Knockdown of ketohexokinase versus inhibition of its kinase activity exert divergent effects on fructose metabolism.

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Title: Knockdown of ketohexokinase versus inhibition of its kinase activity exert divergent effects on fructose metabolism.
Authors: Park SH; Department of Pediatrics and Division of Pediatric Gastroenterology and., Fadhul T; Department of Pediatrics and Division of Pediatric Gastroenterology and., Conroy LR; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, USA., Clarke HA; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, USA.; Department of Biochemistry & Molecular Biology, Center for Advanced Spatial Biomolecule Research, University of Florida, Gainesville, Florida, USA., Sun RC; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, USA.; Department of Biochemistry & Molecular Biology, Center for Advanced Spatial Biomolecule Research, University of Florida, Gainesville, Florida, USA., Wallenius K; Bioscience, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Boucher J; Bioscience, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.; The Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., O'Mahony G; Medicinal Chemistry and., Boianelli A; DMPK, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Persson M; DMPK, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Jung S; Department of Biological Chemistry, School of Medicine; and Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California, Irvine, Irvine, California, USA., Jang C; Department of Biological Chemistry, School of Medicine; and Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California, Irvine, Irvine, California, USA., Loria AS; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA., Martinez GJ; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA., Kipp ZA; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA., Bates EA; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA., Hinds TD Jr; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA., Divanovic S; Department of Pediatrics, University of Cincinnati College of Medicine; and Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Softic S; Department of Pediatrics and Division of Pediatric Gastroenterology and.; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA.; Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Source: JCI insight [JCI Insight] 2024 Dec 06; Vol. 9 (23). Date of Electronic Publication: 2024 Dec 06.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2379-3708
DOI:10.1172/jci.insight.184396