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Impact of essential genes on the success of genome editing experiments generating 3313 new genetically engineered mouse lines.

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Title: Impact of essential genes on the success of genome editing experiments generating 3313 new genetically engineered mouse lines.
Authors: Elrick H; The Centre for Phenogenomics, Toronto, ON, M5T 3H7, Canada.; The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada., Peterson KA; The Jackson Laboratory, Bar Harbor, ME, 04609, USA., Willis BJ; Mouse Biology Program, University of California-Davis, Davis, CA, 95618, USA., Lanza DG; Department of Molecular and Human Genetic, Baylor College of Medicine, Houston, TX, 77030, USA., Acar EF; The Centre for Phenogenomics, Toronto, ON, M5T 3H7, Canada.; The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada.; Department of Statistics, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada.; Department of Mathematics and Statistics, University of Guelph, Guelph, ON, N1G 2W1, Canada., Ryder EJ; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.; LGC Assure, Fordham, CB7 5WW, UK., Teboul L; The Mary Lyon Centre, MRC Harwell Institute, Harwell Campus, Didcot, Oxon, OX11 0RD, UK., Kasparek P; Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Vestec, Czech Republic.; Program in Craniofacial Biology and Department of Orofacial Sciences, University of California, San Francisco, San Francisco, CA, USA., Birling MC; CNRS, INSERM, CELPHEDIA, PHENOMIN, Institut Clinique de la Souris, Université de Strasbourg, Illkirch-Graffenstaden, France., Adams DJ; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK., Bradley A; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Trinity Lane, Cambridge, CB2 1TN, UK., Braun RE; The Jackson Laboratory, Bar Harbor, ME, 04609, USA., Brown SD; MRC Harwell Institute, Harwell, OX11 0RD, UK., Caulder A; The Mary Lyon Centre, MRC Harwell Institute, Harwell Campus, Didcot, Oxon, OX11 0RD, UK., Codner GF; The Mary Lyon Centre, MRC Harwell Institute, Harwell Campus, Didcot, Oxon, OX11 0RD, UK.; Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK., DeMayo FJ; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, 77030, USA.; Reproductive and Developmental Biology Laboratory, NIEHS, Research Triangle Park, Durham, NC, 27709, USA., Dickinson ME; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX, 77030, USA., Doe B; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.; The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK., Duddy G; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.; The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK., Gertsenstein M; The Centre for Phenogenomics, Toronto, ON, M5T 3H7, Canada., Goodwin LO; The Jackson Laboratory, Bar Harbor, ME, 04609, USA., Hérault Y; CNRS, INSERM, CELPHEDIA, PHENOMIN, Institut Clinique de la Souris, Université de Strasbourg, Illkirch-Graffenstaden, France., Lintott LG; The Centre for Phenogenomics, Toronto, ON, M5T 3H7, Canada.; The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada., Lloyd KCK; Mouse Biology Program, University of California-Davis, Davis, CA, 95618, USA.; Department of Surgery, School of Medicine, University of California Davis, Davis, CA, 95618, USA., Lorenzo I; Department of Molecular and Human Genetic, Baylor College of Medicine, Houston, TX, 77030, USA., Mackenzie M; The Mary Lyon Centre, MRC Harwell Institute, Harwell Campus, Didcot, Oxon, OX11 0RD, UK., Mallon AM; MRC Harwell Institute, Harwell, OX11 0RD, UK., McKerlie C; The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada., Parkinson H; European Molecular Biology Laboratory-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, UK., Ramirez-Solis R; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.; UT Health San Antonio, San Antonio, TX, 78229, USA., Seavitt JR; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.; Department of Molecular and Human Genetic, Baylor College of Medicine, Houston, TX, 77030, USA., Sedlacek R; Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences, Vestec, Czech Republic., Skarnes WC; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.; The Jackson Laboratory for Genomic Medicine, Farmington, CT, 06032, USA., Smedley D; William Harvey Research Institute, Queen Mary University of London, London, EC1M 6BQ, UK., Wells S; The Mary Lyon Centre, MRC Harwell Institute, Harwell Campus, Didcot, Oxon, OX11 0RD, UK., White JK; The Jackson Laboratory, Bar Harbor, ME, 04609, USA., Wood JA; The Jackson Laboratory, Bar Harbor, ME, 04609, USA.; Mouse Biology Program, University of California-Davis, Davis, CA, 95618, USA., Murray SA; The Jackson Laboratory, Bar Harbor, ME, 04609, USA., Heaney JD; Department of Molecular and Human Genetic, Baylor College of Medicine, Houston, TX, 77030, USA., Nutter LMJ; The Centre for Phenogenomics, Toronto, ON, M5T 3H7, Canada. lauryl.nutter@sickkids.ca.; The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada. lauryl.nutter@sickkids.ca.
Corporate Authors: International Mouse Phenotyping Consortium
Source: Scientific reports [Sci Rep] 2024 Sep 30; Vol. 14 (1), pp. 22626. Date of Electronic Publication: 2024 Sep 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2045-2322
DOI:10.1038/s41598-024-72418-8