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CHF6523 data suggest that the phosphoinositide 3-kinase delta isoform is not a suitable target for the management of COPD.

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Title: CHF6523 data suggest that the phosphoinositide 3-kinase delta isoform is not a suitable target for the management of COPD.
Authors: Govoni M; Chiesi Farmaceutici SpA, Parma, Italy. m.govoni@chiesi.com., Bassi M; Chiesi Farmaceutici SpA, Parma, Italy., Girardello L; Alira Health Srl, Milan, Italy., Lucci G; Chiesi Farmaceutici SpA, Parma, Italy., Rony F; Chiesi SAS, Bois Colombes, France., Charretier R; Chiesi SAS, Bois Colombes, France., Galkin D; Chiesi USA, Inc, Cary, NC, USA., Faietti ML; Chiesi Farmaceutici SpA, Parma, Italy., Pioselli B; Chiesi Farmaceutici SpA, Parma, Italy., Modafferi G; Chiesi Farmaceutici SpA, Parma, Italy., Benfeitas R; Chiesi Pharma AB, Stockholm, Sweden., Bonatti M; Chiesi Farmaceutici SpA, Parma, Italy.; Respiratory Medicine Unit, Department of Medicine Solna and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden., Miglietta D; Chiesi Farmaceutici SpA, Parma, Italy., Clark J; Biological Chemistry, Babraham Institute, Cambridge, UK., Pedersen F; Velocity Clinical Research Grosshansdorf, Formerly Known as Pulmonary Research Institute at LungenClinic Grosshansdorf, Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Grosshansdorf, Germany., Kirsten AM; Velocity Clinical Research Grosshansdorf, Formerly Known as Pulmonary Research Institute at LungenClinic Grosshansdorf, Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Grosshansdorf, Germany., Beeh KM; insaf Respiratory Research Institute, Wiesbaden, Germany., Kornmann O; IKF Pneumologie Frankfurt, Clinical Research Centre Respiratory Diseases, Frankfurt, Germany., Korn S; IKF Pneumologie Mainz, Mainz, Germany.; Thoraxklinik Heidelberg, Heidelberg, Germany., Ludwig-Sengpiel A; Velocity Clinical Research Lübeck GmbH, Formerly Known as KLB Health Research, Lübeck, Germany., Watz H; Velocity Clinical Research Grosshansdorf, Formerly Known as Pulmonary Research Institute at LungenClinic Grosshansdorf, Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Grosshansdorf, Germany.
Source: Respiratory research [Respir Res] 2024 Oct 19; Vol. 25 (1), pp. 380. Date of Electronic Publication: 2024 Oct 19.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101090633 Publication Model: Electronic Cited Medium: Internet ISSN: 1465-993X (Electronic) Linking ISSN: 14659921 NLM ISO Abbreviation: Respir Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: CHF6523 data suggest that the phosphoinositide 3-kinase delta isoform is not a suitable target for the management of COPD.
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  Data: <searchLink fieldCode="AU" term="%22Govoni+M%22">Govoni M</searchLink>; Chiesi Farmaceutici SpA, Parma, Italy. m.govoni@chiesi.com.<br /><searchLink fieldCode="AU" term="%22Bassi+M%22">Bassi M</searchLink>; Chiesi Farmaceutici SpA, Parma, Italy.<br /><searchLink fieldCode="AU" term="%22Girardello+L%22">Girardello L</searchLink>; Alira Health Srl, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Lucci+G%22">Lucci G</searchLink>; Chiesi Farmaceutici SpA, Parma, Italy.<br /><searchLink fieldCode="AU" term="%22Rony+F%22">Rony F</searchLink>; Chiesi SAS, Bois Colombes, France.<br /><searchLink fieldCode="AU" term="%22Charretier+R%22">Charretier R</searchLink>; Chiesi SAS, Bois Colombes, France.<br /><searchLink fieldCode="AU" term="%22Galkin+D%22">Galkin D</searchLink>; Chiesi USA, Inc, Cary, NC, USA.<br /><searchLink fieldCode="AU" term="%22Faietti+ML%22">Faietti ML</searchLink>; Chiesi Farmaceutici SpA, Parma, Italy.<br /><searchLink fieldCode="AU" term="%22Pioselli+B%22">Pioselli B</searchLink>; Chiesi Farmaceutici SpA, Parma, Italy.<br /><searchLink fieldCode="AU" term="%22Modafferi+G%22">Modafferi G</searchLink>; Chiesi Farmaceutici SpA, Parma, Italy.<br /><searchLink fieldCode="AU" term="%22Benfeitas+R%22">Benfeitas R</searchLink>; Chiesi Pharma AB, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Bonatti+M%22">Bonatti M</searchLink>; Chiesi Farmaceutici SpA, Parma, Italy.; Respiratory Medicine Unit, Department of Medicine Solna and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Miglietta+D%22">Miglietta D</searchLink>; Chiesi Farmaceutici SpA, Parma, Italy.<br /><searchLink fieldCode="AU" term="%22Clark+J%22">Clark J</searchLink>; Biological Chemistry, Babraham Institute, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Pedersen+F%22">Pedersen F</searchLink>; Velocity Clinical Research Grosshansdorf, Formerly Known as Pulmonary Research Institute at LungenClinic Grosshansdorf, Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Grosshansdorf, Germany.<br /><searchLink fieldCode="AU" term="%22Kirsten+AM%22">Kirsten AM</searchLink>; Velocity Clinical Research Grosshansdorf, Formerly Known as Pulmonary Research Institute at LungenClinic Grosshansdorf, Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Grosshansdorf, Germany.<br /><searchLink fieldCode="AU" term="%22Beeh+KM%22">Beeh KM</searchLink>; insaf Respiratory Research Institute, Wiesbaden, Germany.<br /><searchLink fieldCode="AU" term="%22Kornmann+O%22">Kornmann O</searchLink>; IKF Pneumologie Frankfurt, Clinical Research Centre Respiratory Diseases, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Korn+S%22">Korn S</searchLink>; IKF Pneumologie Mainz, Mainz, Germany.; Thoraxklinik Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Ludwig-Sengpiel+A%22">Ludwig-Sengpiel A</searchLink>; Velocity Clinical Research Lübeck GmbH, Formerly Known as KLB Health Research, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Watz+H%22">Watz H</searchLink>; Velocity Clinical Research Grosshansdorf, Formerly Known as Pulmonary Research Institute at LungenClinic Grosshansdorf, Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Grosshansdorf, Germany.
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  Data: <searchLink fieldCode="JN" term="%22101090633%22">Respiratory research</searchLink> [Respir Res] 2024 Oct 19; Vol. 25 (1), pp. 380. <i>Date of Electronic Publication: </i>2024 Oct 19.
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  Data: Journal Article; Randomized Controlled Trial; Multicenter Study
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central+Ltd%22">BioMed Central Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101090633 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1465-993X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214659921%22">14659921 </searchLink><i>NLM ISO Abbreviation: </i>Respir Res <i>Subsets: </i>MEDLINE
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