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The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development.

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Title: The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development.
Authors: Gómez-Del Arco P; Institute for Rare Diseases Research, Instituto de Salud Carlos III (ISCIII). Majadahonda, Madrid, Spain. pgomez@isciii.es.; Gene Regulation in Cardiovascular Remodelling and Inflammation Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain. pgomez@isciii.es.; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. pgomez@isciii.es., Isern J; Altos Labs, Inc., San Diego Institute of Science, San Diego, CA, USA.; Tissue Regeneration Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain., Jimenez-Carretero D; Bioinformatics Unit, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain., López-Maderuelo D; Gene Regulation in Cardiovascular Remodelling and Inflammation Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.; Microscopy and Dynamic Imaging Unit, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain., Piñeiro-Sabarís R; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.; Intercellular Signaling in Cardiovascular Development and Disease Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain., El Abdellaoui-Soussi F; Institute for Rare Diseases Research, Instituto de Salud Carlos III (ISCIII). Majadahonda, Madrid, Spain.; Gene Regulation in Cardiovascular Remodelling and Inflammation Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.; Center for Stem Cells and Organoid Medicine (CuSTOM), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Torroja C; Bioinformatics Unit, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain., Vera-Pedrosa ML; Cardiac Arrhythmia Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain., Grima-Terrén M; Altos Labs, Inc., San Diego Institute of Science, San Diego, CA, USA.; Tissue Regeneration Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain., Benguria A; Genomics Unit, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain., Simón-Chica A; Novel Arrhythmogenic Mechanisms Program, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain., Queiro-Palou A; Institute for Rare Diseases Research, Instituto de Salud Carlos III (ISCIII). Majadahonda, Madrid, Spain.; Gene Regulation in Cardiovascular Remodelling and Inflammation Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.; Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden., Dopazo A; Genomics Unit, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain., Sánchez-Cabo F; Bioinformatics Unit, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain., Jalife J; Cardiac Arrhythmia Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.; University of Michigan, Ann Arbor, MI, USA., de la Pompa JL; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.; Intercellular Signaling in Cardiovascular Development and Disease Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain., Filgueiras-Rama D; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.; Novel Arrhythmogenic Mechanisms Program, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.; Cardiovascular Institute, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain., Muñoz-Cánoves P; Altos Labs, Inc., San Diego Institute of Science, San Diego, CA, USA. pmunozcanoves@altoslabs.com.; Tissue Regeneration Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain. pmunozcanoves@altoslabs.com.; Department of Experimental & Health Sciences, University Pompeu Fabra (UPF)/CIBERNED, Barcelona, Spain. pmunozcanoves@altoslabs.com.; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain. pmunozcanoves@altoslabs.com., Redondo JM; Gene Regulation in Cardiovascular Remodelling and Inflammation Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain. jmredondo@cbm.csic.es.; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. jmredondo@cbm.csic.es.; Cell-Cell Communication & Inflammation Unit, Centro de Biología Molecular Severo Ochoa (CBMSO), Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Madrid, Spain. jmredondo@cbm.csic.es.
Source: Nature communications [Nat Commun] 2024 Oct 04; Vol. 15 (1), pp. 8602. Date of Electronic Publication: 2024 Oct 04.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development.
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  Data: <searchLink fieldCode="AU" term="%22Gómez-Del+Arco+P%22">Gómez-Del Arco P</searchLink>; Institute for Rare Diseases Research, Instituto de Salud Carlos III (ISCIII). Majadahonda, Madrid, Spain. pgomez@isciii.es.; Gene Regulation in Cardiovascular Remodelling and Inflammation Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain. pgomez@isciii.es.; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. pgomez@isciii.es.<br /><searchLink fieldCode="AU" term="%22Isern+J%22">Isern J</searchLink>; Altos Labs, Inc., San Diego Institute of Science, San Diego, CA, USA.; Tissue Regeneration Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Jimenez-Carretero+D%22">Jimenez-Carretero D</searchLink>; Bioinformatics Unit, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22López-Maderuelo+D%22">López-Maderuelo D</searchLink>; Gene Regulation in Cardiovascular Remodelling and Inflammation Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.; Microscopy and Dynamic Imaging Unit, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Piñeiro-Sabarís+R%22">Piñeiro-Sabarís R</searchLink>; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.; Intercellular Signaling in Cardiovascular Development and Disease Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22El+Abdellaoui-Soussi+F%22">El Abdellaoui-Soussi F</searchLink>; Institute for Rare Diseases Research, Instituto de Salud Carlos III (ISCIII). Majadahonda, Madrid, Spain.; Gene Regulation in Cardiovascular Remodelling and Inflammation Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.; Center for Stem Cells and Organoid Medicine (CuSTOM), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Torroja+C%22">Torroja C</searchLink>; Bioinformatics Unit, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Vera-Pedrosa+ML%22">Vera-Pedrosa ML</searchLink>; Cardiac Arrhythmia Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Grima-Terrén+M%22">Grima-Terrén M</searchLink>; Altos Labs, Inc., San Diego Institute of Science, San Diego, CA, USA.; Tissue Regeneration Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Benguria+A%22">Benguria A</searchLink>; Genomics Unit, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Simón-Chica+A%22">Simón-Chica A</searchLink>; Novel Arrhythmogenic Mechanisms Program, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Queiro-Palou+A%22">Queiro-Palou A</searchLink>; Institute for Rare Diseases Research, Instituto de Salud Carlos III (ISCIII). Majadahonda, Madrid, Spain.; Gene Regulation in Cardiovascular Remodelling and Inflammation Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.; Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Dopazo+A%22">Dopazo A</searchLink>; Genomics Unit, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Sánchez-Cabo+F%22">Sánchez-Cabo F</searchLink>; Bioinformatics Unit, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Jalife+J%22">Jalife J</searchLink>; Cardiac Arrhythmia Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.; University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22de+la+Pompa+JL%22">de la Pompa JL</searchLink>; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.; Intercellular Signaling in Cardiovascular Development and Disease Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Filgueiras-Rama+D%22">Filgueiras-Rama D</searchLink>; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.; Novel Arrhythmogenic Mechanisms Program, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.; Cardiovascular Institute, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Muñoz-Cánoves+P%22">Muñoz-Cánoves P</searchLink>; Altos Labs, Inc., San Diego Institute of Science, San Diego, CA, USA. pmunozcanoves@altoslabs.com.; Tissue Regeneration Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain. pmunozcanoves@altoslabs.com.; Department of Experimental & Health Sciences, University Pompeu Fabra (UPF)/CIBERNED, Barcelona, Spain. pmunozcanoves@altoslabs.com.; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain. pmunozcanoves@altoslabs.com.<br /><searchLink fieldCode="AU" term="%22Redondo+JM%22">Redondo JM</searchLink>; Gene Regulation in Cardiovascular Remodelling and Inflammation Laboratory, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain. jmredondo@cbm.csic.es.; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. jmredondo@cbm.csic.es.; Cell-Cell Communication & Inflammation Unit, Centro de Biología Molecular Severo Ochoa (CBMSO), Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Madrid, Spain. jmredondo@cbm.csic.es.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2024 Oct 04; Vol. 15 (1), pp. 8602. <i>Date of Electronic Publication: </i>2024 Oct 04.
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