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Ribosomal frameshifting selectively modulates the assembly, function, and pharmacological rescue of a misfolded CFTR variant.

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Title: Ribosomal frameshifting selectively modulates the assembly, function, and pharmacological rescue of a misfolded CFTR variant.
Authors: Carmody PJ; Department of Chemistry, Indiana University Bloomington, Bloomington, IN 47401., Roushar FJ; Department of Chemistry, Indiana University Bloomington, Bloomington, IN 47401., Tedman A; The James Tarpo Junior and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN 47907., Wang W; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233., Herwig M; Department of Chemistry, Vanderbilt University, Nashville, TN 37240., Kim M; Department of Chemistry, Vanderbilt University, Nashville, TN 37240.; Program in Chemical and Physical Biology, Vanderbilt University, Nashville, TN 37240., McDonald EF; Department of Chemistry, Vanderbilt University, Nashville, TN 37240., Noguera K; Department of Chemistry, Indiana University Bloomington, Bloomington, IN 47401., Wong-Roushar J; Department of Chemistry, Indiana University Bloomington, Bloomington, IN 47401., Poirier JL; Department of Chemistry, Indiana University Bloomington, Bloomington, IN 47401., Zelt NB; Department of Chemistry, Indiana University Bloomington, Bloomington, IN 47401., Pockrass BT; Department of Chemistry, Indiana University Bloomington, Bloomington, IN 47401., McKee AG; Department of Chemistry, Indiana University Bloomington, Bloomington, IN 47401., Kuntz CP; The James Tarpo Junior and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN 47907., Raju SV; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233., Plate L; Department of Chemistry, Vanderbilt University, Nashville, TN 37240.; Department of Biological Sciences, Vanderbilt University, Nashville, TN 37240., Penn WD; Department of Chemistry, Indiana University Bloomington, Bloomington, IN 47401., Schlebach JP; The James Tarpo Junior and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN 47907.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Oct 15; Vol. 121 (42), pp. e2414768121. Date of Electronic Publication: 2024 Oct 10.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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