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Protein kinase N1 deficiency results in upregulation of cerebral energy metabolism and is highly protective in in vivo and in vitro stroke models.

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Title: Protein kinase N1 deficiency results in upregulation of cerebral energy metabolism and is highly protective in in vivo and in vitro stroke models.
Authors: Zur Nedden S; Medical University of Innsbruck, CCB-Biocenter, Institute of Neurobiochemistry, Innrain 80-82, A-6020 Innsbruck, Austria. Electronic address: Stephanie.zur-Nedden@i-med.ac.at., Safari MS; Medical University of Innsbruck, CCB-Biocenter, Institute of Neurobiochemistry, Innrain 80-82, A-6020 Innsbruck, Austria., Weber D; Medical University of Innsbruck, CCB-Biocenter, Institute of Neurobiochemistry, Innrain 80-82, A-6020 Innsbruck, Austria., Kuenkel L; Medical University of Innsbruck, CCB-Biocenter, Institute of Neurobiochemistry, Innrain 80-82, A-6020 Innsbruck, Austria., Garmsiri C; Medical University of Innsbruck, CCB-Biocenter, Institute of Neurobiochemistry, Innrain 80-82, A-6020 Innsbruck, Austria., Lang L; Medical University of Innsbruck, CCB-Biocenter, Institute of Neurobiochemistry, Innrain 80-82, A-6020 Innsbruck, Austria., Orset C; Normandie University, UNICAEN, ESR3P, INSERM UMR-S U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), Institute of Blood and Brain @ Caen-Normandie (BB@C), GIP Cyceron, Caen, France., Freret T; Normandie University, UNICAEN, ESR3P, INSERM UMR-S U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), Institute of Blood and Brain @ Caen-Normandie (BB@C), GIP Cyceron, Caen, France., Haelewyn B; Normandie University, UNICAEN, ESR3P, INSERM UMR-S U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), Institute of Blood and Brain @ Caen-Normandie (BB@C), GIP Cyceron, Caen, France., Hotze M; University of Innsbruck, Department of Biochemistry, Institute of Bioanalytic & Intermediary Metabolism, 6020 Innsbruck, Austria., Kwiatkowski M; University of Innsbruck, Department of Biochemistry, Institute of Bioanalytic & Intermediary Metabolism, 6020 Innsbruck, Austria., Sarg B; Medical University of Innsbruck, CCB-Biocenter, Institute of Medical Biochemistry, Protein Core Facility, 6020 Innsbruck, Austria., Faserl K; Medical University of Innsbruck, CCB-Biocenter, Institute of Medical Biochemistry, Protein Core Facility, 6020 Innsbruck, Austria., Savic D; Medical University of Innsbruck, Laboratory for Experimental and Translational Research on Radiation Oncology (EXTRO-Lab), Department of Therapeutic Radiology and Oncology, 6020 Innsbruck, Austria; Tyrolean Cancer Research Institute, Innsbruck A-6020, Austria., Skvortsova II; Medical University of Innsbruck, Laboratory for Experimental and Translational Research on Radiation Oncology (EXTRO-Lab), Department of Therapeutic Radiology and Oncology, 6020 Innsbruck, Austria; Tyrolean Cancer Research Institute, Innsbruck A-6020, Austria., Krogsdam A; Medical University of Innsbruck, CCB-Biocenter, Institute of Bioinformatics, 6020 Innsbruck, Austria., Carollo S; Medical University of Innsbruck, CCB-Biocenter, Institute of Bioinformatics, 6020 Innsbruck, Austria., Trajanoski Z; Medical University of Innsbruck, CCB-Biocenter, Institute of Bioinformatics, 6020 Innsbruck, Austria., Oberacher H; Medical University of Innsbruck, Institute of Legal Medicine and Core Facility Metabolomics, 6020 Innsbruck, Austria., Zlotek D; Medical University of Innsbruck, CCB-Biocenter, Institute of Neurobiochemistry, Innrain 80-82, A-6020 Innsbruck, Austria., Ostermaier F; Medical University of Innsbruck, CCB-Biocenter, Institute of Neurobiochemistry, Innrain 80-82, A-6020 Innsbruck, Austria., Cameron A; Kinase Biology Laboratory, John Vane Science Centre, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK., Baier G; Medical University of Innsbruck, Institute for Cell Genetics, 6020 Innsbruck, Austria., Baier-Bitterlich G; Medical University of Innsbruck, CCB-Biocenter, Institute of Neurobiochemistry, Innrain 80-82, A-6020 Innsbruck, Austria.
Source: Metabolism: clinical and experimental [Metabolism] 2024 Dec; Vol. 161, pp. 156039. Date of Electronic Publication: 2024 Sep 26.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 0375267 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8600 (Electronic) Linking ISSN: 00260495 NLM ISO Abbreviation: Metabolism Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Protein kinase N1 deficiency results in upregulation of cerebral energy metabolism and is highly protective in in vivo and in vitro stroke models.
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  Data: <searchLink fieldCode="AU" term="%22Zur+Nedden+S%22">Zur Nedden S</searchLink>; Medical University of Innsbruck, CCB-Biocenter, Institute of Neurobiochemistry, Innrain 80-82, A-6020 Innsbruck, Austria. Electronic address: Stephanie.zur-Nedden@i-med.ac.at.<br /><searchLink fieldCode="AU" term="%22Safari+MS%22">Safari MS</searchLink>; Medical University of Innsbruck, CCB-Biocenter, Institute of Neurobiochemistry, Innrain 80-82, A-6020 Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Weber+D%22">Weber D</searchLink>; Medical University of Innsbruck, CCB-Biocenter, Institute of Neurobiochemistry, Innrain 80-82, A-6020 Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Kuenkel+L%22">Kuenkel L</searchLink>; Medical University of Innsbruck, CCB-Biocenter, Institute of Neurobiochemistry, Innrain 80-82, A-6020 Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Garmsiri+C%22">Garmsiri C</searchLink>; Medical University of Innsbruck, CCB-Biocenter, Institute of Neurobiochemistry, Innrain 80-82, A-6020 Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Lang+L%22">Lang L</searchLink>; Medical University of Innsbruck, CCB-Biocenter, Institute of Neurobiochemistry, Innrain 80-82, A-6020 Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Orset+C%22">Orset C</searchLink>; Normandie University, UNICAEN, ESR3P, INSERM UMR-S U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), Institute of Blood and Brain @ Caen-Normandie (BB@C), GIP Cyceron, Caen, France.<br /><searchLink fieldCode="AU" term="%22Freret+T%22">Freret T</searchLink>; Normandie University, UNICAEN, ESR3P, INSERM UMR-S U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), Institute of Blood and Brain @ Caen-Normandie (BB@C), GIP Cyceron, Caen, France.<br /><searchLink fieldCode="AU" term="%22Haelewyn+B%22">Haelewyn B</searchLink>; Normandie University, UNICAEN, ESR3P, INSERM UMR-S U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), Institute of Blood and Brain @ Caen-Normandie (BB@C), GIP Cyceron, Caen, France.<br /><searchLink fieldCode="AU" term="%22Hotze+M%22">Hotze M</searchLink>; University of Innsbruck, Department of Biochemistry, Institute of Bioanalytic & Intermediary Metabolism, 6020 Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Kwiatkowski+M%22">Kwiatkowski M</searchLink>; University of Innsbruck, Department of Biochemistry, Institute of Bioanalytic & Intermediary Metabolism, 6020 Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Sarg+B%22">Sarg B</searchLink>; Medical University of Innsbruck, CCB-Biocenter, Institute of Medical Biochemistry, Protein Core Facility, 6020 Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Faserl+K%22">Faserl K</searchLink>; Medical University of Innsbruck, CCB-Biocenter, Institute of Medical Biochemistry, Protein Core Facility, 6020 Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Savic+D%22">Savic D</searchLink>; Medical University of Innsbruck, Laboratory for Experimental and Translational Research on Radiation Oncology (EXTRO-Lab), Department of Therapeutic Radiology and Oncology, 6020 Innsbruck, Austria; Tyrolean Cancer Research Institute, Innsbruck A-6020, Austria.<br /><searchLink fieldCode="AU" term="%22Skvortsova+II%22">Skvortsova II</searchLink>; Medical University of Innsbruck, Laboratory for Experimental and Translational Research on Radiation Oncology (EXTRO-Lab), Department of Therapeutic Radiology and Oncology, 6020 Innsbruck, Austria; Tyrolean Cancer Research Institute, Innsbruck A-6020, Austria.<br /><searchLink fieldCode="AU" term="%22Krogsdam+A%22">Krogsdam A</searchLink>; Medical University of Innsbruck, CCB-Biocenter, Institute of Bioinformatics, 6020 Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Carollo+S%22">Carollo S</searchLink>; Medical University of Innsbruck, CCB-Biocenter, Institute of Bioinformatics, 6020 Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Trajanoski+Z%22">Trajanoski Z</searchLink>; Medical University of Innsbruck, CCB-Biocenter, Institute of Bioinformatics, 6020 Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Oberacher+H%22">Oberacher H</searchLink>; Medical University of Innsbruck, Institute of Legal Medicine and Core Facility Metabolomics, 6020 Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Zlotek+D%22">Zlotek D</searchLink>; Medical University of Innsbruck, CCB-Biocenter, Institute of Neurobiochemistry, Innrain 80-82, A-6020 Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Ostermaier+F%22">Ostermaier F</searchLink>; Medical University of Innsbruck, CCB-Biocenter, Institute of Neurobiochemistry, Innrain 80-82, A-6020 Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Cameron+A%22">Cameron A</searchLink>; Kinase Biology Laboratory, John Vane Science Centre, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.<br /><searchLink fieldCode="AU" term="%22Baier+G%22">Baier G</searchLink>; Medical University of Innsbruck, Institute for Cell Genetics, 6020 Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Baier-Bitterlich+G%22">Baier-Bitterlich G</searchLink>; Medical University of Innsbruck, CCB-Biocenter, Institute of Neurobiochemistry, Innrain 80-82, A-6020 Innsbruck, Austria.
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  Data: <searchLink fieldCode="JN" term="%220375267%22">Metabolism: clinical and experimental</searchLink> [Metabolism] 2024 Dec; Vol. 161, pp. 156039. <i>Date of Electronic Publication: </i>2024 Sep 26.
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