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Sex/gender effects of glial reactivity on preclinical Alzheimer's disease pathology.

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Title: Sex/gender effects of glial reactivity on preclinical Alzheimer's disease pathology.
Authors: Vila-Castelar C; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA., Akinci M; Barcelona Institute for Global Health, IS GLOBAL, Carrer del Dr. Aiguader, 88, Ciutat Vella, 08003, Barcelona, Spain.; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Carrer de Wellington, 30, 08005, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Carrer de Ramon Trias Fargas, 25, 27, Sant Marti, 08005, Barcelona, Spain., Palpatzis E; Barcelona Institute for Global Health, IS GLOBAL, Carrer del Dr. Aiguader, 88, Ciutat Vella, 08003, Barcelona, Spain.; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Carrer de Wellington, 30, 08005, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Carrer de Ramon Trias Fargas, 25, 27, Sant Marti, 08005, Barcelona, Spain., Aguilar-Dominguez P; Barcelona Institute for Global Health, IS GLOBAL, Carrer del Dr. Aiguader, 88, Ciutat Vella, 08003, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Carrer de Ramon Trias Fargas, 25, 27, Sant Marti, 08005, Barcelona, Spain., Operto G; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Carrer de Wellington, 30, 08005, Barcelona, Spain., Kollmorgen G; Roche Diagnostics GmbH, Nonnenwald 2, 82377, Penzberg, Germany., Quijano-Rubio C; Roche Diagnostics International Ltd, Forrenstrasse 2, 6343, Rotkreuz, Switzerland., Blennow K; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Wallinsgatan 6, 431 41, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Bla Straket 5, 413 45, Gothenburg, Sweden., Zetterberg H; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Wallinsgatan 6, 431 41, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Bla Straket 5, 413 45, Gothenburg, Sweden.; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, WC1N 3BG, London, UK.; UK Dementia Research Institute at UCL, Tottenham Ct Rd, W1T 7NF, London, UK.; Hong Kong Center for Neurodegenerative Diseases, Clear Water Bay, Hong Kong Science Park, Shatin, N.T., Hong Kong, China.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, 600 Highland Ave, J5/1 Mezzanine, Madison, WI, WI 53792, USA., Falcon C; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Carrer de Wellington, 30, 08005, Barcelona, Spain.; Hospital del Mar Medical Research Institute, Carrer del Dr. Aiguader, 88, Ciutat Vella, 08003, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Instituto de Salud Carlos III, Avenida Monforte de Lemos, 3-5, Pabellón 11, 28029, Madrid, Spain., Fauria K; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Carrer de Wellington, 30, 08005, Barcelona, Spain. kfauria@barcelonabeta.org., Gispert JD; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Carrer de Wellington, 30, 08005, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Carrer de Ramon Trias Fargas, 25, 27, Sant Marti, 08005, Barcelona, Spain.; Hospital del Mar Medical Research Institute, Carrer del Dr. Aiguader, 88, Ciutat Vella, 08003, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Instituto de Salud Carlos III, Avenida Monforte de Lemos, 3-5, Pabellón 11, 28029, Madrid, Spain., Grau-Rivera O; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Carrer de Wellington, 30, 08005, Barcelona, Spain.; Hospital del Mar Medical Research Institute, Carrer del Dr. Aiguader, 88, Ciutat Vella, 08003, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Avenida Monforte de Lemos, 3-5, Pabellón 11, 28029, Madrid, Spain.; Servei de Neurologia, Hospital del Mar, Passeig Marítim de la Barceloneta, 25, 29, Ciutat Vella, 08003, Barcelona, Spain., Suárez-Calvet M; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Carrer de Wellington, 30, 08005, Barcelona, Spain.; Hospital del Mar Medical Research Institute, Carrer del Dr. Aiguader, 88, Ciutat Vella, 08003, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Avenida Monforte de Lemos, 3-5, Pabellón 11, 28029, Madrid, Spain.; Servei de Neurologia, Hospital del Mar, Passeig Marítim de la Barceloneta, 25, 29, Ciutat Vella, 08003, Barcelona, Spain., Arenaza-Urquijo EM; Barcelona Institute for Global Health, IS GLOBAL, Carrer del Dr. Aiguader, 88, Ciutat Vella, 08003, Barcelona, Spain. eider.arenaza@isglobal.org.; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Carrer de Wellington, 30, 08005, Barcelona, Spain. eider.arenaza@isglobal.org.; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Avenida Monforte de Lemos, 3-5, Pabellón 11, 28029, Madrid, Spain. eider.arenaza@isglobal.org.
Corporate Authors: ALFA study
Source: Molecular psychiatry [Mol Psychiatry] 2025 Apr; Vol. 30 (4), pp. 1430-1439. Date of Electronic Publication: 2024 Oct 09.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Vila-Castelar+C%22">Vila-Castelar C</searchLink>; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.<br /><searchLink fieldCode="AU" term="%22Akinci+M%22">Akinci M</searchLink>; Barcelona Institute for Global Health, IS GLOBAL, Carrer del Dr. Aiguader, 88, Ciutat Vella, 08003, Barcelona, Spain.; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Carrer de Wellington, 30, 08005, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Carrer de Ramon Trias Fargas, 25, 27, Sant Marti, 08005, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Palpatzis+E%22">Palpatzis E</searchLink>; Barcelona Institute for Global Health, IS GLOBAL, Carrer del Dr. Aiguader, 88, Ciutat Vella, 08003, Barcelona, Spain.; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Carrer de Wellington, 30, 08005, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Carrer de Ramon Trias Fargas, 25, 27, Sant Marti, 08005, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Aguilar-Dominguez+P%22">Aguilar-Dominguez P</searchLink>; Barcelona Institute for Global Health, IS GLOBAL, Carrer del Dr. Aiguader, 88, Ciutat Vella, 08003, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Carrer de Ramon Trias Fargas, 25, 27, Sant Marti, 08005, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Operto+G%22">Operto G</searchLink>; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Carrer de Wellington, 30, 08005, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Kollmorgen+G%22">Kollmorgen G</searchLink>; Roche Diagnostics GmbH, Nonnenwald 2, 82377, Penzberg, Germany.<br /><searchLink fieldCode="AU" term="%22Quijano-Rubio+C%22">Quijano-Rubio C</searchLink>; Roche Diagnostics International Ltd, Forrenstrasse 2, 6343, Rotkreuz, Switzerland.<br /><searchLink fieldCode="AU" term="%22Blennow+K%22">Blennow K</searchLink>; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Wallinsgatan 6, 431 41, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Bla Straket 5, 413 45, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Zetterberg+H%22">Zetterberg H</searchLink>; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Wallinsgatan 6, 431 41, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Bla Straket 5, 413 45, Gothenburg, Sweden.; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, WC1N 3BG, London, UK.; UK Dementia Research Institute at UCL, Tottenham Ct Rd, W1T 7NF, London, UK.; Hong Kong Center for Neurodegenerative Diseases, Clear Water Bay, Hong Kong Science Park, Shatin, N.T., Hong Kong, China.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, 600 Highland Ave, J5/1 Mezzanine, Madison, WI, WI 53792, USA.<br /><searchLink fieldCode="AU" term="%22Falcon+C%22">Falcon C</searchLink>; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Carrer de Wellington, 30, 08005, Barcelona, Spain.; Hospital del Mar Medical Research Institute, Carrer del Dr. Aiguader, 88, Ciutat Vella, 08003, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Instituto de Salud Carlos III, Avenida Monforte de Lemos, 3-5, Pabellón 11, 28029, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Fauria+K%22">Fauria K</searchLink>; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Carrer de Wellington, 30, 08005, Barcelona, Spain. kfauria@barcelonabeta.org.<br /><searchLink fieldCode="AU" term="%22Gispert+JD%22">Gispert JD</searchLink>; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Carrer de Wellington, 30, 08005, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Carrer de Ramon Trias Fargas, 25, 27, Sant Marti, 08005, Barcelona, Spain.; Hospital del Mar Medical Research Institute, Carrer del Dr. Aiguader, 88, Ciutat Vella, 08003, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Instituto de Salud Carlos III, Avenida Monforte de Lemos, 3-5, Pabellón 11, 28029, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Grau-Rivera+O%22">Grau-Rivera O</searchLink>; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Carrer de Wellington, 30, 08005, Barcelona, Spain.; Hospital del Mar Medical Research Institute, Carrer del Dr. Aiguader, 88, Ciutat Vella, 08003, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Avenida Monforte de Lemos, 3-5, Pabellón 11, 28029, Madrid, Spain.; Servei de Neurologia, Hospital del Mar, Passeig Marítim de la Barceloneta, 25, 29, Ciutat Vella, 08003, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Suárez-Calvet+M%22">Suárez-Calvet M</searchLink>; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Carrer de Wellington, 30, 08005, Barcelona, Spain.; Hospital del Mar Medical Research Institute, Carrer del Dr. Aiguader, 88, Ciutat Vella, 08003, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Avenida Monforte de Lemos, 3-5, Pabellón 11, 28029, Madrid, Spain.; Servei de Neurologia, Hospital del Mar, Passeig Marítim de la Barceloneta, 25, 29, Ciutat Vella, 08003, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Arenaza-Urquijo+EM%22">Arenaza-Urquijo EM</searchLink>; Barcelona Institute for Global Health, IS GLOBAL, Carrer del Dr. Aiguader, 88, Ciutat Vella, 08003, Barcelona, Spain. eider.arenaza@isglobal.org.; Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Carrer de Wellington, 30, 08005, Barcelona, Spain. eider.arenaza@isglobal.org.; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Avenida Monforte de Lemos, 3-5, Pabellón 11, 28029, Madrid, Spain. eider.arenaza@isglobal.org.
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