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Targeted delivery of napabucasin with radiotherapy improves outcomes in diffuse midline glioma.

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Title: Targeted delivery of napabucasin with radiotherapy improves outcomes in diffuse midline glioma.
Authors: Gallitto M; Herbert Irving Comprehensive Cancer Center, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, New York, USA.; Department of Radiation Oncology, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, New York, USA., Zhang X; Department of Genetics and Development, Institute for Cancer Genetics, Columbia University Irving Medical Center, New York, New York, USA., De Los Santos G; Department of Radiation Oncology, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, New York, USA., Wei HJ; Fralin Biomedical Research Institute, Virginia Polytechnic Institute and State University, Roanoke, 24016, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, New York, USA.; Department of Radiation Oncology, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, New York, USA., Fernández EC; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA.; Department of Systems Biology, Columbia University Irving Medical Center, New York, New York, USA.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA., Duan S; Department of Genetics and Development, Institute for Cancer Genetics, Columbia University Irving Medical Center, New York, New York, USA.; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China., Sedor G; Herbert Irving Comprehensive Cancer Center, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, New York, USA.; Department of Radiation Oncology, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, New York, USA., Yoh N; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, New York, USA., Kokossis D; Department of Radiation Oncology, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, New York, USA., Angel JC; Department of Molecular Pharmacology and Therapeutics, Columbia University, New York, New York, USA.; Department of Biomedical Informatics, Columbia University, New York, New York, USA., Wang YF; Department of Radiation Oncology, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, New York, USA., White E; Department of Systems Biology, Columbia University Irving Medical Center, New York, New York, USA., Kinslow CJ; Herbert Irving Comprehensive Cancer Center, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, New York, USA.; Department of Radiation Oncology, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, New York, USA., Berg X; Department of Radiation Oncology, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, New York, USA., Tomassoni L; Department of Systems Biology, Columbia University Irving Medical Center, New York, New York, USA.; DarwinHealth Inc., New York, NYUSA., Zandkarimi F; Department of Chemistry, Columbia University, New York, New York, USA., Chio IIC; Department of Genetics and Development, Institute for Cancer Genetics, Columbia University Irving Medical Center, New York, New York, USA., Canoll P; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA.; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, New York, USA., Bruce JN; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, New York, USA., Feldstein NA; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, New York, USA., Gartrell RD; Department of Pediatrics, Columbia University Irving Medical Center, New York, New York, USA.; Division of Pediatric Oncology, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Cheng SK; Herbert Irving Comprehensive Cancer Center, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, New York, USA.; Department of Radiation Oncology, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, New York, USA., Garvin JH; Department of Pediatrics, Columbia University Irving Medical Center, New York, New York, USA., Zacharoulis S; Department of Pediatrics, Columbia University Irving Medical Center, New York, New York, USA., Wechsler-Reya RJ; Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, New York, USA., Pavisic J; Department of Pediatrics, Columbia University Irving Medical Center, New York, New York, USA.; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Califano A; Chan Zuckerberg Biohub New York, New York, New York, USA.; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, USA.; Department of Medicine, Columbia University, New York, New YorkUSA.; Department of Biomedical Informatics, Columbia University, New York, New York, USA.; Department of Systems Biology, Columbia University Irving Medical Center, New York, New York, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, New York, USA., Zhang Z; Department of Genetics and Development, Institute for Cancer Genetics, Columbia University Irving Medical Center, New York, New York, USA., Wu CC; Fralin Biomedical Research Institute, Virginia Polytechnic Institute and State University, Roanoke, 24016, USA.; Department of Internal Medicine, Virginia Tech Carilion School of Medicine, Roanoke, 24016, USA.; Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, 24061, USA.; The Brain Tumor Institute, Children's National Hospital, Washington, 20010, USA.; Center for Cancer and Immunology Research, Children's National Hospital, Washington, 20010, USA.
Source: Neuro-oncology [Neuro Oncol] 2025 Mar 07; Vol. 27 (3), pp. 795-810.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 100887420 Publication Model: Print Cited Medium: Internet ISSN: 1523-5866 (Electronic) Linking ISSN: 15228517 NLM ISO Abbreviation: Neuro Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Targeted delivery of napabucasin with radiotherapy improves outcomes in diffuse midline glioma.
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  Data: <searchLink fieldCode="AU" term="%22Gallitto+M%22">Gallitto M</searchLink>; Herbert Irving Comprehensive Cancer Center, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, New York, USA.; Department of Radiation Oncology, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Department of Genetics and Development, Institute for Cancer Genetics, Columbia University Irving Medical Center, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22De+Los+Santos+G%22">De Los Santos G</searchLink>; Department of Radiation Oncology, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Wei+HJ%22">Wei HJ</searchLink>; Fralin Biomedical Research Institute, Virginia Polytechnic Institute and State University, Roanoke, 24016, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, New York, USA.; Department of Radiation Oncology, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Fernández+EC%22">Fernández EC</searchLink>; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA.; Department of Systems Biology, Columbia University Irving Medical Center, New York, New York, USA.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Duan+S%22">Duan S</searchLink>; Department of Genetics and Development, Institute for Cancer Genetics, Columbia University Irving Medical Center, New York, New York, USA.; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.<br /><searchLink fieldCode="AU" term="%22Sedor+G%22">Sedor G</searchLink>; Herbert Irving Comprehensive Cancer Center, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, New York, USA.; Department of Radiation Oncology, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Yoh+N%22">Yoh N</searchLink>; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Kokossis+D%22">Kokossis D</searchLink>; Department of Radiation Oncology, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Angel+JC%22">Angel JC</searchLink>; Department of Molecular Pharmacology and Therapeutics, Columbia University, New York, New York, USA.; Department of Biomedical Informatics, Columbia University, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Wang+YF%22">Wang YF</searchLink>; Department of Radiation Oncology, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22White+E%22">White E</searchLink>; Department of Systems Biology, Columbia University Irving Medical Center, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Kinslow+CJ%22">Kinslow CJ</searchLink>; Herbert Irving Comprehensive Cancer Center, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, New York, USA.; Department of Radiation Oncology, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Berg+X%22">Berg X</searchLink>; Department of Radiation Oncology, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Tomassoni+L%22">Tomassoni L</searchLink>; Department of Systems Biology, Columbia University Irving Medical Center, New York, New York, USA.; DarwinHealth Inc., New York, NYUSA.<br /><searchLink fieldCode="AU" term="%22Zandkarimi+F%22">Zandkarimi F</searchLink>; Department of Chemistry, Columbia University, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Chio+IIC%22">Chio IIC</searchLink>; Department of Genetics and Development, Institute for Cancer Genetics, Columbia University Irving Medical Center, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Canoll+P%22">Canoll P</searchLink>; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA.; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Bruce+JN%22">Bruce JN</searchLink>; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Feldstein+NA%22">Feldstein NA</searchLink>; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Gartrell+RD%22">Gartrell RD</searchLink>; Department of Pediatrics, Columbia University Irving Medical Center, New York, New York, USA.; Division of Pediatric Oncology, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Cheng+SK%22">Cheng SK</searchLink>; Herbert Irving Comprehensive Cancer Center, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, New York, USA.; Department of Radiation Oncology, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Garvin+JH%22">Garvin JH</searchLink>; Department of Pediatrics, Columbia University Irving Medical Center, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Zacharoulis+S%22">Zacharoulis S</searchLink>; Department of Pediatrics, Columbia University Irving Medical Center, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Wechsler-Reya+RJ%22">Wechsler-Reya RJ</searchLink>; Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Pavisic+J%22">Pavisic J</searchLink>; Department of Pediatrics, Columbia University Irving Medical Center, New York, New York, USA.; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Califano+A%22">Califano A</searchLink>; Chan Zuckerberg Biohub New York, New York, New York, USA.; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, USA.; Department of Medicine, Columbia University, New York, New YorkUSA.; Department of Biomedical Informatics, Columbia University, New York, New York, USA.; Department of Systems Biology, Columbia University Irving Medical Center, New York, New York, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Department of Genetics and Development, Institute for Cancer Genetics, Columbia University Irving Medical Center, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Wu+CC%22">Wu CC</searchLink>; Fralin Biomedical Research Institute, Virginia Polytechnic Institute and State University, Roanoke, 24016, USA.; Department of Internal Medicine, Virginia Tech Carilion School of Medicine, Roanoke, 24016, USA.; Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, 24061, USA.; The Brain Tumor Institute, Children's National Hospital, Washington, 20010, USA.; Center for Cancer and Immunology Research, Children's National Hospital, Washington, 20010, USA.
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