New Jersey 07043, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2024 Oct 10; Vol. 67 (19), pp. 17774-17784. Date of Electronic Publication: 2024 Sep 25.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Mahmood+SU%22">Mahmood SU</searchLink>; Department of Chemistry and Biochemistry, Montclair State University, 1 Normal Avenue, Montclair, New Jersey 07043, United States.; Sokol Institute for Pharmaceutical Life Sciences, Montclair State University, Montclair, New Jersey 07043, United States.<br /><searchLink fieldCode="AU" term="%22Eberhard+J%22">Eberhard J</searchLink>; Biology Department, Boston College, Chestnut Hill, Massachusetts 02467, United States.<br /><searchLink fieldCode="AU" term="%22Hoffman+CS%22">Hoffman CS</searchLink>; Biology Department, Boston College, Chestnut Hill, Massachusetts 02467, United States.<br /><searchLink fieldCode="AU" term="%22Colussi+D%22">Colussi D</searchLink>; Moulder Center for Drug Discovery Research, Temple University, Philadelphia, Pennsylvania 19140, United States.<br /><searchLink fieldCode="AU" term="%22Gordon+J%22">Gordon J</searchLink>; Moulder Center for Drug Discovery Research, Temple University, Philadelphia, Pennsylvania 19140, United States.<br /><searchLink fieldCode="AU" term="%22Childers+W%22">Childers W</searchLink>; Moulder Center for Drug Discovery Research, Temple University, Philadelphia, Pennsylvania 19140, United States.<br /><searchLink fieldCode="AU" term="%22Amurrio+E%22">Amurrio E</searchLink>; Department of Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States.<br /><searchLink fieldCode="AU" term="%22Patel+J%22">Patel J</searchLink>; Department of Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States.<br /><searchLink fieldCode="AU" term="%22Kelly+MP%22">Kelly MP</searchLink>; Department of Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States.; Center for Research on Aging, University of Maryland, Baltimore School of Medicine, Baltimore, Maryland 21201, United States.<br /><searchLink fieldCode="AU" term="%22Rotella+DP%22">Rotella DP</searchLink>; Department of Chemistry and Biochemistry, Montclair State University, 1 Normal Avenue, Montclair, New Jersey 07043, United States.; Sokol Institute for Pharmaceutical Life Sciences, Montclair State University, Montclair, New Jersey 07043, United States.
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        Value: 10.1021/acs.jmedchem.4c01794
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              Text: 2024 Oct 10
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