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Machine-guided design of cell-type-targeting cis-regulatory elements.

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Title: Machine-guided design of cell-type-targeting cis-regulatory elements.
Authors: Gosai SJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA. sgosai@broadinstitute.org.; Harvard Graduate Program in Biological and Biomedical Science, Boston, MA, USA. sgosai@broadinstitute.org.; Department Of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA. sgosai@broadinstitute.org.; Howard Hughes Medical Institute, Chevy Chase, MD, USA. sgosai@broadinstitute.org., Castro RI; The Jackson Laboratory, Bar Harbor, ME, USA. rodrigo.castro@jax.org., Fuentes N; The Jackson Laboratory, Bar Harbor, ME, USA.; Harvard College, Harvard University, Cambridge, MA, USA., Butts JC; The Jackson Laboratory, Bar Harbor, ME, USA.; Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, ME, USA., Mouri K; The Jackson Laboratory, Bar Harbor, ME, USA., Alasoadura M; The Jackson Laboratory, Bar Harbor, ME, USA., Kales S; The Jackson Laboratory, Bar Harbor, ME, USA., Nguyen TTL; Department of Genetics, Yale School of Medicine, New Haven, CT, USA., Noche RR; Department of Comparative Medicine, Yale School of Medicine, New Haven, CT, USA.; Yale Zebrafish Research Core, Yale School of Medicine, New Haven, CT, USA., Rao AS; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA., Joy MT; The Jackson Laboratory, Bar Harbor, ME, USA., Sabeti PC; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department Of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA.; Department of Immunology and Infectious Diseases, Harvard T H Chan School of Public Health, Harvard University, Boston, MA, USA., Reilly SK; Department of Genetics, Yale School of Medicine, New Haven, CT, USA. steven.k.reilly@yale.edu.; Wu Tsai Institute, Yale University, New Haven, CT, USA. steven.k.reilly@yale.edu., Tewhey R; The Jackson Laboratory, Bar Harbor, ME, USA. ryan.tewhey@jax.org.; Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, ME, USA. ryan.tewhey@jax.org.; Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA, USA. ryan.tewhey@jax.org.
Source: Nature [Nature] 2024 Oct; Vol. 634 (8036), pp. 1211-1220. Date of Electronic Publication: 2024 Oct 23.
Publication Type: Journal Article; Validation Study; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Gosai+SJ%22">Gosai SJ</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA. sgosai@broadinstitute.org.; Harvard Graduate Program in Biological and Biomedical Science, Boston, MA, USA. sgosai@broadinstitute.org.; Department Of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA. sgosai@broadinstitute.org.; Howard Hughes Medical Institute, Chevy Chase, MD, USA. sgosai@broadinstitute.org.<br /><searchLink fieldCode="AU" term="%22Castro+RI%22">Castro RI</searchLink>; The Jackson Laboratory, Bar Harbor, ME, USA. rodrigo.castro@jax.org.<br /><searchLink fieldCode="AU" term="%22Fuentes+N%22">Fuentes N</searchLink>; The Jackson Laboratory, Bar Harbor, ME, USA.; Harvard College, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Butts+JC%22">Butts JC</searchLink>; The Jackson Laboratory, Bar Harbor, ME, USA.; Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, ME, USA.<br /><searchLink fieldCode="AU" term="%22Mouri+K%22">Mouri K</searchLink>; The Jackson Laboratory, Bar Harbor, ME, USA.<br /><searchLink fieldCode="AU" term="%22Alasoadura+M%22">Alasoadura M</searchLink>; The Jackson Laboratory, Bar Harbor, ME, USA.<br /><searchLink fieldCode="AU" term="%22Kales+S%22">Kales S</searchLink>; The Jackson Laboratory, Bar Harbor, ME, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+TTL%22">Nguyen TTL</searchLink>; Department of Genetics, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Noche+RR%22">Noche RR</searchLink>; Department of Comparative Medicine, Yale School of Medicine, New Haven, CT, USA.; Yale Zebrafish Research Core, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Rao+AS%22">Rao AS</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Joy+MT%22">Joy MT</searchLink>; The Jackson Laboratory, Bar Harbor, ME, USA.<br /><searchLink fieldCode="AU" term="%22Sabeti+PC%22">Sabeti PC</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department Of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA.; Department of Immunology and Infectious Diseases, Harvard T H Chan School of Public Health, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Reilly+SK%22">Reilly SK</searchLink>; Department of Genetics, Yale School of Medicine, New Haven, CT, USA. steven.k.reilly@yale.edu.; Wu Tsai Institute, Yale University, New Haven, CT, USA. steven.k.reilly@yale.edu.<br /><searchLink fieldCode="AU" term="%22Tewhey+R%22">Tewhey R</searchLink>; The Jackson Laboratory, Bar Harbor, ME, USA. ryan.tewhey@jax.org.; Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, ME, USA. ryan.tewhey@jax.org.; Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA, USA. ryan.tewhey@jax.org.
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