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Knockdown of ketohexokinase versus inhibition of its kinase activity exert divergent effects on fructose metabolism.

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Title: Knockdown of ketohexokinase versus inhibition of its kinase activity exert divergent effects on fructose metabolism.
Authors: Park SH; Department of Pediatrics and Division of Pediatric Gastroenterology and., Fadhul T; Department of Pediatrics and Division of Pediatric Gastroenterology and., Conroy LR; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, USA., Clarke HA; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, USA.; Department of Biochemistry & Molecular Biology, Center for Advanced Spatial Biomolecule Research, University of Florida, Gainesville, Florida, USA., Sun RC; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, USA.; Department of Biochemistry & Molecular Biology, Center for Advanced Spatial Biomolecule Research, University of Florida, Gainesville, Florida, USA., Wallenius K; Bioscience, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Boucher J; Bioscience, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.; The Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., O'Mahony G; Medicinal Chemistry and., Boianelli A; DMPK, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Persson M; DMPK, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Jung S; Department of Biological Chemistry, School of Medicine; and Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California, Irvine, Irvine, California, USA., Jang C; Department of Biological Chemistry, School of Medicine; and Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California, Irvine, Irvine, California, USA., Loria AS; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA., Martinez GJ; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA., Kipp ZA; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA., Bates EA; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA., Hinds TD Jr; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA., Divanovic S; Department of Pediatrics, University of Cincinnati College of Medicine; and Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Softic S; Department of Pediatrics and Division of Pediatric Gastroenterology and.; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA.; Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Source: JCI insight [JCI Insight] 2024 Dec 06; Vol. 9 (23). Date of Electronic Publication: 2024 Dec 06.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Knockdown of ketohexokinase versus inhibition of its kinase activity exert divergent effects on fructose metabolism.
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  Data: <searchLink fieldCode="AU" term="%22Park+SH%22">Park SH</searchLink>; Department of Pediatrics and Division of Pediatric Gastroenterology and.<br /><searchLink fieldCode="AU" term="%22Fadhul+T%22">Fadhul T</searchLink>; Department of Pediatrics and Division of Pediatric Gastroenterology and.<br /><searchLink fieldCode="AU" term="%22Conroy+LR%22">Conroy LR</searchLink>; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, USA.<br /><searchLink fieldCode="AU" term="%22Clarke+HA%22">Clarke HA</searchLink>; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, USA.; Department of Biochemistry & Molecular Biology, Center for Advanced Spatial Biomolecule Research, University of Florida, Gainesville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Sun+RC%22">Sun RC</searchLink>; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, USA.; Department of Biochemistry & Molecular Biology, Center for Advanced Spatial Biomolecule Research, University of Florida, Gainesville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Wallenius+K%22">Wallenius K</searchLink>; Bioscience, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Boucher+J%22">Boucher J</searchLink>; Bioscience, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.; The Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22O'Mahony+G%22">O'Mahony G</searchLink>; Medicinal Chemistry and.<br /><searchLink fieldCode="AU" term="%22Boianelli+A%22">Boianelli A</searchLink>; DMPK, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Persson+M%22">Persson M</searchLink>; DMPK, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Jung+S%22">Jung S</searchLink>; Department of Biological Chemistry, School of Medicine; and Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California, Irvine, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Jang+C%22">Jang C</searchLink>; Department of Biological Chemistry, School of Medicine; and Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California, Irvine, Irvine, California, USA.<br /><searchLink fieldCode="AU" term="%22Loria+AS%22">Loria AS</searchLink>; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA.<br /><searchLink fieldCode="AU" term="%22Martinez+GJ%22">Martinez GJ</searchLink>; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA.<br /><searchLink fieldCode="AU" term="%22Kipp+ZA%22">Kipp ZA</searchLink>; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA.<br /><searchLink fieldCode="AU" term="%22Bates+EA%22">Bates EA</searchLink>; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA.<br /><searchLink fieldCode="AU" term="%22Hinds+TD+Jr%22">Hinds TD Jr</searchLink>; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA.<br /><searchLink fieldCode="AU" term="%22Divanovic+S%22">Divanovic S</searchLink>; Department of Pediatrics, University of Cincinnati College of Medicine; and Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Softic+S%22">Softic S</searchLink>; Department of Pediatrics and Division of Pediatric Gastroenterology and.; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA.; Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
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  Data: <searchLink fieldCode="JN" term="%22101676073%22">JCI insight</searchLink> [JCI Insight] 2024 Dec 06; Vol. 9 (23). <i>Date of Electronic Publication: </i>2024 Dec 06.
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        Value: 10.1172/jci.insight.184396
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              Text: 2024 Dec 06
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