View in EDS

Discovery of pyrazolo[1,5-a]pyrimidine derivatives targeting TLR4-TLR4∗ homodimerization via AI-powered next-generation screening.

Saved in:
Bibliographic Details
Title: Discovery of pyrazolo[1,5-a]pyrimidine derivatives targeting TLR4-TLR4∗ homodimerization via AI-powered next-generation screening.
Authors: Jiang YY; State Key Laboratory of Membrane Biology, School of Pharmaceutical Sciences, Tsinghua-Peking Center for Life Sciences, Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology (Ministry of Education), Tsinghua University, Beijing, 100084, China., Yan ST; State Key Laboratory of Membrane Biology, School of Pharmaceutical Sciences, Tsinghua-Peking Center for Life Sciences, Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology (Ministry of Education), Tsinghua University, Beijing, 100084, China., Zhang SZ; PaddleHelix Team, Baidu Inc., Shenzhen, 518000, China., Wang M; Toll Biotech Co., Ltd. (Beijing), Beijing, 102209, China., Diao WM; Toll Biotech Co., Ltd. (Beijing), Beijing, 102209, China., Li J; PaddleHelix Team, Baidu Inc., Shenzhen, 518000, China., Fang XM; PaddleHelix Team, Baidu Inc., Shenzhen, 518000, China., Yin H; State Key Laboratory of Membrane Biology, School of Pharmaceutical Sciences, Tsinghua-Peking Center for Life Sciences, Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology (Ministry of Education), Tsinghua University, Beijing, 100084, China. Electronic address: yin_hang@tsinghua.edu.cn.
Source: European journal of medicinal chemistry [Eur J Med Chem] 2024 Dec 15; Vol. 280, pp. 116945. Date of Electronic Publication: 2024 Oct 06.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 39388907
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Discovery of pyrazolo[1,5-a]pyrimidine derivatives targeting TLR4-TLR4∗ homodimerization via AI-powered next-generation screening.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Jiang+YY%22">Jiang YY</searchLink>; State Key Laboratory of Membrane Biology, School of Pharmaceutical Sciences, Tsinghua-Peking Center for Life Sciences, Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology (Ministry of Education), Tsinghua University, Beijing, 100084, China.<br /><searchLink fieldCode="AU" term="%22Yan+ST%22">Yan ST</searchLink>; State Key Laboratory of Membrane Biology, School of Pharmaceutical Sciences, Tsinghua-Peking Center for Life Sciences, Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology (Ministry of Education), Tsinghua University, Beijing, 100084, China.<br /><searchLink fieldCode="AU" term="%22Zhang+SZ%22">Zhang SZ</searchLink>; PaddleHelix Team, Baidu Inc., Shenzhen, 518000, China.<br /><searchLink fieldCode="AU" term="%22Wang+M%22">Wang M</searchLink>; Toll Biotech Co., Ltd. (Beijing), Beijing, 102209, China.<br /><searchLink fieldCode="AU" term="%22Diao+WM%22">Diao WM</searchLink>; Toll Biotech Co., Ltd. (Beijing), Beijing, 102209, China.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; PaddleHelix Team, Baidu Inc., Shenzhen, 518000, China.<br /><searchLink fieldCode="AU" term="%22Fang+XM%22">Fang XM</searchLink>; PaddleHelix Team, Baidu Inc., Shenzhen, 518000, China.<br /><searchLink fieldCode="AU" term="%22Yin+H%22">Yin H</searchLink>; State Key Laboratory of Membrane Biology, School of Pharmaceutical Sciences, Tsinghua-Peking Center for Life Sciences, Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology (Ministry of Education), Tsinghua University, Beijing, 100084, China. Electronic address: yin_hang@tsinghua.edu.cn.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%220420510%22">European journal of medicinal chemistry</searchLink> [Eur J Med Chem] 2024 Dec 15; Vol. 280, pp. 116945. <i>Date of Electronic Publication: </i>2024 Oct 06.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Editions+Scientifiques+Elsevier%22">Editions Scientifiques Elsevier </searchLink><i>Country of Publication: </i>France <i>NLM ID: </i>0420510 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1768-3254 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202235234%22">02235234 </searchLink><i>NLM ISO Abbreviation: </i>Eur J Med Chem <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=39388907
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.ejmech.2024.116945
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 116945
    Titles:
      – TitleFull: Discovery of pyrazolo[1,5-a]pyrimidine derivatives targeting TLR4-TLR4∗ homodimerization via AI-powered next-generation screening.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Jiang YY
      – PersonEntity:
          Name:
            NameFull: Yan ST
      – PersonEntity:
          Name:
            NameFull: Zhang SZ
      – PersonEntity:
          Name:
            NameFull: Wang M
      – PersonEntity:
          Name:
            NameFull: Diao WM
      – PersonEntity:
          Name:
            NameFull: Li J
      – PersonEntity:
          Name:
            NameFull: Fang XM
      – PersonEntity:
          Name:
            NameFull: Yin H
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 15
              M: 12
              Text: 2024 Dec 15
              Type: published
              Y: 2024
          Identifiers:
            – Type: issn-electronic
              Value: 1768-3254
          Numbering:
            – Type: volume
              Value: 280
          Titles:
            – TitleFull: European journal of medicinal chemistry
              Type: main
ResultId 1