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Discovery of Arylpiperazines with Broad-Spectrum Antimicrobial Activity and Favorable Pharmacokinetic Profiles.

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Title: Discovery of Arylpiperazines with Broad-Spectrum Antimicrobial Activity and Favorable Pharmacokinetic Profiles.
Authors: da Silva Oliveira DD; Laboratório de Síntese de Candidatos a Fármacos (LaSFar), Institute of Chemistry, Federal University of Uberlândia, Uberlândia-MG, 38400-902, Brazil., Sousa Silva NB; Laboratory of Antimicrobial Testing (LEA), Institute of Biomedical Sciences (ICBIM), Federal University of Uberlândia, Uberlândia-MG, 38400-902, Brazil., Jacques Dit Lapierre TJW; Laboratório de Síntese de Candidatos a Fármacos (LaSFar), Institute of Chemistry, Federal University of Uberlândia, Uberlândia-MG, 38400-902, Brazil., Lemes de Souza S; Laboratory of Antimicrobial Testing (LEA), Institute of Biomedical Sciences (ICBIM), Federal University of Uberlândia, Uberlândia-MG, 38400-902, Brazil., Ferreira Brito NP; Laboratório de Síntese de Candidatos a Fármacos (LaSFar), Institute of Chemistry, Federal University of Uberlândia, Uberlândia-MG, 38400-902, Brazil., Cassiano Martinho AC; Laboratório de Síntese de Candidatos a Fármacos (LaSFar), Institute of Chemistry, Federal University of Uberlândia, Uberlândia-MG, 38400-902, Brazil., Clemente Dias RF; Laboratório de Síntese de Candidatos a Fármacos (LaSFar), Institute of Chemistry, Federal University of Uberlândia, Uberlândia-MG, 38400-902, Brazil., Nascimento Farago D; Laboratório de Síntese de Candidatos a Fármacos (LaSFar), Institute of Chemistry, Federal University of Uberlândia, Uberlândia-MG, 38400-902, Brazil., Michelan-Duarte S; Laboratório de Química Medicinal e Computacional (LQMC), Instituto de Física de São Carlos (IFSC), Universidade de São Paulo (USP), São Carlos-SP, 13563-120, Brazil., Consolin Chelucci R; Laboratório de Química Medicinal e Computacional (LQMC), Instituto de Física de São Carlos (IFSC), Universidade de São Paulo (USP), São Carlos-SP, 13563-120, Brazil., de Moura Lodi Cruz MGF; Grupo de Genômica Funcional de Parasitos, Instituto René Rachou, Fundação Oswaldo Cruz (FIOCRUZ Minas), Belo Horizonte-MG, 30190-002, Brazil., de Melo Resende D; Grupo de Genômica Funcional de Parasitos, Instituto René Rachou, Fundação Oswaldo Cruz (FIOCRUZ Minas), Belo Horizonte-MG, 30190-002, Brazil., Andricopulo AD; Laboratório de Química Medicinal e Computacional (LQMC), Instituto de Física de São Carlos (IFSC), Universidade de São Paulo (USP), São Carlos-SP, 13563-120, Brazil., Fonseca Murta SM; Grupo de Genômica Funcional de Parasitos, Instituto René Rachou, Fundação Oswaldo Cruz (FIOCRUZ Minas), Belo Horizonte-MG, 30190-002, Brazil., Ferreira LLG; Laboratório de Química Medicinal e Computacional (LQMC), Instituto de Física de São Carlos (IFSC), Universidade de São Paulo (USP), São Carlos-SP, 13563-120, Brazil., Martins CHG; Laboratory of Antimicrobial Testing (LEA), Institute of Biomedical Sciences (ICBIM), Federal University of Uberlândia, Uberlândia-MG, 38400-902, Brazil., de Oliveira Rezende Júnior C; Laboratório de Síntese de Candidatos a Fármacos (LaSFar), Institute of Chemistry, Federal University of Uberlândia, Uberlândia-MG, 38400-902, Brazil.
Source: Chemistry & biodiversity [Chem Biodivers] 2025 Feb; Vol. 22 (2), pp. e202402100. Date of Electronic Publication: 2024 Nov 07.
Publication Type: Journal Article
Journal Info: Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE
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  Data: Discovery of Arylpiperazines with Broad-Spectrum Antimicrobial Activity and Favorable Pharmacokinetic Profiles.
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  Data: <searchLink fieldCode="AU" term="%22da+Silva+Oliveira+DD%22">da Silva Oliveira DD</searchLink>; Laboratório de Síntese de Candidatos a Fármacos (LaSFar), Institute of Chemistry, Federal University of Uberlândia, Uberlândia-MG, 38400-902, Brazil.<br /><searchLink fieldCode="AU" term="%22Sousa+Silva+NB%22">Sousa Silva NB</searchLink>; Laboratory of Antimicrobial Testing (LEA), Institute of Biomedical Sciences (ICBIM), Federal University of Uberlândia, Uberlândia-MG, 38400-902, Brazil.<br /><searchLink fieldCode="AU" term="%22Jacques+Dit+Lapierre+TJW%22">Jacques Dit Lapierre TJW</searchLink>; Laboratório de Síntese de Candidatos a Fármacos (LaSFar), Institute of Chemistry, Federal University of Uberlândia, Uberlândia-MG, 38400-902, Brazil.<br /><searchLink fieldCode="AU" term="%22Lemes+de+Souza+S%22">Lemes de Souza S</searchLink>; Laboratory of Antimicrobial Testing (LEA), Institute of Biomedical Sciences (ICBIM), Federal University of Uberlândia, Uberlândia-MG, 38400-902, Brazil.<br /><searchLink fieldCode="AU" term="%22Ferreira+Brito+NP%22">Ferreira Brito NP</searchLink>; Laboratório de Síntese de Candidatos a Fármacos (LaSFar), Institute of Chemistry, Federal University of Uberlândia, Uberlândia-MG, 38400-902, Brazil.<br /><searchLink fieldCode="AU" term="%22Cassiano+Martinho+AC%22">Cassiano Martinho AC</searchLink>; Laboratório de Síntese de Candidatos a Fármacos (LaSFar), Institute of Chemistry, Federal University of Uberlândia, Uberlândia-MG, 38400-902, Brazil.<br /><searchLink fieldCode="AU" term="%22Clemente+Dias+RF%22">Clemente Dias RF</searchLink>; Laboratório de Síntese de Candidatos a Fármacos (LaSFar), Institute of Chemistry, Federal University of Uberlândia, Uberlândia-MG, 38400-902, Brazil.<br /><searchLink fieldCode="AU" term="%22Nascimento+Farago+D%22">Nascimento Farago D</searchLink>; Laboratório de Síntese de Candidatos a Fármacos (LaSFar), Institute of Chemistry, Federal University of Uberlândia, Uberlândia-MG, 38400-902, Brazil.<br /><searchLink fieldCode="AU" term="%22Michelan-Duarte+S%22">Michelan-Duarte S</searchLink>; Laboratório de Química Medicinal e Computacional (LQMC), Instituto de Física de São Carlos (IFSC), Universidade de São Paulo (USP), São Carlos-SP, 13563-120, Brazil.<br /><searchLink fieldCode="AU" term="%22Consolin+Chelucci+R%22">Consolin Chelucci R</searchLink>; Laboratório de Química Medicinal e Computacional (LQMC), Instituto de Física de São Carlos (IFSC), Universidade de São Paulo (USP), São Carlos-SP, 13563-120, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Moura+Lodi+Cruz+MGF%22">de Moura Lodi Cruz MGF</searchLink>; Grupo de Genômica Funcional de Parasitos, Instituto René Rachou, Fundação Oswaldo Cruz (FIOCRUZ Minas), Belo Horizonte-MG, 30190-002, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Melo+Resende+D%22">de Melo Resende D</searchLink>; Grupo de Genômica Funcional de Parasitos, Instituto René Rachou, Fundação Oswaldo Cruz (FIOCRUZ Minas), Belo Horizonte-MG, 30190-002, Brazil.<br /><searchLink fieldCode="AU" term="%22Andricopulo+AD%22">Andricopulo AD</searchLink>; Laboratório de Química Medicinal e Computacional (LQMC), Instituto de Física de São Carlos (IFSC), Universidade de São Paulo (USP), São Carlos-SP, 13563-120, Brazil.<br /><searchLink fieldCode="AU" term="%22Fonseca+Murta+SM%22">Fonseca Murta SM</searchLink>; Grupo de Genômica Funcional de Parasitos, Instituto René Rachou, Fundação Oswaldo Cruz (FIOCRUZ Minas), Belo Horizonte-MG, 30190-002, Brazil.<br /><searchLink fieldCode="AU" term="%22Ferreira+LLG%22">Ferreira LLG</searchLink>; Laboratório de Química Medicinal e Computacional (LQMC), Instituto de Física de São Carlos (IFSC), Universidade de São Paulo (USP), São Carlos-SP, 13563-120, Brazil.<br /><searchLink fieldCode="AU" term="%22Martins+CHG%22">Martins CHG</searchLink>; Laboratory of Antimicrobial Testing (LEA), Institute of Biomedical Sciences (ICBIM), Federal University of Uberlândia, Uberlândia-MG, 38400-902, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Oliveira+Rezende+Júnior+C%22">de Oliveira Rezende Júnior C</searchLink>; Laboratório de Síntese de Candidatos a Fármacos (LaSFar), Institute of Chemistry, Federal University of Uberlândia, Uberlândia-MG, 38400-902, Brazil.
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  Data: <searchLink fieldCode="JN" term="%22101197449%22">Chemistry & biodiversity</searchLink> [Chem Biodivers] 2025 Feb; Vol. 22 (2), pp. e202402100. <i>Date of Electronic Publication: </i>2024 Nov 07.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Verlag+Helvetica+Chimica+Acta%22">Verlag Helvetica Chimica Acta </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101197449 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1612-1880 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216121872%22">16121872 </searchLink><i>NLM ISO Abbreviation: </i>Chem Biodivers <i>Subsets: </i>MEDLINE
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