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Diacerein reduces inflammasome activation and SARS-CoV-2 virus replication: a proof-of-concept translational study.

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Title: Diacerein reduces inflammasome activation and SARS-CoV-2 virus replication: a proof-of-concept translational study.
Authors: Carmo HRP; Laboratory of Vascular Biology and Atherosclerosis (Aterolab), State University of Campinas (UNICAMP), Campinas, Brazil., Castillo AR; Laboratory of Vascular Biology and Atherosclerosis (Aterolab), State University of Campinas (UNICAMP), Campinas, Brazil., Bonilha I; Laboratory of Vascular Biology and Atherosclerosis (Aterolab), State University of Campinas (UNICAMP), Campinas, Brazil., Gomes EIL; Laboratory of Vascular Biology and Atherosclerosis (Aterolab), State University of Campinas (UNICAMP), Campinas, Brazil., Barreto J; Laboratory of Vascular Biology and Atherosclerosis (Aterolab), State University of Campinas (UNICAMP), Campinas, Brazil., Moura FA; Brigham and Women's Hospital, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States., Davanzo GG; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil., de Brito Monteiro L; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil., Muraro SP; Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil., Fabiano de Souza G; Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil., Morari J; Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas (UNICAMP), Campinas, Brazil., Galdino FE; Institute of Chemistry, University of Campinas (UNICAMP), Campinas, Brazil.; Brazilian Synchrotron Light Laboratory (LNLS), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, Brazil., Brunetti NS; Autoimmune Research Laboratory, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil., Reis-de-Oliveira G; Laboratory of Neuroproteomics, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil., Carregari VC; Laboratory of Neuroproteomics, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil., Nadruz W; Laboratory of Vascular Biology and Atherosclerosis (Aterolab), State University of Campinas (UNICAMP), Campinas, Brazil., Martins-de-Souza D; Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas (UNICAMP), Campinas, Brazil.; Laboratory of Neuroproteomics, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil.; D'Or Institute for Research and Education (IDOR), São Paulo, Brazil.; Experimental Medicine Research Cluster (EMRC), University of Campinas (UNICAMP), Campinas, Brazil., Farias AS; Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas (UNICAMP), Campinas, Brazil.; Autoimmune Research Laboratory, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil.; Experimental Medicine Research Cluster (EMRC), University of Campinas (UNICAMP), Campinas, Brazil., Velloso LA; Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas (UNICAMP), Campinas, Brazil., Proenca-Modena JL; Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil.; Experimental Medicine Research Cluster (EMRC), University of Campinas (UNICAMP), Campinas, Brazil., Mori MA; Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas (UNICAMP), Campinas, Brazil.; Experimental Medicine Research Cluster (EMRC), University of Campinas (UNICAMP), Campinas, Brazil.; Laboratory of Aging Biology, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, Brazil., Loh W; Institute of Chemistry, University of Campinas (UNICAMP), Campinas, Brazil., Bhatt DL; Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY, United States., Yellon DM; The Hatter Cardiovascular Institute, University College London, London, United Kingdom., Davidson SM; The Hatter Cardiovascular Institute, University College London, London, United Kingdom., De Oliveira PG; Instituto de Ortopedia e Traumatologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, Brazil.; Sport Traumatology Group, Department of Orthopaedics and Traumatology, Santa Casa de São Paulo School of Medical Sciences, São Paulo, Brazil., Moraes-Vieira PM; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil.; Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas (UNICAMP), Campinas, Brazil.; Experimental Medicine Research Cluster (EMRC), University of Campinas (UNICAMP), Campinas, Brazil., Sposito AC; Laboratory of Vascular Biology and Atherosclerosis (Aterolab), State University of Campinas (UNICAMP), Campinas, Brazil.
Source: Frontiers in pharmacology [Front Pharmacol] 2024 Oct 07; Vol. 15, pp. 1402032. Date of Electronic Publication: 2024 Oct 07 (Print Publication: 2024).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE
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  Data: Diacerein reduces inflammasome activation and SARS-CoV-2 virus replication: a proof-of-concept translational study.
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  Data: <searchLink fieldCode="AU" term="%22Carmo+HRP%22">Carmo HRP</searchLink>; Laboratory of Vascular Biology and Atherosclerosis (Aterolab), State University of Campinas (UNICAMP), Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Castillo+AR%22">Castillo AR</searchLink>; Laboratory of Vascular Biology and Atherosclerosis (Aterolab), State University of Campinas (UNICAMP), Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Bonilha+I%22">Bonilha I</searchLink>; Laboratory of Vascular Biology and Atherosclerosis (Aterolab), State University of Campinas (UNICAMP), Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Gomes+EIL%22">Gomes EIL</searchLink>; Laboratory of Vascular Biology and Atherosclerosis (Aterolab), State University of Campinas (UNICAMP), Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Barreto+J%22">Barreto J</searchLink>; Laboratory of Vascular Biology and Atherosclerosis (Aterolab), State University of Campinas (UNICAMP), Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Moura+FA%22">Moura FA</searchLink>; Brigham and Women's Hospital, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.<br /><searchLink fieldCode="AU" term="%22Davanzo+GG%22">Davanzo GG</searchLink>; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Brito+Monteiro+L%22">de Brito Monteiro L</searchLink>; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Muraro+SP%22">Muraro SP</searchLink>; Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Fabiano+de+Souza+G%22">Fabiano de Souza G</searchLink>; 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Autoimmune Research Laboratory, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil.; Experimental Medicine Research Cluster (EMRC), University of Campinas (UNICAMP), Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Velloso+LA%22">Velloso LA</searchLink>; Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas (UNICAMP), Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Proenca-Modena+JL%22">Proenca-Modena JL</searchLink>; Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil.; Experimental Medicine Research Cluster (EMRC), University of Campinas (UNICAMP), Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Mori+MA%22">Mori MA</searchLink>; Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, University of Campinas (UNICAMP), Campinas, Brazil.; Experimental Medicine Research Cluster (EMRC), University of Campinas (UNICAMP), Campinas, Brazil.; Laboratory of Aging Biology, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Loh+W%22">Loh W</searchLink>; Institute of Chemistry, University of Campinas (UNICAMP), Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Bhatt+DL%22">Bhatt DL</searchLink>; Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY, United States.<br /><searchLink fieldCode="AU" term="%22Yellon+DM%22">Yellon DM</searchLink>; The Hatter Cardiovascular Institute, University College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Davidson+SM%22">Davidson SM</searchLink>; The Hatter Cardiovascular Institute, University College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22De+Oliveira+PG%22">De Oliveira PG</searchLink>; Instituto de Ortopedia e Traumatologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, Brazil.; 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