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Interferon-gamma driven elevation of CXCL9: a new sepsis endotype independently associated with mortality.

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Title: Interferon-gamma driven elevation of CXCL9: a new sepsis endotype independently associated with mortality.
Authors: Giamarellos-Bourboulis EJ; 4(th) Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece; Hellenic Institute for the Study of Sepsis, Athens, Greece. Electronic address: egiamarel@med.uoa.gr., Antonelli M; Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Rome, Italy; Dipartimento di Scienze dell'Emergenza, Anestesiologiche e della Rianimazione, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Bloos F; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Greece., Kotsamidi I; Intensive Care Unit, General Hospital 'Ippokrateion', Thessaloniki, Greece., Psarrakis C; 4(th) Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece., Dakou K; Hellenic Institute for the Study of Sepsis, Athens, Greece., Thomas-Rüddel D; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Greece., Montini L; Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Rome, Italy; Dipartimento di Scienze dell'Emergenza, Anestesiologiche e della Rianimazione, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Briegel J; Department of Anesthesiology, LMU Klinikum, LMU Munich, Munich, Greece., Damoraki G; 4(th) Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece., Koufargyris P; 4(th) Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece., Anisoglou S; Intensive Care Unit, Theageneio General Hospital, Thessaloniki, Greece., Antoniadou E; Intensive Care Unit, General Hospital 'G.Gennimatas', Thessaloniki, Greece., Vlachogianni G; Intensive Care Unit, General Hospital 'Aghios Dimitrios', Thessaloniki, Greece., Tsiantas C; Intensive Care Unit, General Hospital AHEPA, Thessaloniki, Greece., Masullo M; Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Rome, Italy; Dipartimento di Scienze dell'Emergenza, Anestesiologiche e della Rianimazione, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Ioakeimidou A; Intensive Care Unit, General Hospital Asklipeion, Voula, Greece., Kondili E; Department of Critical Care Medicine, University of Crete, Medical School, Herakleion, Greece., Ntaganou M; Multivalent Intensive Care Unit, General Hospital of Chest Diseases 'Sotiria', Athens, Greece., Gkeka E; Intensive Care Unit, General Hospital AHEPA, Thessaloniki, Greece., Papaioannou V; Department of Critical Care Medicine, Democritus University of Thrace Medical School, Alexandroupolis, Greece., Polyzogopoulou E; Department of Emergency Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece., Reininger AJ; Swedish Orphan Biovitrum, Basel, Switzerland., De Pascale G; Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Rome, Italy; Dipartimento di Scienze dell'Emergenza, Anestesiologiche e della Rianimazione, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Kiehntopf M; Institute of Clinical Chemistry and Laboratory Diagnostics and Integrated Biobank Jena, Jena University Hospital, Jena, Germany., Mouloudi E; Intensive Care Unit, General Hospital 'Ippokrateion', Thessaloniki, Greece., Bauer M; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Greece.
Source: EBioMedicine [EBioMedicine] 2024 Nov; Vol. 109, pp. 105414. Date of Electronic Publication: 2024 Oct 23.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101647039 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3964 (Electronic) Linking ISSN: 23523964 NLM ISO Abbreviation: EBioMedicine Subsets: MEDLINE
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  Data: Interferon-gamma driven elevation of CXCL9: a new sepsis endotype independently associated with mortality.
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  Data: <searchLink fieldCode="AU" term="%22Giamarellos-Bourboulis+EJ%22">Giamarellos-Bourboulis EJ</searchLink>; 4(th) Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece; Hellenic Institute for the Study of Sepsis, Athens, Greece. Electronic address: egiamarel@med.uoa.gr.<br /><searchLink fieldCode="AU" term="%22Antonelli+M%22">Antonelli M</searchLink>; Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Rome, Italy; Dipartimento di Scienze dell'Emergenza, Anestesiologiche e della Rianimazione, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Bloos+F%22">Bloos F</searchLink>; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Greece.<br /><searchLink fieldCode="AU" term="%22Kotsamidi+I%22">Kotsamidi I</searchLink>; Intensive Care Unit, General Hospital 'Ippokrateion', Thessaloniki, Greece.<br /><searchLink fieldCode="AU" term="%22Psarrakis+C%22">Psarrakis C</searchLink>; 4(th) Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Dakou+K%22">Dakou K</searchLink>; Hellenic Institute for the Study of Sepsis, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Thomas-Rüddel+D%22">Thomas-Rüddel D</searchLink>; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Greece.<br /><searchLink fieldCode="AU" term="%22Montini+L%22">Montini L</searchLink>; Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Rome, Italy; Dipartimento di Scienze dell'Emergenza, Anestesiologiche e della Rianimazione, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Briegel+J%22">Briegel J</searchLink>; Department of Anesthesiology, LMU Klinikum, LMU Munich, Munich, Greece.<br /><searchLink fieldCode="AU" term="%22Damoraki+G%22">Damoraki G</searchLink>; 4(th) Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Koufargyris+P%22">Koufargyris P</searchLink>; 4(th) Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Anisoglou+S%22">Anisoglou S</searchLink>; Intensive Care Unit, Theageneio General Hospital, Thessaloniki, Greece.<br /><searchLink fieldCode="AU" term="%22Antoniadou+E%22">Antoniadou E</searchLink>; Intensive Care Unit, General Hospital 'G.Gennimatas', Thessaloniki, Greece.<br /><searchLink fieldCode="AU" term="%22Vlachogianni+G%22">Vlachogianni G</searchLink>; Intensive Care Unit, General Hospital 'Aghios Dimitrios', Thessaloniki, Greece.<br /><searchLink fieldCode="AU" term="%22Tsiantas+C%22">Tsiantas C</searchLink>; Intensive Care Unit, General Hospital AHEPA, Thessaloniki, Greece.<br /><searchLink fieldCode="AU" term="%22Masullo+M%22">Masullo M</searchLink>; Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Rome, Italy; Dipartimento di Scienze dell'Emergenza, Anestesiologiche e della Rianimazione, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Ioakeimidou+A%22">Ioakeimidou A</searchLink>; Intensive Care Unit, General Hospital Asklipeion, Voula, Greece.<br /><searchLink fieldCode="AU" term="%22Kondili+E%22">Kondili E</searchLink>; Department of Critical Care Medicine, University of Crete, Medical School, Herakleion, Greece.<br /><searchLink fieldCode="AU" term="%22Ntaganou+M%22">Ntaganou M</searchLink>; Multivalent Intensive Care Unit, General Hospital of Chest Diseases 'Sotiria', Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Gkeka+E%22">Gkeka E</searchLink>; Intensive Care Unit, General Hospital AHEPA, Thessaloniki, Greece.<br /><searchLink fieldCode="AU" term="%22Papaioannou+V%22">Papaioannou V</searchLink>; Department of Critical Care Medicine, Democritus University of Thrace Medical School, Alexandroupolis, Greece.<br /><searchLink fieldCode="AU" term="%22Polyzogopoulou+E%22">Polyzogopoulou E</searchLink>; Department of Emergency Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Reininger+AJ%22">Reininger AJ</searchLink>; Swedish Orphan Biovitrum, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22De+Pascale+G%22">De Pascale G</searchLink>; Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Rome, Italy; Dipartimento di Scienze dell'Emergenza, Anestesiologiche e della Rianimazione, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Kiehntopf+M%22">Kiehntopf M</searchLink>; Institute of Clinical Chemistry and Laboratory Diagnostics and Integrated Biobank Jena, Jena University Hospital, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Mouloudi+E%22">Mouloudi E</searchLink>; Intensive Care Unit, General Hospital 'Ippokrateion', Thessaloniki, Greece.<br /><searchLink fieldCode="AU" term="%22Bauer+M%22">Bauer M</searchLink>; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Greece.
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