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Efficacy and safety of a novel low-dose triple single-pill combination of telmisartan, amlodipine and indapamide, compared with dual combinations for treatment of hypertension: a randomised, double-blind, active-controlled, international clinical trial.

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Title: Efficacy and safety of a novel low-dose triple single-pill combination of telmisartan, amlodipine and indapamide, compared with dual combinations for treatment of hypertension: a randomised, double-blind, active-controlled, international clinical trial.
Authors: Rodgers A; The George Institute for Global Health, University of New South Wales, Barangaroo, NSW, Australia; Imperial College London, London, UK. Electronic address: arodgers@georgeinstitute.org., Salam A; The George Institute for Global Health, University of New South Wales, Barangaroo, NSW, Australia; Prasanna School of Public Health, Manipal Academy of Higher Education, Manipal, India., Schutte AE; The George Institute for Global Health, University of New South Wales, Barangaroo, NSW, Australia., Cushman WC; University of Tennessee Health Science Center, Memphis, TN, USA., de Silva HA; Clinical Trials Unit, Faculty of Medicine, University of Kelaniya, Kelaniya, Sri Lanka., Di Tanna GL; University of Applied Sciences and Arts of Southern Switzerland, Manno, Switzerland., Grobbee DE; Julius Global Health, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands., Narkiewicz K; Medical University of Gdańsk, Gdańsk, Poland., Ojji DB; University of Abuja, Abuja, Nigeria., Poulter NR; Imperial College London, London, UK., Schlaich MP; The University of Western Australia, Perth, WA, Australia., Oparil S; University of Alabama at Birmingham, Birmingham, AL, USA., Spiering W; Department of Vascular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands., Williams B; University College London, London, UK., Wright JT Jr; University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, OH, USA., Lakshman P; Jaffna Teaching Hospital, Jaffna, Sri Lanka., Uluwattage W; Karapitiya Teaching Hospital, Galle, Sri Lanka., Hay P; Castle Hill Medical Centre, Sydney, NSW, Australia., Pereira T; Colombo South Teaching Hospital, Kalubowila, Sri Lanka., Amarasena N; Teaching Hospital Sri Jayawardenapura, Sri Jayawardenapura, Sri Lanka., Ranasinghe G; Cardiology Institute, National Hospital, Colombo, Sri Lanka., Gianacas C; The George Institute for Global Health, University of New South Wales, Barangaroo, NSW, Australia., Shanthakumar M; The George Institute for Global Health, University of New South Wales, Barangaroo, NSW, Australia., Liu X; The George Institute for Global Health, University of New South Wales, Barangaroo, NSW, Australia., Wang N; The George Institute for Global Health, University of New South Wales, Barangaroo, NSW, Australia., Gnanenthiran SR; The George Institute for Global Health, University of New South Wales, Barangaroo, NSW, Australia., Whelton PK; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
Corporate Authors: GMRx2 Investigators
Source: Lancet (London, England) [Lancet] 2024 Oct 19; Vol. 404 (10462), pp. 1536-1546.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study; Comparative Study; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 2985213R Publication Model: Print Cited Medium: Internet ISSN: 1474-547X (Electronic) Linking ISSN: 01406736 NLM ISO Abbreviation: Lancet Subsets: MEDLINE
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  Data: Efficacy and safety of a novel low-dose triple single-pill combination of telmisartan, amlodipine and indapamide, compared with dual combinations for treatment of hypertension: a randomised, double-blind, active-controlled, international clinical trial.
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  Data: <searchLink fieldCode="AU" term="%22Rodgers+A%22">Rodgers A</searchLink>; The George Institute for Global Health, University of New South Wales, Barangaroo, NSW, Australia; Imperial College London, London, UK. Electronic address: arodgers@georgeinstitute.org.<br /><searchLink fieldCode="AU" term="%22Salam+A%22">Salam A</searchLink>; The George Institute for Global Health, University of New South Wales, Barangaroo, NSW, Australia; Prasanna School of Public Health, Manipal Academy of Higher Education, Manipal, India.<br /><searchLink fieldCode="AU" term="%22Schutte+AE%22">Schutte AE</searchLink>; The George Institute for Global Health, University of New South Wales, Barangaroo, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Cushman+WC%22">Cushman WC</searchLink>; University of Tennessee Health Science Center, Memphis, TN, USA.<br /><searchLink fieldCode="AU" term="%22de+Silva+HA%22">de Silva HA</searchLink>; Clinical Trials Unit, Faculty of Medicine, University of Kelaniya, Kelaniya, Sri Lanka.<br /><searchLink fieldCode="AU" term="%22Di+Tanna+GL%22">Di Tanna GL</searchLink>; University of Applied Sciences and Arts of Southern Switzerland, Manno, Switzerland.<br /><searchLink fieldCode="AU" term="%22Grobbee+DE%22">Grobbee DE</searchLink>; Julius Global Health, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Narkiewicz+K%22">Narkiewicz K</searchLink>; Medical University of Gdańsk, Gdańsk, Poland.<br /><searchLink fieldCode="AU" term="%22Ojji+DB%22">Ojji DB</searchLink>; University of Abuja, Abuja, Nigeria.<br /><searchLink fieldCode="AU" term="%22Poulter+NR%22">Poulter NR</searchLink>; Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Schlaich+MP%22">Schlaich MP</searchLink>; The University of Western Australia, Perth, WA, Australia.<br /><searchLink fieldCode="AU" term="%22Oparil+S%22">Oparil S</searchLink>; University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Spiering+W%22">Spiering W</searchLink>; Department of Vascular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Williams+B%22">Williams B</searchLink>; University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Wright+JT+Jr%22">Wright JT Jr</searchLink>; University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Lakshman+P%22">Lakshman P</searchLink>; Jaffna Teaching Hospital, Jaffna, Sri Lanka.<br /><searchLink fieldCode="AU" term="%22Uluwattage+W%22">Uluwattage W</searchLink>; Karapitiya Teaching Hospital, Galle, Sri Lanka.<br /><searchLink fieldCode="AU" term="%22Hay+P%22">Hay P</searchLink>; Castle Hill Medical Centre, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Pereira+T%22">Pereira T</searchLink>; Colombo South Teaching Hospital, Kalubowila, Sri Lanka.<br /><searchLink fieldCode="AU" term="%22Amarasena+N%22">Amarasena N</searchLink>; Teaching Hospital Sri Jayawardenapura, Sri Jayawardenapura, Sri Lanka.<br /><searchLink fieldCode="AU" term="%22Ranasinghe+G%22">Ranasinghe G</searchLink>; Cardiology Institute, National Hospital, Colombo, Sri Lanka.<br /><searchLink fieldCode="AU" term="%22Gianacas+C%22">Gianacas C</searchLink>; The George Institute for Global Health, University of New South Wales, Barangaroo, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Shanthakumar+M%22">Shanthakumar M</searchLink>; The George Institute for Global Health, University of New South Wales, Barangaroo, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; The George Institute for Global Health, University of New South Wales, Barangaroo, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Wang+N%22">Wang N</searchLink>; The George Institute for Global Health, University of New South Wales, Barangaroo, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Gnanenthiran+SR%22">Gnanenthiran SR</searchLink>; The George Institute for Global Health, University of New South Wales, Barangaroo, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Whelton+PK%22">Whelton PK</searchLink>; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
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